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Aliases for CHRAC1 Gene

Aliases for CHRAC1 Gene

  • Chromatin Accessibility Complex 1 2 3 5
  • Chromatin Accessibility Complex 15 KDa Protein 3 4
  • DNA Polymerase Epsilon Subunit P15 3 4
  • Histone-Fold Protein CHRAC15 2 3
  • CHRAC-15 3 4
  • CHRAC-1 3 4
  • CHRAC15 3 4
  • Chromatin Accessibility Complex Protein 1 3
  • HuCHRAC15 4
  • CHARC15 3
  • CHARC1 3
  • YCL1 3

External Ids for CHRAC1 Gene

Previous GeneCards Identifiers for CHRAC1 Gene

  • GC08P141708
  • GC08P141205
  • GC08P141492
  • GC08P141590
  • GC08P141521
  • GC08P136832

Summaries for CHRAC1 Gene

Entrez Gene Summary for CHRAC1 Gene

  • CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

GeneCards Summary for CHRAC1 Gene

CHRAC1 (Chromatin Accessibility Complex 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for CHRAC1 Gene

  • Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

Additional gene information for CHRAC1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRAC1 Gene

Genomics for CHRAC1 Gene

GeneHancer (GH) Regulatory Elements for CHRAC1 Gene

Promoters and enhancers for CHRAC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I140509 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 577.3 +0.7 657 4.4 HDGF CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B CHRAC1 GC08M140501 GC08P140525
GH08I140506 Enhancer 1.2 Ensembl ENCODE dbSUPER 38.3 -3.2 -3246 2.8 PKNOX1 ATF1 BATF IRF4 ZNF121 ATF7 ETV6 IKZF2 RUNX3 CREM ENSG00000259891 CHRAC1 GC08M140501
GH08I140456 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 16.6 -52.5 -52518 4.8 FEZF1 YBX1 IRF4 ZNF143 ZNF263 SP3 NFYC MEF2D GLIS1 NBN TRAPPC9 CHRAC1 AGO2 ENSG00000259891 PIR60466
GH08I140633 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11 +124.4 124362 4.7 HDGF ARID4B SIN3A ZNF2 ZBTB7B ZNF766 ZNF207 ZNF143 DEK SP3 AGO2 ERICD CHRAC1 GC08P140597
GH08I140596 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +87.0 86992 4.5 HDGF ATF1 SIN3A FEZF1 IRF4 ATF7 RUNX3 JUNB ATF4 MYNN GC08P140597 AGO2 CHRAC1 TRAPPC9 ERICD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHRAC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHRAC1 gene promoter:

Genomic Locations for CHRAC1 Gene

Genomic Locations for CHRAC1 Gene
5,856 bases
Plus strand

Genomic View for CHRAC1 Gene

Genes around CHRAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRAC1 Gene

Proteins for CHRAC1 Gene

  • Protein details for CHRAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chromatin accessibility complex protein 1
    Protein Accession:

    Protein attributes for CHRAC1 Gene

    131 amino acids
    Molecular mass:
    14711 Da
    Quaternary structure:
    • Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

neXtProt entry for CHRAC1 Gene

Post-translational modifications for CHRAC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHRAC1 Gene

No data available for DME Specific Peptides for CHRAC1 Gene

Domains & Families for CHRAC1 Gene

Gene Families for CHRAC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CHRAC1 Gene

Suggested Antigen Peptide Sequences for CHRAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHRAC1: view

No data available for UniProtKB/Swiss-Prot for CHRAC1 Gene

Function for CHRAC1 Gene

Molecular function for CHRAC1 Gene

UniProtKB/Swiss-Prot Function:
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

Phenotypes From GWAS Catalog for CHRAC1 Gene

Gene Ontology (GO) - Molecular Function for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10880450
GO:0003887 DNA-directed DNA polymerase activity NAS 10880450
GO:0005515 protein binding IPI 21516116
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with CHRAC1: view
genes like me logo Genes that share phenotypes with CHRAC1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHRAC1 Gene

