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CHKB Gene(Protein Coding)

Choline Kinase Beta

GCID:
GC22M050578
GIFtS:
53
Genes Participants
UDN Logo

Aliases for CHKB Gene

Aliases for CHKB Gene

  • Choline Kinase Beta 2 3 4 5
  • Choline Kinase-Like Protein 3 4
  • Ethanolamine Kinase Beta 3 4
  • CHETK 3 4
  • CKEKB 3 4
  • CHKL 3 4
  • CKB 3 4
  • EKB 3 4
  • CK 3 4
  • EK 3 4
  • Choline/Ethanolamine Kinase Beta 4
  • Choline/Ethanolamine Kinase 3
  • Ethanolamine Kinase 4
  • Choline Kinase-Like 2
  • EC 2.7.1.32 4
  • EC 2.7.1.82 4
  • MDCMC 3

External Ids for CHKB Gene

Previous HGNC Symbols for CHKB Gene

  • CHKL

Previous GeneCards Identifiers for CHKB Gene

  • GC22M049149
  • GC22M049298
  • GC22M049307
  • GC22M049364
  • GC22M051007
  • GC22M033908
  • GC22M051017

Summaries for CHKB Gene

Entrez Gene Summary for CHKB Gene

  • Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009]

GeneCards Summary for CHKB Gene

CHKB (Choline Kinase Beta) is a Protein Coding gene. Diseases associated with CHKB include Muscular Dystrophy, Congenital, Megaconial Type and Myoblastoma. Among its related pathways are Metabolism and Glycerophospholipid Biosynthetic Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and choline kinase activity. An important paralog of this gene is CHKA.

UniProtKB/Swiss-Prot for CHKB Gene

  • Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.

Gene Wiki entry for CHKB Gene

Additional gene information for CHKB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHKB Gene

Genomics for CHKB Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CHKB Gene

Promoters and enhancers for CHKB Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22I050581 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 575.5 +18.9 18925 2.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 FOS CHKB CHKB-AS1 CHKB-CPT1B CPT1B MAPK8IP2
GH22I050600 Promoter 1.7 EPDnew Ensembl 550.8 +0.8 754 0.6 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ZNF766 GLIS2 CHKB MAPK8IP2 CPT1B
GH22I050601 Enhancer 1 ENCODE 550.8 +1.2 1168 0.1 ATF1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ZNF766 CHKB MAPK8IP2 ENSG00000272940
GH22I050626 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 30.9 -26.6 -26568 2.4 HDGF ZNF493 ARID4B SIN3A YBX1 GLI4 ZNF2 ZNF280A GLIS2 KLF7 ARSA BRD1 ZBED4 RABL2B ENSG00000272836 TUBGCP6 PLXNB2 ALG12 CHKB LOC105373095
GH22I050339 Enhancer 0.9 ENCODE 46 +261.2 261231 2.1 HDGF ZNF493 ZNF2 KLF7 ZNF488 ZNF585B GLIS1 MYNN NBN ZNF300 BRD1 RABL2B ALG12 PLXNB2 ENSG00000272836 CHKB TUBGCP6 ZBED4 LMF2 ENSG00000273192
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHKB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHKB gene promoter:

Genomic Locations for CHKB Gene

Genomic Locations for CHKB Gene
chr22:50,578,949-50,601,455
(GRCh38/hg38)
Size:
22,507 bases
Orientation:
Minus strand
chr22:51,017,378-51,039,884
(GRCh37/hg19)

Genomic View for CHKB Gene

Genes around CHKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHKB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHKB Gene

Proteins for CHKB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y259-CHKB_HUMAN
    Recommended name:
    Choline/ethanolamine kinase
    Protein Accession:
    Q9Y259
    Secondary Accessions:
    • A0PJM6
    • Q13388

    Protein attributes for CHKB Gene

    Size:
    395 amino acids
    Molecular mass:
    45271 Da
    Quaternary structure:
    • Homodimer, and heterodimer with CHKA.
    Miscellaneous:
    • This protein is produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame.
    SequenceCaution:
    • Sequence=AAB03342.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHKB Gene

    Alternative splice isoforms for CHKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHKB Gene

