Aliases for CHRAC1 Gene
External Ids for CHRAC1 Gene
Previous GeneCards Identifiers for CHRAC1 Gene
CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
GeneCards Summary for CHRAC1 Gene
CHRAC1 (Chromatin Accessibility Complex Subunit 1) is a Protein Coding gene. Diseases associated with CHRAC1 include Valproate Embryopathy and Autosomal Recessive Non-Syndromic Intellectual Disability. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.
UniProtKB/Swiss-Prot Summary for CHRAC1 Gene
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.