CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distr... See more...

Aliases for CHMP2A Gene

Aliases for CHMP2A Gene

  • Charged Multivesicular Body Protein 2A 2 3 5
  • CHMP2 2 3 4
  • Vacuolar Protein Sorting-Associated Protein 2-1 3 4
  • Putative Breast Adenocarcinoma Marker (32kD) 2 3
  • Putative Breast Adenocarcinoma Marker BC-2 3 4
  • Charged Multivesicular Body Protein 2a 3 4
  • Chromatin Modifying Protein 2A 2 3
  • Vps2-1 3 4
  • VPS2A 2 3
  • BC-2 2 3
  • VPS2 2 3
  • BC2 3 4
  • VPS2 Homolog A (S. Cerevisiae) 2
  • Chromatin-Modifying Protein 2a 4
  • VPS2 Homolog A 3
  • HVps2-1 4
  • CHMP2A 5
  • CHMP2a 4

External Ids for CHMP2A Gene

Previous GeneCards Identifiers for CHMP2A Gene

  • GC19M063755
  • GC19M059062
  • GC19M055373

Summaries for CHMP2A Gene

Entrez Gene Summary for CHMP2A Gene

  • CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHMP2A Gene

CHMP2A (Charged Multivesicular Body Protein 2A) is a Protein Coding gene. Diseases associated with CHMP2A include Viral Gastritis and Breast Adenocarcinoma. Among its related pathways are Budding and maturation of HIV virion and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include protein domain specific binding and phosphatidylcholine binding. An important paralog of this gene is CHMP2B.

UniProtKB/Swiss-Prot Summary for CHMP2A Gene

  • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
  • (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.

Gene Wiki entry for CHMP2A Gene

Additional gene information for CHMP2A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHMP2A Gene

Genomics for CHMP2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CHMP2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J058553 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.9 -1945 8.1 SP1 HNRNPL CREB1 ATF7 PRDM10 ZNF629 TFE3 RFX1 SIX5 LEF1 MZF1-AS1 CHMP2A UBE2M lnc-CHMP2A-1 lnc-TRIM28-13 TRIM28 ZNF606 ZNF417 ZNF134 MZF1
GH19J058517 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.1 +35.9 35916 4.9 BRCA1 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 ZBTB45 lnc-SLC27A5-1 piR-47519 SLC27A5 ZNF324B ZNF446 TRIM28 ZNF135 ZNF134 ZNF549
GH19J058580 Enhancer 0.9 ENCODE 12.3 -25.6 -25640 1.5 BRCA1 CTCF ZBTB33 LEF1 BACH1 JUND ZNF143 PKNOX1 ZNF24 REST lnc-TRIM28-14 piR-36647 TRIM28 ZNF274 ZNF417 ENSG00000267216 RPL23AP79 ZNF587 ZBTB45 ZNF586
GH19J058522 Enhancer 0.4 Ensembl dbSUPER 13.1 +32.6 32624 0.4 ZNF7 TRIM28 CHMP2A UBE2M MZF1 RPL23AP79 CENPBD1P1 RNU6-1337P ZNF446 ZNF324 ZNF324B
GH19J058525 Enhancer 0.2 Ensembl 13.1 +30.0 30023 0.8 RF00017-3101 UBE2M CHMP2A MZF1 RPL23AP79 CENPBD1P1 RNU6-1337P ZNF446 ZNF324 ZNF324B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHMP2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHMP2A

Top Transcription factor binding sites by QIAGEN in the CHMP2A gene promoter:
  • AML1a

Genomic Locations for CHMP2A Gene

Genomic Locations for CHMP2A Gene
chr19:58,551,566-58,555,624
(GRCh38/hg38)
Size:
4,059 bases
Orientation:
Minus strand
chr19:59,062,933-59,066,491
(GRCh37/hg19)
Size:
3,559 bases
Orientation:
Minus strand

Genomic View for CHMP2A Gene

Genes around CHMP2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHMP2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHMP2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP2A Gene

Proteins for CHMP2A Gene

  • Protein details for CHMP2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43633-CHM2A_HUMAN
    Recommended name:
    Charged multivesicular body protein 2a
    Protein Accession:
    O43633
    Secondary Accessions:
    • B2R4W6
    • Q3ZTT0

