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Aliases for CHRDL2 Gene

Aliases for CHRDL2 Gene

  • Chordin Like 2 2 3 5
  • Breast Tumor Novel Factor 1 3 4
  • Chordin-Related Protein 2 3 4
  • BNF1 3 4
  • CHL2 3 4
  • Chordin-Like Protein 2 3
  • BNF-1 4

External Ids for CHRDL2 Gene

Previous GeneCards Identifiers for CHRDL2 Gene

  • GC11M074133
  • GC11M074085
  • GC11M074407
  • GC11M070703

Summaries for CHRDL2 Gene

Entrez Gene Summary for CHRDL2 Gene

  • This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

GeneCards Summary for CHRDL2 Gene

CHRDL2 (Chordin Like 2) is a Protein Coding gene. An important paralog of this gene is CHRDL1.

UniProtKB/Swiss-Prot for CHRDL2 Gene

  • May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.

Additional gene information for CHRDL2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRDL2 Gene

Genomics for CHRDL2 Gene

GeneHancer (GH) Regulatory Elements for CHRDL2 Gene

Promoters and enhancers for CHRDL2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J074731 Promoter 0.8 EPDnew 650.7 +0.1 101 0.1 SUZ12 ZBTB26 PRDM1 EZH2 CHRDL2 XRRA1 MIR4696
GH11J074732 Promoter 0.7 EPDnew 650.7 -0.1 -61 0.1 SUZ12 ZBTB26 CHRDL2 RPL36AP38
GH11J074671 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17 +58.2 58231 3.4 HDGF ATF1 ARNT SIN3A GATA2 ZNF143 FOS ATF7 RXRA ATF4 CHRDL2 C2CD3 RPS12P22 KCNE3 RN7SKP297 GC11P074653
GH11J074753 Enhancer 1.2 FANTOM5 Ensembl ENCODE 11.2 -23.5 -23544 2.8 HDGF JUN CEBPG POLR2A ZNF143 FOSL2 FOS IKZF2 RUNX3 CREM CHRDL2 XRRA1 RNF169 POLD3 ENSG00000278879
GH11J074611 Enhancer 0.8 Ensembl ENCODE 15.9 +119.6 119585 0.8 CTCF DACH1 MAFG BACH1 REST RAD21 ZNF592 ZNF316 SMC3 NFE2 CHRDL2 KCNE3 ENSG00000254928 POLD3 LOC105369386 GC11M074646
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHRDL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHRDL2 gene promoter:
  • FOXO3b
  • FOXO3a
  • FOXO3
  • Roaz
  • AhR
  • Egr-3
  • Pax-2
  • Pax-2a
  • Egr-4

Genomic Locations for CHRDL2 Gene

Genomic Locations for CHRDL2 Gene
34,958 bases
Minus strand
34,957 bases
Minus strand

Genomic View for CHRDL2 Gene

Genes around CHRDL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRDL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRDL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRDL2 Gene

Proteins for CHRDL2 Gene

  • Protein details for CHRDL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chordin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A5PKU9
    • Q6WN30
    • Q6WN31
    • Q6WN32
    • Q7Z5J3

    Protein attributes for CHRDL2 Gene

    429 amino acids
    Molecular mass:
    47495 Da
    Quaternary structure:
    • Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.

    Alternative splice isoforms for CHRDL2 Gene


neXtProt entry for CHRDL2 Gene

Post-translational modifications for CHRDL2 Gene

  • Phosphorylated by FAM20C in the extracellular medium.
  • Glycosylation at posLast=343343, Asn114, and Thr100
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CHRDL2 Gene

Domains & Families for CHRDL2 Gene

Gene Families for CHRDL2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CHRDL2 Gene


Suggested Antigen Peptide Sequences for CHRDL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHRDL2: view

No data available for UniProtKB/Swiss-Prot for CHRDL2 Gene

Function for CHRDL2 Gene

Molecular function for CHRDL2 Gene

UniProtKB/Swiss-Prot Function:
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in breast tumors but also in lung and colon tumors.

