This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expre... See more...

Aliases for CHN2 Gene

Aliases for CHN2 Gene

  • Chimerin 2 2 3 5
  • ARHGAP3 2 3 4
  • Chimerin (Chimaerin) 2 2 3
  • Beta-Chimaerin 3 4
  • Beta-Chimerin 3 4
  • BCH 3 4
  • Rho-GTPase-Activating Protein 3 3
  • Rho GTPase-Activating Protein 3 4
  • Chimerin, Testis-Specific 3
  • Chimerin, Beta-2 3
  • Beta3-Chimaerin 3
  • Beta Chimerin 2
  • Chimaerin 2 2
  • RHOGAP3 3
  • RhoGAP3 2
  • CHN2-3 3
  • CHN2 5

External Ids for CHN2 Gene

Previous GeneCards Identifiers for CHN2 Gene

  • GC07P028876
  • GC07P028976
  • GC07P029007
  • GC07P029200
  • GC07P029115

Summaries for CHN2 Gene

Entrez Gene Summary for CHN2 Gene

  • This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for CHN2 Gene

CHN2 (Chimerin 2) is a Protein Coding gene. Diseases associated with CHN2 include Hepatosplenic T-Cell Lymphoma and Duodenum Adenocarcinoma. Among its related pathways are Neuroscience and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is ENSG00000285162.

UniProtKB/Swiss-Prot Summary for CHN2 Gene

  • GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.

Gene Wiki entry for CHN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHN2 Gene

Genomics for CHN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CHN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHN2

Top Transcription factor binding sites by QIAGEN in the CHN2 gene promoter:
  • AREB6
  • FOXI1
  • GR
  • GR-alpha
  • GR-beta
  • HFH-3
  • Meis-1
  • Meis-1a
  • RelA
  • TGIF

Genomic Locations for CHN2 Gene

Genomic Locations for CHN2 Gene
chr7:29,146,547-29,514,335
(GRCh38/hg38)
Size:
367,789 bases
Orientation:
Plus strand
chr7:29,161,890-29,553,944
(GRCh37/hg19)
Size:
392,055 bases
Orientation:
Plus strand

Genomic View for CHN2 Gene

Genes around CHN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHN2 Gene

Proteins for CHN2 Gene

  • Protein details for CHN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52757-CHIO_HUMAN
    Recommended name:
    Beta-chimaerin
    Protein Accession:
    P52757
    Secondary Accessions:
    • A4D1A2
    • B3VCF1
    • B3VCF2
    • B3VCF3
    • B3VCF7
    • B3VCG1
    • C9J7B0
    • E9PGE0
    • F8QPL9
    • Q2M203
    • Q75MM2

    Protein attributes for CHN2 Gene

    Size:
    468 amino acids
    Molecular mass:
    53924 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CHN2 Gene

    Alternative splice isoforms for CHN2 Gene

neXtProt entry for CHN2 Gene

Post-translational modifications for CHN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CHN2 Gene

Domains & Families for CHN2 Gene

Gene Families for CHN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CHN2 Gene

InterPro:
Blocks:
  • SH2 domain signature
  • RhoGAP domain
  • Protein kinase C, phorbol ester/diacylglycerol binding
ProtoNet:

Suggested Antigen Peptide Sequences for CHN2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93489, Homo sapiens chimerin (chimaerin) 2 (CHN2), mRNA (A4D1A2_HUMAN)
  • Beta chimaerin isoform B1-CHNdel ex7p-8,11-12 (B3VCE9_HUMAN)
  • Beta chimaerin isoform B1-CHNdel ex7p-9 (B3VCF0_HUMAN)
  • cDNA, FLJ78929, highly similar to Beta-chimaerin (B3VCF1_HUMAN)
  • Beta chimaerin isoform B1-CHNdel ex7p,11 (B3VCF2_HUMAN)
genes like me logo Genes that share domains with CHN2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for CHN2 Gene

