CHRAC1 Gene (Protein Coding)

Chromatin Accessibility Complex Subunit 1

GC08P140511
GIFtS:
36
CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004] See more...

Aliases for CHRAC1 Gene

Aliases for CHRAC1 Gene

  • Chromatin Accessibility Complex Subunit 1 2 3 5
  • CHRAC15 2 3 4
  • Chromatin Accessibility Complex 15 KDa Protein 3 4
  • Chromatin Accessibility Complex Protein 1 3 4
  • DNA Polymerase Epsilon Subunit P15 3 4
  • Histone-Fold Protein CHRAC15 2 3
  • CHRAC-15 3 4
  • CHRAC-1 3 4
  • YCL1 2 3
  • Chromatin Accessibility Complex 1 3
  • HuCHRAC15 4
  • CHARC15 3
  • CHARC1 3
  • CHRAC1 5

External Ids for CHRAC1 Gene

Previous GeneCards Identifiers for CHRAC1 Gene

  • GC08P140484
  • GC08P141708
  • GC08P141205
  • GC08P141492
  • GC08P141590
  • GC08P141521
  • GC08P136832

Summaries for CHRAC1 Gene

Entrez Gene Summary for CHRAC1 Gene

  • CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

GeneCards Summary for CHRAC1 Gene

CHRAC1 (Chromatin Accessibility Complex Subunit 1) is a Protein Coding gene. Diseases associated with CHRAC1 include Valproate Embryopathy and Autosomal Recessive Non-Syndromic Intellectual Disability. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot Summary for CHRAC1 Gene

  • Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

Additional gene information for CHRAC1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHRAC1 Gene

Genomics for CHRAC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CHRAC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHRAC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHRAC1

Top Transcription factor binding sites by QIAGEN in the CHRAC1 gene promoter:
  • C/EBPalpha
  • Evi-1
  • GCNF
  • GCNF-1
  • GCNF-2

Genomic Locations for CHRAC1 Gene

Genomic Locations for CHRAC1 Gene
chr8:140,511,311-140,517,154
(GRCh38/hg38)
Size:
5,844 bases
Orientation:
Plus strand
chr8:141,521,397-141,527,252
(GRCh37/hg19)
Size:
5,856 bases
Orientation:
Plus strand

Genomic View for CHRAC1 Gene

Genes around CHRAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRAC1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHRAC1 Gene

Proteins for CHRAC1 Gene

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  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHRAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRG0-CHRC1_HUMAN
    Recommended name:
    Chromatin accessibility complex protein 1
    Protein Accession:
    Q9NRG0

    Protein attributes for CHRAC1 Gene

    Size:
    131 amino acids
    Molecular mass:
    14711 Da
    Quaternary structure:
    • Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

neXtProt entry for CHRAC1 Gene

Protein Expression for CHRAC1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CHRAC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHRAC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHRAC1 Gene

Domains & Families for CHRAC1 Gene

Gene Families for CHRAC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CHRAC1 Gene

InterPro:
Blocks:
  • Transcription factor CBF/NF-Y/archaeal histone
ProtoNet:

Suggested Antigen Peptide Sequences for CHRAC1 Gene

GenScript: Design optimal peptide antigens:
  • DNA polymerase epsilon subunit p15 (CHRC1_HUMAN)
genes like me logo Genes that share domains with CHRAC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CHRAC1 Gene

Function for CHRAC1 Gene

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  1. Animal Model
  2. CRISPR
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Molecular function for CHRAC1 Gene

UniProtKB/Swiss-Prot Function:
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

Phenotypes From GWAS Catalog for CHRAC1 Gene

Gene Ontology (GO) - Molecular Function for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10880450
GO:0003887 DNA-directed DNA polymerase activity NAS 10880450
GO:0005515 protein binding IPI 21516116
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with CHRAC1: view
genes like me logo Genes that share phenotypes with CHRAC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHRAC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHRAC1 Gene

Localization for CHRAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRAC1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRAC1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0008622 epsilon DNA polymerase complex NAS 10880450
GO:0008623 CHRAC NAS 10880450
genes like me logo Genes that share ontologies with CHRAC1: view