Localization for CHRAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRAC1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRAC1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0008622 epsilon DNA polymerase complex NAS 10880450
GO:0008623 CHRAC NAS 10880450
genes like me logo Genes that share ontologies with CHRAC1: view

Pathways & Interactions for CHRAC1 Gene

SuperPathways for CHRAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling NAS 10880450
GO:0071897 DNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with CHRAC1: view

No data available for Pathways by source and SIGNOR curated interactions for CHRAC1 Gene

Drugs & Compounds for CHRAC1 Gene

No Compound Related Data Available

Transcripts for CHRAC1 Gene

Unigene Clusters for CHRAC1 Gene

Chromatin accessibility complex 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRAC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for CHRAC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHRAC1 Gene

Protein differential expression in normal tissues from HIPED for CHRAC1 Gene

This gene is overexpressed in Pancreas (25.7) and Lung (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHRAC1 Gene

Protein tissue co-expression partners for CHRAC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHRAC1 Gene:


SOURCE GeneReport for Unigene cluster for CHRAC1 Gene:


mRNA Expression by UniProt/SwissProt for CHRAC1 Gene:

Tissue specificity: Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with CHRAC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRAC1 Gene

Orthologs for CHRAC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRAC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHRAC1 33 34
  • 92.56 (n)
(Bos Taurus)
Mammalia CHRAC1 33 34
  • 88.59 (n)
(Mus musculus)
Mammalia Chrac1 33 16 34
  • 87.23 (n)
(Rattus norvegicus)
Mammalia Chrac1 33
  • 87.23 (n)
(Canis familiaris)
Mammalia CHRAC1 34
  • 78 (a)
(Monodelphis domestica)
Mammalia CHRAC1 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia CHRAC1 34
  • 67 (a)
(Gallus gallus)
Aves CHRAC1 33 34
  • 79.04 (n)
(Anolis carolinensis)
Reptilia CHRAC1 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chrac1 33
  • 75.44 (n)
Str.1765 33
(Danio rerio)
Actinopterygii chrac1 33 34
  • 60.94 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4122 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007481 33
  • 54.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta Chrac-16 34
  • 29 (a)
Species where no ortholog for CHRAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHRAC1 Gene

Gene Tree for CHRAC1 (if available)
Gene Tree for CHRAC1 (if available)

Paralogs for CHRAC1 Gene

(2) SIMAP similar genes for CHRAC1 Gene using alignment to 4 proteins: Pseudogenes for CHRAC1 Gene

genes like me logo Genes that share paralogs with CHRAC1: view

No data available for Paralogs for CHRAC1 Gene

Variants for CHRAC1 Gene

Sequence variations from dbSNP and Humsavar for CHRAC1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000079419 -- 140,512,063(+) C/G/T intron_variant
rs1000404144 -- 140,510,526(+) C/T upstream_transcript_variant
rs1000414246 -- 140,510,264(+) G/A upstream_transcript_variant
rs1000536307 -- 140,511,879(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001281777 -- 140,515,946(+) A/G 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CHRAC1 Gene

Variant ID Type Subtype PubMed ID
dgv12367n54 CNV gain 21841781
esv2737756 CNV deletion 23290073
esv3619033 CNV gain 21293372
nsv1016282 CNV gain 25217958
nsv1126125 CNV deletion 24896259
nsv465951 CNV loss 19166990
nsv509283 CNV insertion 20534489
nsv612566 CNV loss 21841781

Variation tolerance for CHRAC1 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHRAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRAC1 Gene

Disorders for CHRAC1 Gene

Additional Disease Information for CHRAC1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CHRAC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRAC1 Gene

Publications for CHRAC1 Gene

  1. Cloning and characterization of the histone-fold proteins YBL1 and YCL1. (PMID: 11000277) Bolognese F … Mantovani R (Nucleic acids research 2000) 2 3 22 58
  2. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. (PMID: 10880450) Poot RA … Varga-Weisz PD (The EMBO journal 2000) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. (PMID: 14759371) Kukimoto I … Varga-Weisz PD (Molecular cell 2004) 3 22 58

Products for CHRAC1 Gene

Sources for CHRAC1 Gene

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