Phenotypes From GWAS Catalog for CHRDL2 Gene

Gene Ontology (GO) - Molecular Function for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with CHRDL2: view
genes like me logo Genes that share phenotypes with CHRDL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRDL2

miRNA for CHRDL2 Gene

miRTarBase miRNAs that target CHRDL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHRDL2 Gene

Localization for CHRDL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRDL2 Gene

Isoform 1: Secreted.
Isoform 2: Secreted.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRDL2 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytoskeleton 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space HDA 16502470
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CHRDL2: view

Pathways & Interactions for CHRDL2 Gene

SuperPathways for CHRDL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0051216 cartilage development IEA --
genes like me logo Genes that share ontologies with CHRDL2: view

No data available for Pathways by source and SIGNOR curated interactions for CHRDL2 Gene

Drugs & Compounds for CHRDL2 Gene

No Compound Related Data Available

Transcripts for CHRDL2 Gene

Unigene Clusters for CHRDL2 Gene

Chordin-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRDL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for CHRDL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRDL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHRDL2 Gene

mRNA differential expression in normal tissues according to GTEx for CHRDL2 Gene

This gene is overexpressed in Uterus (x10.0), Colon - Sigmoid (x6.4), Cervix - Ectocervix (x5.9), and Stomach (x4.9).

Protein differential expression in normal tissues from HIPED for CHRDL2 Gene

This gene is overexpressed in Milk (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHRDL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHRDL2 Gene:


SOURCE GeneReport for Unigene cluster for CHRDL2 Gene:


mRNA Expression by UniProt/SwissProt for CHRDL2 Gene:

Tissue specificity: Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.
genes like me logo Genes that share expression patterns with CHRDL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRDL2 Gene

Orthologs for CHRDL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRDL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHRDL2 34 33
  • 93.93 (n)
(Bos Taurus)
Mammalia CHRDL2 34 33
  • 88.5 (n)
(Canis familiaris)
Mammalia CHRDL2 34 33
  • 83.54 (n)
(Mus musculus)
Mammalia Chrdl2 16 34 33
  • 80 (n)
(Rattus norvegicus)
Mammalia Chrdl2 33
  • 79.67 (n)
(Monodelphis domestica)
Mammalia CHRDL2 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia CHRDL2 34
  • 54 (a)
(Gallus gallus)
Aves CHRDL2 34 33
  • 68.5 (n)
(Anolis carolinensis)
Reptilia CHRDL2 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733103 33
  • 72.99 (n)
(Danio rerio)
Actinopterygii chrdl2 34 33
  • 55.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta sog 34
  • 4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 2 (a)
Species where no ortholog for CHRDL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHRDL2 Gene

Gene Tree for CHRDL2 (if available)
Gene Tree for CHRDL2 (if available)
Evolutionary constrained regions (ECRs) for CHRDL2: view image

Paralogs for CHRDL2 Gene

Paralogs for CHRDL2 Gene

(4) SIMAP similar genes for CHRDL2 Gene using alignment to 5 proteins:

  • A8MQ10_HUMAN
  • Q6WN33_HUMAN
genes like me logo Genes that share paralogs with CHRDL2: view

Variants for CHRDL2 Gene

Sequence variations from dbSNP and Humsavar for CHRDL2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000055375 -- 74,724,805(-) T/G genic_upstream_transcript_variant, intron_variant
rs1000086981 -- 74,706,070(-) G/A intron_variant
rs1000120771 -- 74,725,177(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000193620 -- 74,715,520(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000338215 -- 74,712,131(-) A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CHRDL2 Gene

Variant ID Type Subtype PubMed ID
dgv209e214 CNV gain 21293372
esv2744778 CNV deletion 23290073
esv2759837 CNV gain 17122850
esv34979 CNV gain 17911159
esv3626846 CNV gain 21293372
nsv509431 CNV insertion 20534489
nsv825994 CNV gain 20364138

Variation tolerance for CHRDL2 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHRDL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRDL2 Gene

Disorders for CHRDL2 Gene

Additional Disease Information for CHRDL2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CHRDL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRDL2 Gene

Publications for CHRDL2 Gene

  1. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. (PMID: 14660436) Nakayama N … Zhang K (Development (Cambridge, England) 2004) 3 4 22 58
  2. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. (PMID: 15094188) Oren A … Rotman G (Gene 2004) 3 4 22 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  4. BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues. (PMID: 12853144) Wu I … Moses MA (Gene 2003) 2 3 4 58
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges LM … MrOS Research Group (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009) 3 44 58

Products for CHRDL2 Gene

Sources for CHRDL2 Gene

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