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Aliases for CHP2 Gene

Aliases for CHP2 Gene

  • Calcineurin Like EF-Hand Protein 2 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 520 3 4
  • Hepatocellular Carcinoma Antigen Gene 520 3
  • Calcineurin B Homologous Protein 2 3
  • HCA520 4

External Ids for CHP2 Gene

Previous GeneCards Identifiers for CHP2 Gene

  • GC16P023674
  • GC16P023765
  • GC16P021855
  • GC16P023766
  • GC16P023782
  • GC16P023800

Summaries for CHP2 Gene

Entrez Gene Summary for CHP2 Gene

  • This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]

GeneCards Summary for CHP2 Gene

CHP2 (Calcineurin Like EF-Hand Protein 2) is a Protein Coding gene. Diseases associated with CHP2 include Hepatocellular Carcinoma. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for CHP2 Gene

  • Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

Additional gene information for CHP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHP2 Gene

Genomics for CHP2 Gene

GeneHancer (GH) Regulatory Elements for CHP2 Gene

Promoters and enhancers for CHP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J023754 Promoter/Enhancer 1.4 EPDnew ENCODE 650.7 +0.6 571 2.1 HDAC1 HDGF ATF1 RB1 NFIB KLF17 ZBTB40 ZNF335 GLIS2 KLF7 ENSG00000279756 CHP2 PRKCB
GH16J023803 Enhancer 1.1 Ensembl ENCODE 20.2 +49.2 49246 0.9 HDGF PKNOX1 ARNT ZNF2 ZNF280A TCF12 E2F8 ARID2 ZNF143 ATF7 PRKCB CHP2 ENSG00000261723 GC16M023816 ENSG00000279756
GH16J023676 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.3 -76.0 -76017 3.8 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B PLK1 PIR39200 DCTN5 ENSG00000260751 PALB2 ERN2 ENSG00000261723 NDUFAB1 RBBP6 SCNN1B
GH16J023825 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +72.2 72213 1.9 IRF4 RUNX3 RXRA JUNB NCOA1 ZNF592 MEF2D SMARCA4 NBN NR2C1 GC16M023816 PRKCB CHP2 GGA2
GH16J023727 Enhancer 1.2 Ensembl ENCODE 12.3 -26.5 -26523 0.9 ATF1 ARNT ARID4B ETS1 TCF12 ZNF766 ZNF143 ZFP91 FOS ATF7 RBBP6 ENSG00000261723 PALB2 ENSG00000260751 CHP2 GGA2 DCTN5 SCNN1B ERN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHP2 gene promoter:

Genomic Locations for CHP2 Gene

Genomic Locations for CHP2 Gene
chr16:23,754,627-23,758,951
(GRCh38/hg38)
Size:
4,325 bases
Orientation:
Plus strand
chr16:23,765,948-23,770,272
(GRCh37/hg19)

Genomic View for CHP2 Gene

Genes around CHP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHP2 Gene

Proteins for CHP2 Gene

  • Protein details for CHP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43745-CHP2_HUMAN
    Recommended name:
    Calcineurin B homologous protein 2
    Protein Accession:
    O43745
    Secondary Accessions:
    • A8K2I8

    Protein attributes for CHP2 Gene

    Size:
    196 amino acids
    Molecular mass:
    22452 Da
    Quaternary structure:
    • Interacts with PPP3CA. Interacts with SLC9A1/NHE1; the interaction occurs in a calcium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for CHP2 Gene

neXtProt entry for CHP2 Gene

Post-translational modifications for CHP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHP2 Gene

Domains & Families for CHP2 Gene

Gene Families for CHP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for CHP2 Gene

Suggested Antigen Peptide Sequences for CHP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43745

UniProtKB/Swiss-Prot:

CHP2_HUMAN :
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
Family:
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
genes like me logo Genes that share domains with CHP2: view

Function for CHP2 Gene

Molecular function for CHP2 Gene

UniProtKB/Swiss-Prot Function:
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

Phenotypes From GWAS Catalog for CHP2 Gene

Gene Ontology (GO) - Molecular Function for CHP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 21392185
GO:0005515 protein binding IPI 21392185
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CHP2: view
genes like me logo Genes that share phenotypes with CHP2: view

Animal Models for CHP2 Gene

MGI Knock Outs for CHP2:
  • Chp2 Chp2<tm1b(KOMP)Mbp>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHP2 Gene

Localization for CHP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHP2 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHP2 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for CHP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21392185
GO:0005737 cytoplasm IDA,IEA 21392185
GO:0005886 plasma membrane IDA,IEA 21392185
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CHP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHP2 Gene