Function for CHN2 Gene

Molecular function for CHN2 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.
UniProtKB/Swiss-Prot EnzymeRegulation:
In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain, sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby activating the enzyme.
GENATLAS Biochemistry:
chimerin beta-2,GTPase activating protein for the ras-related p21rac,DAG (diacylglycerol) receptor,expressed in cerebellum,homolog to CHN1

Phenotypes From GWAS Catalog for CHN2 Gene

Gene Ontology (GO) - Molecular Function for CHN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS --
GO:0005096 GTPase activator activity IDA 8175705
GO:0005515 protein binding IPI 16628218
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CHN2: view
genes like me logo Genes that share phenotypes with CHN2: view

Animal Models for CHN2 Gene

MGI Knock Outs for CHN2:
  • Chn2 Chn2<tm1.1Alk>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHN2

Clone Products

  • Addgene plasmids for CHN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHN2 Gene

Localization for CHN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHN2 Gene

Membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHN2 gene
Compartment Confidence
cytosol 5
nucleus 2
lysosome 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0045202 synapse IDA 8175705
genes like me logo Genes that share ontologies with CHN2: view

Pathways & Interactions for CHN2 Gene

PathCards logo

SuperPathways for CHN2 Gene

SuperPathway Contained pathways
1 Cytoskeletal Signaling
2 Neuroscience
3 G12-G13 in Cellular Signaling
-
4 Actin Nucleation by ARP-WASP Complex
.35
5 RhoGDI Pathway
.33
genes like me logo Genes that share pathways with CHN2: view

Pathways by source for CHN2 Gene

2 BioSystems pathways for CHN2 Gene
2 GeneGo (Thomson Reuters) pathways for CHN2 Gene
  • G-protein signaling_Regulation of CDC42 activity
  • G-protein signaling_Regulation of RAC1 activity
3 Qiagen pathways for CHN2 Gene
  • G12-G13 in Cellular Signaling
  • RhoA Pathway
  • RhoGDI Pathway
2 Cell Signaling Technology pathways for CHN2 Gene

SIGNOR curated interactions for CHN2 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CHN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043087 regulation of GTPase activity IBA 21873635
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with CHN2: view

Drugs & Compounds for CHN2 Gene

(3) Additional Compounds for CHN2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with CHN2: view

Transcripts for CHN2 Gene

mRNA/cDNA for CHN2 Gene

14 REFSEQ mRNAs :
36 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHN2

Clone Products

  • Addgene plasmids for CHN2

Alternative Splicing Database (ASD) splice patterns (SP) for CHN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - -
SP2:
SP3:
SP4:
SP5: - -
SP6: -

Relevant External Links for CHN2 Gene

GeneLoc Exon Structure for
CHN2

Expression for CHN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHN2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x13.6) and Brain - Cerebellum (x9.7).

Protein differential expression in normal tissues from HIPED for CHN2 Gene

This gene is overexpressed in Fetal Brain (36.7) and Pancreas (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHN2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHN2

SOURCE GeneReport for Unigene cluster for CHN2 Gene:

Hs.654611

mRNA Expression by UniProt/SwissProt for CHN2 Gene:

P52757-CHIO_HUMAN
Tissue specificity: Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas.

Evidence on tissue expression from TISSUES for CHN2 Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Liver(2.4)
  • Skin(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with CHN2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHN2 Gene

Orthologs for CHN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHN2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CHN2 30 31
  • 99.22 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CHN2 31
  • 98 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CHN2 31
  • 95 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CHN2 31
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia CHN2 30 31
  • 92.09 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Chn2 30 17 31
  • 90.38 (n)
OneToOne
Chicken
(Gallus gallus)
Aves CHN2 30 31
  • 83.4 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CHN2 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia chn2 30
  • 77.3 (n)
Zebrafish
(Danio rerio)
Actinopterygii chn2 30 31
  • 71.9 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11065 30
Fruit Fly
(Drosophila melanogaster)
Insecta RhoGAP5A 31 32
  • 37 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea chin-1 30 31
  • 51.65 (n)
OneToMany
BE0003N10.2 32
  • 43 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 44 (a)
OneToMany
Species where no ortholog for CHN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CHN2 Gene