Protein Expression for CHKB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CHKB Gene

No Post-translational modifications

Other Protein References for CHKB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHKB Gene

Domains & Families for CHKB Gene

Gene Families for CHKB Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CHKB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CHKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y259

UniProtKB/Swiss-Prot:

CHKB_HUMAN :
  • Belongs to the choline/ethanolamine kinase family.
Family:
  • Belongs to the choline/ethanolamine kinase family.
genes like me logo Genes that share domains with CHKB: view

Function for CHKB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CHKB Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.57 mM for choline {ECO:0000269 PubMed:19915674}; KM=2.9 mM for ethanolamine {ECO:0000269 PubMed:19915674};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + choline = ADP + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot Function:
Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.

Enzyme Numbers (IUBMB) for CHKB Gene

Phenotypes From GWAS Catalog for CHKB Gene

Gene Ontology (GO) - Molecular Function for CHKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004103 choline kinase activity TAS --
GO:0004305 ethanolamine kinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with CHKB: view
genes like me logo Genes that share phenotypes with CHKB: view

Human Phenotype Ontology for CHKB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for CHKB Gene

miRTarBase miRNAs that target CHKB

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CHKB

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CHKB Gene

Localization for CHKB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHKB gene
Compartment Confidence
cytosol 4
mitochondrion 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHKB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CHKB Gene

Pathways & Interactions for CHKB Gene

genes like me logo Genes that share pathways with CHKB: view

UniProtKB/Swiss-Prot Q9Y259-CHKB_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.

Gene Ontology (GO) - Biological Process for CHKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway IEA --
GO:0008654 phospholipid biosynthetic process IEA --
genes like me logo Genes that share ontologies with CHKB: view

No data available for SIGNOR curated interactions for CHKB Gene

Drugs & Compounds for CHKB Gene

Products:

  1. Drug

(91) Drugs for CHKB Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Enzyme, substrate 176
Ethanolamine Experimental Pharma 0
Phosphorylcolamine Experimental Pharma 0
ATP Investigational Nutra Agonist 0

(59) Additional Compounds for CHKB Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
phosphorylcholine
  • Choline phosphate
  • N-Trimethyl-2-aminoethylphosphonate
  • O-Phosphocholine
  • Phosphocholine
  • Phosphoryl-choline
 3616-04-4
genes like me logo Genes that share compounds with CHKB: view

Transcripts for CHKB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CHKB Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHKB Gene

Choline kinase beta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CHKB

Alternative Splicing Database (ASD) splice patterns (SP) for CHKB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ·
SP1: - - - - - - -
SP2:
SP3:
SP4:
SP5: - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - -
SP9: - - - - - -
SP10:
SP11:
SP12: - - - - -
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22: - -
SP23: -
SP24:
SP25:
SP26:
SP27:
SP28: -
SP29:

ExUns: 13c ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d · 17e ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b ^ 21a · 21b ^
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - - - - - - -
SP11:
SP12:
SP13: - - - - - - - - -
SP14: - - - - - -
SP15:
SP16: - - - -
SP17: - - - -
SP18: - - - -
SP19: - - - - -
SP20: - - - -
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:

ExUns: 22a · 22b · 22c ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34a · 34b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:
SP14:
SP15: - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: -
SP28:
SP29:

Relevant External Links for CHKB Gene

GeneLoc Exon Structure for
CHKB
ECgene alternative splicing isoforms for
CHKB

Expression for CHKB Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHKB Gene

mRNA expression in normal human tissues for CHKB Gene
mRNA expression by GTEx for CHKB GenemRNA expression by BioGPS for CHKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CHKB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHKB Gene



Protein tissue co-expression partners for CHKB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHKB Gene:

CHKB

SOURCE GeneReport for Unigene cluster for CHKB Gene:

Hs.654827

Evidence on tissue expression from TISSUES for CHKB Gene

  • Blood(4)
  • Lung(4)
  • Nervous system(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CHKB Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
  • nervous
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • face
  • head
  • skull
Thorax:
  • heart
  • heart valve
Limb:
  • lower limb
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with CHKB: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHKB Gene