Pathways & Interactions for CHP2 Gene

genes like me logo Genes that share pathways with CHP2: view

Pathways by source for CHP2 Gene

1 BioSystems pathway for CHP2 Gene

Gene Ontology (GO) - Biological Process for CHP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 18815128
GO:0010922 positive regulation of phosphatase activity IDA 18815128
GO:0015031 protein transport IEA --
GO:0042307 positive regulation of protein import into nucleus IDA 18815128
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 18815128
genes like me logo Genes that share ontologies with CHP2: view

No data available for SIGNOR curated interactions for CHP2 Gene

Drugs & Compounds for CHP2 Gene

No Compound Related Data Available

Transcripts for CHP2 Gene

mRNA/cDNA for CHP2 Gene

(37) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHP2 Gene

Calcineurin-like EF-hand protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHP2 Gene

No ASD Table

Relevant External Links for CHP2 Gene

GeneLoc Exon Structure for
CHP2
ECgene alternative splicing isoforms for
CHP2

Expression for CHP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHP2 Gene

This gene is overexpressed in Colon - Transverse (x15.2), Skin - Not Sun Exposed (Suprapubic) (x11.3), Skin - Sun Exposed (Lower leg) (x10.1), and Small Intestine - Terminal Ileum (x9.1).

Protein differential expression in normal tissues from HIPED for CHP2 Gene

This gene is overexpressed in Monocytes (34.2), Skin (9.7), Colon (7.4), and Rectum (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CHP2 Gene:

CHP2

SOURCE GeneReport for Unigene cluster for CHP2 Gene:

Hs.178589

mRNA Expression by UniProt/SwissProt for CHP2 Gene:

O43745-CHP2_HUMAN
Tissue specificity: Expressed in malignantly transformed cells but not detected in normal tissues.

Evidence on tissue expression from TISSUES for CHP2 Gene

  • Intestine(4.3)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CHP2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHP2 Gene

Orthologs for CHP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHP2 34 33
  • 99.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CHP2 34
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHP2 34 33
  • 85.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Chp2 16 34 33
  • 83.84 (n)
rat
(Rattus norvegicus)
Mammalia Chp2 33
  • 83.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHP2 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHP2 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii chp2 34 33
  • 64.95 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7594 33
fruit fly
(Drosophila melanogaster)
Insecta elm 34
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pbo-1 34 33
  • 53.62 (n)
ManyToMany
ZK856.8 34
  • 46 (a)
ManyToMany
F59D6.7 34
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 34
  • 38 (a)
OneToMany
Species where no ortholog for CHP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHP2 Gene

ENSEMBL:
Gene Tree for CHP2 (if available)
TreeFam:
Gene Tree for CHP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHP2: view image

Paralogs for CHP2 Gene

Paralogs for CHP2 Gene

(5) SIMAP similar genes for CHP2 Gene using alignment to 1 proteins:

  • CHP2_HUMAN
genes like me logo Genes that share paralogs with CHP2: view

Variants for CHP2 Gene

Sequence variations from dbSNP and Humsavar for CHP2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000062972 -- 23,753,960(+) C/T upstream_transcript_variant
rs1000073115 -- 23,753,793(+) C/T upstream_transcript_variant
rs1000218504 -- 23,753,938(+) G/A upstream_transcript_variant
rs1000275916 -- 23,758,710(+) T/A 3_prime_UTR_variant
rs1000322693 -- 23,759,308(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CHP2 Gene

Variant ID Type Subtype PubMed ID
nsv1064223 CNV loss 25217958
nsv510681 CNV deletion 20534489

Variation tolerance for CHP2 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.66; 56.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHP2 Gene

Disorders for CHP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search CHP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHP2

genes like me logo Genes that share disorders with CHP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHP2 Gene

Publications for CHP2 Gene

  1. Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. (PMID: 12226101) Pang T … Shigekawa M (The Journal of biological chemistry 2002) 2 3 4 22 58
  2. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PMID: 21507922) Ramsuran V … Ndung'u T (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2011) 3 44 58
  3. Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells. (PMID: 21392185) Li QH … Pang TX (Genes to cells : devoted to molecular & cellular mechanisms 2011) 3 4 58
  4. CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. (PMID: 18815128) Li GD … Zhang Y (The Journal of biological chemistry 2008) 3 4 58
  5. Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer. (PMID: 17708351) Jin Q … Yang Q (In vivo (Athens, Greece) 2007) 3 22 58

Products for CHP2 Gene

Sources for CHP2 Gene

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