Aliases for CHRAC1 Gene
Aliases for CHRAC1 Gene
External Ids for CHRAC1 Gene
- HGNC: 13544
- Entrez Gene: 54108
- Ensembl: ENSG00000104472
- OMIM: 607268
- UniProtKB: Q9NRG0
Previous GeneCards Identifiers for CHRAC1 Gene
- GC08P141708
- GC08P141205
- GC08P141492
- GC08P141590
- GC08P141521
- GC08P136832
Summaries for CHRAC1 Gene
-
CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]
GeneCards Summary for CHRAC1 Gene
CHRAC1 (Chromatin Accessibility Complex 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.
UniProtKB/Swiss-Prot for CHRAC1 Gene
-
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.
Additional gene information for CHRAC1 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRAC1 Gene
Genomics for CHRAC1 Gene
GeneHancer (GH) Regulatory Elements for CHRAC1 Gene
Promoters and enhancers for CHRAC1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CHRAC1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CHRAC1 gene promoter:
Regulatory Element Products
Genomic Locations for CHRAC1 Gene
Genomic Locations for CHRAC1 Gene
- chr8:140,511,298-140,517,153
- (GRCh38/hg38)
- Size:
- 5,856 bases
- Orientation:
- Plus strand
- chr8:141,521,397-141,527,252
- (GRCh37/hg19)
Genomic View for CHRAC1 Gene
Genes around CHRAC1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.3 by Ensembl
- 8q24.3 by Entrez Gene
- 8q24.3 by HGNC
CHRAC1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHRAC1 Gene
Proteins for CHRAC1 Gene
-
Protein details for CHRAC1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NRG0-CHRC1_HUMAN
- Recommended name:
- Chromatin accessibility complex protein 1
- Protein Accession:
- Q9NRG0
Protein attributes for CHRAC1 Gene
- Size:
- 131 amino acids
- Molecular mass:
- 14711 Da
- Quaternary structure:
-
- Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.
Protein Expression for CHRAC1 Gene
Post-translational modifications for CHRAC1 Gene
Other Protein References for CHRAC1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CHRAC1
-
Abcam antibodies for CHRAC1
- Invitrogen Antibodies for CHRAC1
- Search GeneTex for Antibodies for CHRAC1
Protein Products
-
OriGene Purified Proteins for CHRAC1
- Search Origene for MassSpec and Protein Over-expression Lysates for CHRAC1
- Origene Custom Protein Services for CHRAC1
- ProSpec Recombinant Proteins for CHRAC1
- antibodies-online: Search results for 6 available CHRAC1 Proteins ranked by validation data
- Compare Top CHRAC1 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CHRAC1
-
Abcam proteins for CHRAC1
Assay Products
- antibodies-online: Search results for 2 available CHRAC1 Elisa Kits ranked by validation data
- Compare Top CHRAC1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CHRAC1 Gene
Domains & Families for CHRAC1 Gene
Gene Families for CHRAC1 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CHRAC1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CHRAC1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CHRAC1 Gene
Function for CHRAC1 Gene
Molecular function for CHRAC1 Gene
- UniProtKB/Swiss-Prot Function:
- Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.
Phenotypes From GWAS Catalog for CHRAC1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS | 10880450 |
| GO:0003887 | DNA-directed DNA polymerase activity | NAS | 10880450 |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016779 | nucleotidyltransferase activity | IEA | -- |
Phenotypes for CHRAC1 Gene
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRAC1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRAC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRAC1 gene
- Search ViGene Biosciences for CHRAC1
CRISPR Products
-
OriGene CRISPR knockouts for CHRAC1
- genomics-online: gRNA clones - Search results for 108 available CHRAC1 gene related products
- Overview of 108 available CHRAC1 gene related products
- Applied Biological Materials CRISPR for CHRAC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRAC1
- GenScript: Design CRISPR guide RNA sequences for CHRAC1
miRNA for CHRAC1 Gene
- miRTarBase miRNAs that target CHRAC1
miRNA Products
- Search ViGene Biosciences for CHRAC1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CHRAC1
- Browse OriGene Inhibitory RNA Products For CHRAC1
- genomics-online: shRNA clones - Search results for 108 available CHRAC1 gene related products
- Overview of 108 available CHRAC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRAC1 gene
Clone Products
- Sino Biological Human cDNA Clone for CHRAC1
- VectorBuilder custom plasmid, inducible vectors for CHRAC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRAC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CHRAC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CHRAC1
-
ViGene Biosciences adenoviral particle packaged cDNA for CHRAC1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CHRAC1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRAC1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHRAC1 Gene
Localization for CHRAC1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHRAC1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0008622 | epsilon DNA polymerase complex | NAS | 10880450 |
| GO:0008623 | CHRAC | NAS | 10880450 |
Pathways & Interactions for CHRAC1 Gene
No Data Available
Interacting Proteins for CHRAC1 Gene
Selected Interacting proteins:
Q9NRG0-CHRC1_HUMAN
ENSP00000220913
for CHRAC1 Gene via
IID
STRING
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006338 | chromatin remodeling | NAS | 10880450 |
| GO:0071897 | DNA biosynthetic process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CHRAC1 Gene
Transcripts for CHRAC1 Gene
mRNA/cDNA for CHRAC1 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (121) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CHRAC1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHRAC1
- genomics-online: gRNA clones - Search results for 108 available CHRAC1 gene related products
