Aliases for CHMP7 Gene
Aliases for CHMP7 Gene
External Ids for CHMP7 Gene
- HGNC: 28439
- Entrez Gene: 91782
- Ensembl: ENSG00000147457
- OMIM: 611130
- UniProtKB: Q8WUX9
Previous GeneCards Identifiers for CHMP7 Gene
- GC08P023027
- GC08P023157
- GC08P021647
- GC08P023101
Summaries for CHMP7 Gene
GeneCards Summary for CHMP7 Gene
CHMP7 (Charged Multivesicular Body Protein 7) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include protein transporter activity.
UniProtKB/Swiss-Prot for CHMP7 Gene
-
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).
Additional gene information for CHMP7 Gene
- Monarch Initiative
- Search for CHMP7 at DataMed
- Search for CHMP7 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP7 Gene
Genomics for CHMP7 Gene
GeneHancer (GH) Regulatory Elements for CHMP7 Gene
Promoters and enhancers for CHMP7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CHMP7 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CHMP7 gene promoter:
-
- c-Jun
- ATF-2
- STAT1
- Sp1
- STAT1alpha
- STAT1beta
- POU2F1a
Regulatory Element Products
Genomic Locations for CHMP7 Gene
Genomic Locations for CHMP7 Gene
- chr8:23,243,637-23,262,000
- (GRCh38/hg38)
- Size:
- 18,364 bases
- Orientation:
- Plus strand
- chr8:23,101,150-23,119,512
- (GRCh37/hg19)
- Size:
- 18,363 bases
- Orientation:
- Plus strand
Genomic View for CHMP7 Gene
Genes around CHMP7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p21.3 by Entrez Gene
- 8p21.3 by HGNC
- 8p21.3 by Ensembl
CHMP7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHMP7 Gene
Proteins for CHMP7 Gene
-
Protein details for CHMP7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WUX9-CHMP7_HUMAN
- Recommended name:
- Charged multivesicular body protein 7
- Protein Accession:
- Q8WUX9
- B2RDT3
- B4DKJ6
- D3DSS1
- Q8NDM1
- Q9BT50
Protein attributes for CHMP7 Gene
- Size:
- 453 amino acids
- Molecular mass:
- 50911 Da
- Quaternary structure:
-
- Interacts with CHMP4B, but not with VPS25.
Protein Expression for CHMP7 Gene
Post-translational modifications for CHMP7 Gene
Other Protein References for CHMP7 Gene
Antibody Products
- Novus Biologicals Antibodies for CHMP7
- Invitrogen Antibodies for CHMP7 (AFLGC-CHMP7)
- Search GeneTex for Antibodies for CHMP7
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHMP7
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CHMP7
- Origene Custom Protein Services for CHMP7
- antibodies-online: Search results for 6 available CHMP7 Proteins ranked by validation data
- Compare Top CHMP7 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CHMP7
-
Abcam proteins for CHMP7
Assay Products
No data available for DME Specific Peptides for CHMP7 Gene
Domains & Families for CHMP7 Gene
Gene Families for CHMP7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for CHMP7 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CHMP7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8WUX9- Family:
-
- Belongs to the SNF7 family.
Function for CHMP7 Gene
Molecular function for CHMP7 Gene
- UniProtKB/Swiss-Prot Function:
- ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).
Phenotypes From GWAS Catalog for CHMP7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16856878 |
| GO:0008565 | protein transporter activity | IMP | 16856878 |
Phenotypes for CHMP7 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHMP7
-
CRISPR Products
-
OriGene CRISPR knockouts for CHMP7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHMP7
- genomics-online: gRNA clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
- Applied Biological Materials CRISPR for CHMP7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHMP7
- GenScript: Design CRISPR guide RNA sequences for CHMP7
miRNA for CHMP7 Gene
- miRTarBase miRNAs that target CHMP7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHMP7
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- genomics-online: shRNA clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CHMP7
- Addgene plasmids for CHMP7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHMP7
- Applied Biological Materials Clones for CHMP7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CHMP7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHMP7 Gene
Localization for CHMP7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHMP7 Gene
- Cytoplasm. Nucleus envelope. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area (PubMed:16856878). Localizes to the nucleus envelope during late anaphase (PubMed:26040712). {ECO:0000269 PubMed:16856878, ECO:0000269 PubMed:26040712}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endosome | 5 |
- Cytosol (3)
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | colocalizes_with chromatin | IDA | 28242692 |
| GO:0000815 | ESCRT III complex | NAS | 28242692 |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005635 | nuclear envelope | IEA,IDA | 26040712 |
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for CHMP7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.91
.64
|
.45
|
| 2 | Budding and maturation of HIV virion | ||
| 3 | Vesicle-mediated transport | ||
| 4 | Endocytosis | ||
| 5 | Necroptosis | ||
Pathways by source for CHMP7 Gene
11 Reactome pathways for CHMP7 Gene
2 KEGG pathways for CHMP7 Gene
Interacting Proteins for CHMP7 Gene
Selected Interacting proteins:
Q8WUX9-CHMP7_HUMAN
ENSP00000324491
for CHMP7 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CHMP7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000920 | cell separation after cytokinesis | IMP | 20616062 |
| GO:0006997 | nucleus organization | IMP | 20616062 |
| GO:0007034 | vacuolar transport | IEA | -- |
| GO:0007080 | mitotic metaphase plate congression | IMP | 20616062 |