Pathways & Interactions for CHRAC1 Gene

PathCards logo

SuperPathways for CHRAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling NAS 10880450
GO:0071897 DNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with CHRAC1: view

No data available for Pathways by source and SIGNOR curated interactions for CHRAC1 Gene

Drugs & Compounds for CHRAC1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CHRAC1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CHRAC1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHRAC1

Alternative Splicing Database (ASD) splice patterns (SP) for CHRAC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for CHRAC1 Gene

GeneLoc Exon Structure for
CHRAC1

Expression for CHRAC1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHRAC1 Gene

mRNA expression in normal human tissues for CHRAC1 Gene
mRNA expression by GTEx for CHRAC1 Gene

Protein differential expression in normal tissues from HIPED for CHRAC1 Gene

This gene is overexpressed in Pancreas (25.7) and Lung (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHRAC1 Gene



Protein tissue co-expression partners for CHRAC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHRAC1

SOURCE GeneReport for Unigene cluster for CHRAC1 Gene:

Hs.279704

mRNA Expression by UniProt/SwissProt for CHRAC1 Gene:

Q9NRG0-CHRC1_HUMAN
Tissue specificity: Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with CHRAC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRAC1 Gene

Orthologs for CHRAC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRAC1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia CHRAC1 30 31
  • 92.56 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia CHRAC1 30 31
  • 88.59 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Chrac1 30 17 31
  • 87.23 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Chrac1 30
  • 87.23 (n)
Dog
(Canis familiaris)
 Mammalia CHRAC1 31
  • 78 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia CHRAC1 31
  • 75 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia CHRAC1 31
  • 67 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves CHRAC1 30 31
  • 79.04 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia CHRAC1 31
  • 64 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia chrac1 30
  • 75.44 (n)
Str.1765 30
Zebrafish
(Danio rerio)
 Actinopterygii chrac1 30 31
  • 60.94 (n)
 OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.4122 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007481 30
  • 54.68 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Chrac-16 31
  • 29 (a)
 OneToOne
Species where no ortholog for CHRAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CHRAC1 Gene

ENSEMBL:
Gene Tree for CHRAC1 (if available)
TreeFam:
Gene Tree for CHRAC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHRAC1: view image

Paralogs for CHRAC1 Gene

(2) SIMAP similar genes for CHRAC1 Gene using alignment to 4 proteins:

  • CHRC1_HUMAN
  • E5RGS9_HUMAN
  • H0YBP8_HUMAN
  • H0YBX4_HUMAN

Pseudogenes.org Pseudogenes for CHRAC1 Gene

genes like me logo Genes that share paralogs with CHRAC1: view

No data available for Paralogs for CHRAC1 Gene

Variants for CHRAC1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHRAC1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs2231522 - p.Cys55Tyr
rs2231524 - p.His126Arg

Additional dbSNP identifiers (rs#s) for CHRAC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CHRAC1 Gene

Variant ID Type Subtype PubMed ID
dgv12367n54 CNV gain 21841781
esv2737756 CNV deletion 23290073
esv3619033 CNV gain 21293372
nsv1016282 CNV gain 25217958
nsv1126125 CNV deletion 24896259
nsv465951 CNV loss 19166990
nsv509283 CNV insertion 20534489
nsv612566 CNV loss 21841781

Variation tolerance for CHRAC1 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHRAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHRAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRAC1 Gene

Disorders for CHRAC1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CHRAC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
valproate embryopathy
  • valproate embryopathy, susceptibility to
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for CHRAC1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CHRAC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHRAC1 Gene

Publications for CHRAC1 Gene

  1. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. (PMID: 10880450) Poot RA … Varga-Weisz PD (The EMBO journal 2000) 2 3 4
  2. Cloning and characterization of the histone-fold proteins YBL1 and YCL1. (PMID: 11000277) Bolognese F … Mantovani R (Nucleic acids research 2000) 2 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. (PMID: 14759371) Kukimoto I … Varga-Weisz PD (Molecular cell 2004) 3 23

ExternalLinks

View latest publications for CHRAC1 gene in Mastermind

Products for CHRAC1 Gene

  • Signalway Proteins for CHRAC1

Sources for CHRAC1 Gene