- Overview of 108 available CHRAC1 gene related products
- Applied Biological Materials CRISPR for CHRAC1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHRAC1
- GenScript: Design CRISPR guide RNA sequences for CHRAC1
miRNA Products
- Search ViGene Biosciences for CHRAC1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for CHRAC1
- Browse OriGene Inhibitory RNA Products For CHRAC1
- genomics-online: shRNA clones - Search results for 108 available CHRAC1 gene related products
- Overview of 108 available CHRAC1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CHRAC1 gene
Clone Products
- Sino Biological Human cDNA Clone for CHRAC1
- VectorBuilder custom plasmid, inducible vectors for CHRAC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRAC1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CHRAC1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: | - |
Expression for CHRAC1 Gene
This gene is overexpressed in Pancreas (25.7) and Lung (13.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHRAC1 Gene
NURSA nuclear receptor signaling pathways regulating expression of CHRAC1 Gene:
CHRAC1SOURCE GeneReport for Unigene cluster for CHRAC1 Gene:
Hs.279704mRNA Expression by UniProt/SwissProt for CHRAC1 Gene:
Q9NRG0-CHRC1_HUMAN
Tissue specificity:
Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Primer Products
-
OriGene qPCR primer pairs for CHRAC1
-
OriGene qPCR primer pairs and template standards for CHRAC1
- genomics-online: primer clones - Search results for 108 available CHRAC1 gene related products
- Overview of 108 available CHRAC1 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRAC1 Gene
Orthologs for CHRAC1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHRAC1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CHRAC1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Chrac1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chrac1 33 |
|
||
| dog (Canis familiaris) |
Mammalia | CHRAC1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CHRAC1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHRAC1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHRAC1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CHRAC1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chrac1 33 |
|
||
| Str.1765 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | chrac1 33 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.4122 33 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007481 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Chrac-16 34 |
|
OneToOne |
- Species where no ortholog for CHRAC1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CHRAC1 Gene
(2) SIMAP similar genes for CHRAC1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for CHRAC1 Gene
No data available for Paralogs for CHRAC1 Gene
Variants for CHRAC1 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000079419 | -- | 140,512,063(+) | C/G/T | intron_variant | |
| rs1000404144 | -- | 140,510,526(+) | C/T | upstream_transcript_variant | |
| rs1000414246 | -- | 140,510,264(+) | G/A | upstream_transcript_variant | |
| rs1000536307 | -- | 140,511,879(+) | C/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1001281777 | -- | 140,515,946(+) | A/G | 3_prime_UTR_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv12367n54 | CNV | gain | 21841781 |
| esv2737756 | CNV | deletion | 23290073 |
| esv3619033 | CNV | gain | 21293372 |
| nsv1016282 | CNV | gain | 25217958 |
| nsv1126125 | CNV | deletion | 24896259 |
| nsv465951 | CNV | loss | 19166990 |
| nsv509283 | CNV | insertion | 20534489 |
| nsv612566 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.45;
43.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHRAC1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CHRAC1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRAC1 Gene
Disorders for CHRAC1 Gene
Additional Disease Information for CHRAC1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CHRAC1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRAC1 Gene
Publications for CHRAC1 Gene
- Cloning and characterization of the histone-fold proteins YBL1 and YCL1. (PMID: 11000277) Bolognese F … Mantovani R (Nucleic acids research 2000) 2 3 22 58
- HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. (PMID: 10880450) Poot RA … Varga-Weisz PD (The EMBO journal 2000) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. (PMID: 14759371) Kukimoto I … Varga-Weisz PD (Molecular cell 2004) 3 22 58
Products for CHRAC1 Gene
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHRAC1
- VectorBuilder custom plasmid, inducible vectors for CHRAC1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CHRAC1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 43 available CHRAC1 Antibodies ranked by validation data
- Compare Top CHRAC1 Antibodies
- antibodies-online: Search results for 2 available CHRAC1 Elisa Kits ranked by validation data
- Compare Top CHRAC1 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 6 available CHRAC1 Proteins ranked by validation data
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- Quality Products:
- Search GeneTex for Antibodies for CHRAC1
- Search GeneTex for Proteins for CHRAC1
- ViGene Biosciences adenoviral particle packaged cDNA for CHRAC1 gene
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- Search ViGene Biosciences for CHRAC1
- Horizon Cell Lines for CHRAC1
- genomics-online: cdna clones - Search results for 108 available CHRAC1 gene related products
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- Overview of 108 available CHRAC1 gene related products
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- Overview of 108 available CHRAC1 gene related products
- genomics-online: shRNA clones - Search results for 108 available CHRAC1 gene related products
- Overview of 108 available CHRAC1 gene related products
Sources for CHRAC1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
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