Orthologs for CHKB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CHKB 33 34
  • 99.58 (n)
dog
(Canis familiaris)
 Mammalia CHKB 33
  • 89.28 (n)
-- 34
  • 85 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia CHKB 33 34
  • 88.95 (n)
rat
(Rattus norvegicus)
 Mammalia Chkb 33
  • 85.58 (n)
mouse
(Mus musculus)
 Mammalia Chkb 33 16 34
  • 85.11 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 76 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 65 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 65 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia chkb 33
  • 60.59 (n)
zebrafish
(Danio rerio)
 Actinopterygii chkb 33 34
  • 62.95 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007957 33
  • 53.09 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG2201 33 34
  • 49.46 (n)
worm
(Caenorhabditis elegans)
 Secernentea cka-1 33 34
  • 49.95 (n)
cka-2 34
  • 37 (a)
 ManyToMany
ckb-1 34
  • 25 (a)
 ManyToMany
ckb-4 34
  • 25 (a)
 ManyToMany
ckb-2 34
  • 24 (a)
 ManyToMany
ckb-3 34
  • 24 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CKI1 34
  • 16 (a)
 ManyToMany
EKI1 34
  • 16 (a)
 ManyToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT1G74320 33
  • 46.89 (n)
rice
(Oryza sativa)
 Liliopsida Os05g0535400 33
  • 50 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 34
  • 39 (a)
 OneToMany
Species where no ortholog for CHKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHKB Gene

ENSEMBL:
Gene Tree for CHKB (if available)
TreeFam:
Gene Tree for CHKB (if available)

Paralogs for CHKB Gene

Paralogs for CHKB Gene

(2) SIMAP similar genes for CHKB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHKB: view

Variants for CHKB Gene

Sequence variations from dbSNP and Humsavar for CHKB Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1056964 likely-benign, Congenital Muscular Dystrophy, CHKB-related 50,579,047(-) A/C/G/T 3_prime_UTR_variant
rs112742765 uncertain-significance, Congenital Muscular Dystrophy, CHKB-related 50,579,055(-) G/A/C 3_prime_UTR_variant
rs114094125 uncertain-significance, Congenital Muscular Dystrophy, CHKB-related 50,582,878(-) C/G 5_prime_UTR_variant
rs138205828 uncertain-significance, likely-benign, benign, Congenital Muscular Dystrophy, CHKB-related, not specified, Muscular dystrophy, congenital, megaconial type 50,582,633(-) T/C coding_sequence_variant, missense_variant
rs140867913 uncertain-significance, Congenital Muscular Dystrophy, CHKB-related 50,582,307(-) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CHKB Gene

Variant ID Type Subtype PubMed ID
nsv955202 CNV deletion 24416366
nsv834239 CNV loss 17160897
nsv829340 CNV gain 20364138
nsv589223 CNV loss 21841781
nsv589222 CNV gain 21841781
nsv471224 CNV loss 18288195
nsv1059234 CNV gain 25217958
nsv1057656 CNV gain 25217958
esv2758852 CNV loss 17122850

Variation tolerance for CHKB Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHKB Gene

Human Gene Mutation Database (HGMD)
CHKB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHKB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHKB Gene

Disorders for CHKB Gene

MalaCards: The human disease database

(31) MalaCards diseases for CHKB Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
muscular dystrophy, congenital, megaconial type
  • mdcmc
myoblastoma
  • benign granular cell tumor
anterolateral myocardial infarction
  • anterior wall myocardial infarction
compartment syndrome
  • compartmental syndrome, nos
fainting
- elite association - COSMIC cancer census association via MalaCards
Search CHKB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHKB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CHKB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHKB Gene

Publications for CHKB Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) Ruaño G … Wu AH (Pharmacogenomics 2010) 3 44 58
  3. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PMID: 18996102) Ruaño G … Hanks S (Clinica chimica acta; international journal of clinical chemistry 2009) 3 44 58
  4. Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). (PMID: 19404393) Miyagawa T … Tokunaga K (PloS one 2009) 3 44 58
  5. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. (PMID: 19915674) Gallego-Ortega D … Lacal JC (PloS one 2009) 3 4 58

Products for CHKB Gene

  • Addgene plasmids for CHKB

Sources for CHKB Gene

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