External Ids for CHRD Gene
Previous GeneCards Identifiers for CHRD Gene
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]
GeneCards Summary for CHRD Gene
CHRD (Chordin) is a Protein Coding gene. Diseases associated with CHRD include Cornelia De Lange Syndrome and Holoprosencephaly. Among its related pathways are TGF-beta signaling pathway (KEGG) and Signaling by BMP. Gene Ontology (GO) annotations related to this gene include heparin binding and syndecan binding. An important paralog of this gene is MUC5B.
UniProtKB/Swiss-Prot Summary for CHRD Gene
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).