    Protein attributes for CHMP2A Gene

    Size:
    222 amino acids
    Molecular mass:
    25104 Da
    Quaternary structure:
    • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. In vitro, heteromerizes with CHMP3 (but not CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A.
    Miscellaneous:
    • Its overexpression strongly inhibits HIV-1 release.

neXtProt entry for CHMP2A Gene

Post-translational modifications for CHMP2A Gene

  • ISGylated in a CHMP5-dependent manner. Isgylation weakens and inhibits its interactions with VPS4A and VTA1 respectively.
  • Ubiquitination at Lys52, Lys64, Lys89, Lys94, Lys104, Lys108, Lys118, and Lys124
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CHMP2A Gene

Domains & Families for CHMP2A Gene

Gene Families for CHMP2A Gene

Protein Domains for CHMP2A Gene

InterPro:
Blocks:
  • Eukaryotic protein of unknown function DUF279
ProtoNet:

Suggested Antigen Peptide Sequences for CHMP2A Gene

GenScript: Design optimal peptide antigens:
  • Vacuolar protein sorting-associated protein 2-1 (CHM2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43633

UniProtKB/Swiss-Prot:

CHM2A_HUMAN :
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
  • Belongs to the SNF7 family.
Domain:
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components.
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP2A: view

Function for CHMP2A Gene

Molecular function for CHMP2A Gene

UniProtKB/Swiss-Prot Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
UniProtKB/Swiss-Prot Function:
(Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.

Phenotypes From GWAS Catalog for CHMP2A Gene

Gene Ontology (GO) - Molecular Function for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14505570
GO:0019904 protein domain specific binding IPI 17928862
GO:0031210 phosphatidylcholine binding IMP 18687924
genes like me logo Genes that share ontologies with CHMP2A: view
genes like me logo Genes that share phenotypes with CHMP2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHMP2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHMP2A Gene

Localization for CHMP2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP2A Gene

Late endosome membrane. Peripheral membrane protein. Cytoplasmic side. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHMP2A gene
Compartment Confidence
nucleus 5
endosome 5
cytosol 5
extracellular 4
plasma membrane 3
cytoskeleton 2
mitochondrion 2
lysosome 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 colocalizes_with chromatin IDA 28242692
GO:0000815 ESCRT III complex IBA,TAS 20588296
GO:0005623 cell IEA --
GO:0005635 nuclear envelope IDA 26040712
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with CHMP2A: view

Pathways & Interactions for CHMP2A Gene

genes like me logo Genes that share pathways with CHMP2A: view

SIGNOR curated interactions for CHMP2A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CHMP2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
GO:0007080 mitotic metaphase plate congression IMP 20616062
GO:0010324 membrane invagination IMP 24878737
GO:0010458 exit from mitosis IMP 26040712
genes like me logo Genes that share ontologies with CHMP2A: view

Drugs & Compounds for CHMP2A Gene

No Compound Related Data Available

Transcripts for CHMP2A Gene

mRNA/cDNA for CHMP2A Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHMP2A

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP2A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: - - - -

Relevant External Links for CHMP2A Gene

GeneLoc Exon Structure for
CHMP2A

Expression for CHMP2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHMP2A Gene

mRNA differential expression in normal tissues according to GTEx for CHMP2A Gene

This gene is overexpressed in Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for CHMP2A Gene

This gene is overexpressed in Urine (17.8), Peripheral blood mononuclear cells (8.2), and Cervix (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHMP2A Gene



Protein tissue co-expression partners for CHMP2A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHMP2A

SOURCE GeneReport for Unigene cluster for CHMP2A Gene:

Hs.12107

Evidence on tissue expression from TISSUES for CHMP2A Gene

  • Skin(4.6)
  • Liver(4.6)
  • Muscle(4.6)
  • Blood(4.5)
  • Nervous system(3.8)
  • Kidney(3.1)
  • Intestine(3)
  • Heart(3)
  • Spleen(2.8)
  • Lung(2.8)
  • Lymph node(2.5)
  • Stomach(2.5)
  • Bone marrow(2.5)
  • Thyroid gland(2.4)
  • Adrenal gland(2.2)
  • Eye(2.1)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with CHMP2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHMP2A Gene

