Aliases for CHMP2B Gene
- Charged Multivesicular Body Protein 2B 2 3 5
- Charged Multivesicular Body Protein 2b 3 4
- Chromatin Modifying Protein 2B 2 3
- CHMP2.5 3 4
- Vacuolar Protein-Sorting-Associated Protein 2-2 3
- Vacuolar Protein Sorting-Associated Protein 2-2 4
- Chromatin-Modifying Protein 2b 4
- VPS2 Homolog B (S. Cerevisiae) 2
External Ids for CHMP2B Gene
Previous GeneCards Identifiers for CHMP2B Gene
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHMP2B Gene
CHMP2B (Charged Multivesicular Body Protein 2B) is a Protein Coding gene. Diseases associated with CHMP2B include Frontotemporal Dementia, Chromosome 3-Linked and Amyotrophic Lateral Sclerosis 17. Among its related pathways are Budding and maturation of HIV virion and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is CHMP2A.
UniProtKB/Swiss-Prot Summary for CHMP2B Gene
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.