Aliases for CHMP6 Gene
External Ids for CHMP6 Gene
Previous GeneCards Identifiers for CHMP6 Gene
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]
GeneCards Summary for CHMP6 Gene
CHMP6 (Charged Multivesicular Body Protein 6) is a Protein Coding gene. Diseases associated with CHMP6 include Frontotemporal Dementia, Chromosome 3-Linked. Among its related pathways are Budding and maturation of HIV virion and Necroptosis. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.
UniProtKB/Swiss-Prot Summary for CHMP6 Gene
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.