Aliases for CHN2 Gene
External Ids for CHN2 Gene
Previous GeneCards Identifiers for CHN2 Gene
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]
GeneCards Summary for CHN2 Gene
CHN2 (Chimerin 2) is a Protein Coding gene. Diseases associated with CHN2 include Hepatosplenic T-Cell Lymphoma and Duodenum Adenocarcinoma. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is ENSG00000285162.
UniProtKB/Swiss-Prot Summary for CHN2 Gene
GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.