ENSEMBL:
Gene Tree for CHN2 (if available)
TreeFam:
Gene Tree for CHN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHN2: view image

Paralogs for CHN2 Gene

Paralogs for CHN2 Gene

(29) SIMAP similar genes for CHN2 Gene using alignment to 24 proteins:

  • CHIO_HUMAN
  • B3VCE9_HUMAN
  • B3VCF0_HUMAN
  • B3VCF4_HUMAN
  • B3VCF5_HUMAN
  • B3VCF6_HUMAN
  • B3VCF8_HUMAN
  • B3VCF9_HUMAN
  • B3VCG0_HUMAN
  • B3VCG2_HUMAN
  • B3VCG3_HUMAN
  • B3VCG4_HUMAN
  • B3VCG5_HUMAN
  • B7Z1V0_HUMAN
  • B7Z1W9_HUMAN
  • B8ZZU1_HUMAN
  • C9JQ94_HUMAN
  • F5GWP4_HUMAN
  • F5H003_HUMAN
  • H0YG02_HUMAN
  • H7C0V3_HUMAN
  • H7C138_HUMAN
  • J3KSU2_HUMAN
  • Q75MY2_HUMAN
genes like me logo Genes that share paralogs with CHN2: view

Variants for CHN2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHN2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
776213 Benign: not provided 29,512,640(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
rs34971642 - p.Pro438Ser
rs3750103 - p.His204Arg

Additional dbSNP identifiers (rs#s) for CHN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CHN2 Gene

Variant ID Type Subtype PubMed ID
dgv11248n54 CNV gain 21841781
dgv6312n100 CNV loss 25217958
esv2028870 CNV deletion 18987734
esv2194510 CNV deletion 18987734
esv2526582 CNV deletion 19546169
esv2659047 CNV deletion 23128226
esv2675235 CNV deletion 23128226
esv2734182 CNV deletion 23290073
esv2734183 CNV deletion 23290073
esv2734185 CNV deletion 23290073
esv2761314 CNV gain 21179565
esv2762661 CNV loss 21179565
esv33032 CNV gain 17666407
esv3306168 CNV mobile element insertion 20981092
esv3306644 CNV mobile element insertion 20981092
esv3309480 CNV mobile element insertion 20981092
esv3330105 CNV insertion 20981092
esv3336265 CNV insertion 20981092
esv3449687 CNV insertion 20981092
esv3541392 CNV deletion 23714750
esv3541394 CNV deletion 23714750
esv3612685 CNV loss 21293372
esv3612690 CNV loss 21293372
esv3612691 CNV loss 21293372
esv3612692 CNV loss 21293372
esv3612693 CNV loss 21293372
esv4539 CNV loss 18987735
nsv1019174 CNV gain 25217958
nsv1034932 CNV loss 25217958
nsv1109854 CNV deletion 24896259
nsv366043 CNV deletion 16902084
nsv477820 CNV novel sequence insertion 20440878
nsv5680 CNV insertion 18451855
nsv5681 CNV deletion 18451855
nsv830934 CNV gain 17160897
nsv970811 CNV duplication 23825009

Variation tolerance for CHN2 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.29; 76.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHN2 Gene

Human Gene Mutation Database (HGMD)
CHN2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHN2 Gene

Disorders for CHN2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CHN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatosplenic t-cell lymphoma
duodenum adenocarcinoma
  • duodenal adenocarcinoma
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search CHN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CHN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHN2 Gene

Publications for CHN2 Gene

  1. Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras-related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain. (PMID: 8175705) Leung T … Lim L (The Journal of biological chemistry 1994) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 41
  4. A Bayesian approach to genetic association studies with family-based designs. (PMID: 20818722) Naylor MG … Lange C (Genetic epidemiology 2010) 3 41
  5. Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. (PMID: 20460425) Maeda S … Nakamura Y (Diabetes 2010) 3 41

Products for CHN2 Gene

Sources for CHN2 Gene