Orthologs for CHMP2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHMP2A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CHMP2A 30 31
  • 99.55 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Chmp2a 30
  • 90.99 (n)
Mouse
(Mus musculus)
Mammalia Chmp2a 30 17 31
  • 90.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CHMP2A 30 31
  • 90.54 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CHMP2A 30 31
  • 88.59 (n)
OneToOne
Chicken
(Gallus gallus)
Aves -- 31
  • 85 (a)
OneToMany
CHMP2A 30
  • 80.61 (n)
-- 31
  • 78 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia CHMP2A 31
  • 93 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia chmp2a 30
  • 77.12 (n)
Str.7485 30
Zebrafish
(Danio rerio)
Actinopterygii bc2 30 31
  • 73.79 (n)
OneToOne
Dr.2361 30
Fruit Fly
(Drosophila melanogaster)
Insecta vps2 30 31
  • 72.77 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001285 30
  • 72.08 (n)
Worm
(Caenorhabditis elegans)
Secernentea vps-2 30 31
  • 66.67 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ABR002C 30
  • 55.37 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13343g 30
  • 55.37 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DID4 30 31 33
  • 52.28 (n)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons VPS2.1 30
  • 62.61 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2446 30
Rice
(Oryza sativa)
Liliopsida Os07g0236800 30
  • 63.24 (n)
Barley
(Hordeum vulgare)
Liliopsida Hv.7386 30
Wheat
(Triticum aestivum)
Liliopsida Ta.2133 30
Corn
(Zea mays)
Liliopsida Zm.5893 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 68 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU00435 30
  • 58.29 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes did4 30
  • 48.17 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3979 30
Species where no ortholog for CHMP2A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for CHMP2A Gene

ENSEMBL:
Gene Tree for CHMP2A (if available)
TreeFam:
Gene Tree for CHMP2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHMP2A: view image

Paralogs for CHMP2A Gene

Paralogs for CHMP2A Gene

(4) SIMAP similar genes for CHMP2A Gene using alignment to 4 proteins:

  • CHM2A_HUMAN
  • M0QXX8_HUMAN
  • M0R1L7_HUMAN
  • M0R1T5_HUMAN
genes like me logo Genes that share paralogs with CHMP2A: view

Variants for CHMP2A Gene

Additional dbSNP identifiers (rs#s) for CHMP2A Gene

Structural Variations from Database of Genomic Variants (DGV) for CHMP2A Gene

Variant ID Type Subtype PubMed ID
dgv3687n100 CNV gain 25217958
dgv3688n100 CNV gain 25217958
nsv1057077 CNV gain 25217958
nsv1057206 CNV gain 25217958
nsv1160670 CNV deletion 26073780
nsv515731 CNV gain+loss 19592680
nsv820066 CNV loss 19587683
nsv828657 CNV gain 20364138
nsv952156 CNV deletion 24416366

Variation tolerance for CHMP2A Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHMP2A Gene

Human Gene Mutation Database (HGMD)
CHMP2A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHMP2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHMP2A Gene

Disorders for CHMP2A Gene

MalaCards: The human disease database

(3) MalaCards diseases for CHMP2A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
viral gastritis
breast adenocarcinoma
  • adenocarcinoma of breast
frontotemporal dementia, chromosome 3-linked
  • ftd3
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with CHMP2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHMP2A Gene

Publications for CHMP2A Gene

  1. Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. (PMID: 18385515) Shim S … Hanson PI (Molecular biology of the cell 2008) 3 4 23
  2. Helical structures of ESCRT-III are disassembled by VPS4. (PMID: 18687924) Lata S … Weissenhorn W (Science (New York, N.Y.) 2008) 3 4 23
  3. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PMID: 11559748) Howard TL … Hollenberg SM (Journal of cell science 2001) 2 3 4
  4. Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. (PMID: 26040712) Vietri M … Stenmark H (Nature 2015) 3 4
  5. Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. (PMID: 21543490) Kuang Z … Leis J (Journal of virology 2011) 3 4

Products for CHMP2A Gene

  • Signalway Proteins for CHMP2A

Sources for CHMP2A Gene