| GO:0010458 | exit from mitosis | IMP | 26040712 |
No data available for SIGNOR curated interactions for CHMP7 Gene
Transcripts for CHMP7 Gene
mRNA/cDNA for CHMP7 Gene
- (10) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (312) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000397677 3403 bps (uc003xdc.3)
- ENST00000519414 914 bps (uc064ldu.1)
- ENST00000517325 2639 bps (uc064ldv.1)
- ENST00000519984 666 bps (uc064ldw.1)
- ENST00000519529 690 bps (uc064ldx.1)
Unigene Clusters for CHMP7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHMP7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHMP7
- genomics-online: gRNA clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
- Applied Biological Materials CRISPR for CHMP7
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHMP7
- GenScript: Design CRISPR guide RNA sequences for CHMP7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHMP7
- Browse OriGene Inhibitory RNA Products For CHMP7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHMP7
- genomics-online: shRNA clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
Clone Products
- Sino Biological Human cDNA Clone for CHMP7
- Addgene plasmids for CHMP7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHMP7
- Applied Biological Materials Clones for CHMP7
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
Expression for CHMP7 Gene
This gene is overexpressed in Lymph node (17.9), Peripheral blood mononuclear cells (17.4), and Blymphocyte (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHMP7 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CHMP7 Gene:
CHMP7SOURCE GeneReport for Unigene cluster for CHMP7 Gene:
Hs.5019Evidence on tissue expression from TISSUES for CHMP7 Gene
- Nervous system(3.8)
Primer Products
-
OriGene qPCR primer pairs for CHMP7
-
OriGene qPCR primer pairs and template standards for CHMP7
- genomics-online: primer clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHMP7 Gene
Orthologs for CHMP7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHMP7 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CHMP7 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CHMP7 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CHMP7 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Chmp7 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Chmp7 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHMP7 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHMP7 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CHMP7 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | chmp7 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | chmp7 34 33 |
|
OneToOne | |
| zgc73300 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012459 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5498 34 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | T24B8.2 34 33 |
|
OneToOne |
- Species where no ortholog for CHMP7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for CHMP7 Gene
- ENSEMBL:
- Gene Tree for CHMP7 (if available)
- TreeFam:
- Gene Tree for CHMP7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CHMP7: view image
Paralogs for CHMP7 Gene
(1) SIMAP similar genes for CHMP7 Gene using alignment to 5 proteins:
- CHMP7_HUMAN
- B4DKJ6_HUMAN
- E5RFR8_HUMAN
- E5RIU9_HUMAN
- E5RJI3_HUMAN
No data available for Paralogs for CHMP7 Gene
Variants for CHMP7 Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000189918 | -- | 23,262,139(+) | G/A | downstream_transcript_variant | |
| rs1000328485 | -- | 23,262,004(+) | C/T | downstream_transcript_variant | |
| rs1000371901 | -- | 23,262,138(+) | C/A/T | downstream_transcript_variant | |
| rs1000492217 | -- | 23,258,029(+) | C/T | intron_variant | |
| rs1000533343 | -- | 23,251,934(+) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2736756 | CNV | deletion | 23290073 |
| esv2759604 | CNV | loss | 17122850 |
| nsv1017570 | CNV | gain | 25217958 |
| nsv1027718 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.52;
29.54% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHMP7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CHMP7
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP7 Gene
Disorders for CHMP7 Gene
Additional Disease Information for CHMP7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CHMP7 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHMP7 Gene
Publications for CHMP7 Gene
- CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway. (PMID: 16856878) Horii M … Maki M (The Biochemical journal 2006) 2 3 4 58
- Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. (PMID: 26040712) Vietri M … Stenmark H (Nature 2015) 3 4 58
- Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for CHMP7 Gene
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- Novus Biologicals
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- antibodies-online: Search results for 6 available CHMP7 Proteins ranked by validation data
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- Quality Products:
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- Horizon Cell Lines for CHMP7
- genomics-online: cdna clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
- orf clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
- genomics-online: gRNA clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
- genomics-online: primer clones - Search results for 125 available CHMP7 gene related products
- Overview of 125 available CHMP7 gene related products
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- Overview of 125 available CHMP7 gene related products
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Sources for CHMP7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
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