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Aliases for CHKA Gene

Aliases for CHKA Gene

  • Choline Kinase Alpha 2 3 3 5
  • Ethanolamine Kinase 3 4
  • CHETK-Alpha 3 4
  • CHK 3 4
  • CKI 3 4
  • CK 3 4
  • EK 3 4
  • Choline Kinase 2
  • EC 4
  • EC 4

External Ids for CHKA Gene

Previous HGNC Symbols for CHKA Gene

  • CHK

Previous GeneCards Identifiers for CHKA Gene

  • GC11M067596
  • GC11M067576
  • GC11M067820
  • GC11M064155

Summaries for CHKA Gene

Entrez Gene Summary for CHKA Gene

  • The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHKA Gene

CHKA (Choline Kinase Alpha) is a Protein Coding gene. Diseases associated with CHKA include Small Cell Carcinoma Of The Bladder and Hepatitis C Virus. Among its related pathways are Metabolism and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and obsolete signal transducer activity. An important paralog of this gene is CHKB.

UniProtKB/Swiss-Prot for CHKA Gene

  • Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Gene Wiki entry for CHKA Gene

Additional gene information for CHKA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHKA Gene

Genomics for CHKA Gene

GeneHancer (GH) Regulatory Elements for CHKA Gene

Promoters and enhancers for CHKA Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J068114 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.9 1936 9.2 HDGF PKNOX1 CLOCK SMAD1 ARNT MLX ARID4B SIN3A DMAP1 ZBTB7B CHKA KMT5B ENSG00000255031 LOC105369362 ANKRD13D NDUFS8 TCIRG1 ACY3 GC11M068058
GH11J068296 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -176.9 -176866 3.3 PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 LRP5 C11orf24 CHKA LOC105369363
GH11J068125 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -6.5 -6529 4 FOXA2 MLX ARID4B DMAP1 YY1 MCM3 SP3 RXRA SP5 MXD4 PPP6R3 MRGPRF ENSG00000255031 CLCF1 MRGPRF-AS1 TPCN2 LOC105369362 CORO1B ENSG00000261625 ENSG00000260808
GH11J068141 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 2.4 -20.9 -20898 1.5 MAX EBF1 ATF2 POLR2A EED IKZF1 ATF7 IKZF2 MYC ZFX PIR54954 ENSG00000255031 NDUFS8 CHKA GC11M068148
GH11J068471 Enhancer 1.1 FANTOM5 Ensembl ENCODE 2.3 -350.7 -350676 1.9 HDGF PKNOX1 ZNF146 MAX EBF1 POLR2A EGR1 ATF7 RUNX3 IKZF2 PPP6R3 TCIRG1 CHKA KMT5B IGHMBP2 GC11P068486
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHKA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHKA gene promoter:
  • NRSF form 2
  • NRSF form 1
  • AP-1
  • c-Jun
  • ATF-2

Genomic Locations for CHKA Gene

Genomic Locations for CHKA Gene
68,586 bases
Minus strand
68,586 bases
Minus strand

Genomic View for CHKA Gene

Genes around CHKA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHKA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHKA Gene

Proteins for CHKA Gene

  • Protein details for CHKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choline kinase alpha
    Protein Accession:
    Secondary Accessions:
    • Q8NE29

    Protein attributes for CHKA Gene

    457 amino acids
    Molecular mass:
    52249 Da
    Quaternary structure:
    • Heterodimer with CHKB (By similarity). Homodimer.

    Three dimensional structures from OCA and Proteopedia for CHKA Gene

    Alternative splice isoforms for CHKA Gene


neXtProt entry for CHKA Gene

Post-translational modifications for CHKA Gene

  • Ubiquitination at posLast=195195
  • Modification sites at PhosphoSitePlus

Other Protein References for CHKA Gene

No data available for DME Specific Peptides for CHKA Gene

Domains & Families for CHKA Gene

Gene Families for CHKA Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CHKA Gene

Suggested Antigen Peptide Sequences for CHKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the choline/ethanolamine kinase family.
  • Belongs to the choline/ethanolamine kinase family.
genes like me logo Genes that share domains with CHKA: view

Function for CHKA Gene

Molecular function for CHKA Gene

UniProtKB/Swiss-Prot Function:
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + choline = ADP + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for choline {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=0.4 mM for ATP {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=12 mM for ethanolamine {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674};

Enzyme Numbers (IUBMB) for CHKA Gene

Gene Ontology (GO) - Molecular Function for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004103 choline kinase activity TAS --
GO:0004104 cholinesterase activity IEA --
GO:0004305 ethanolamine kinase activity TAS --
GO:0004871 obsolete signal transducer activity TAS --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CHKA: view
genes like me logo Genes that share phenotypes with CHKA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHKA

miRNA for CHKA Gene

miRTarBase miRNAs that target CHKA

Clone Products

  • Addgene plasmids for CHKA

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHKA Gene

Localization for CHKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHKA Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHKA gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHKA: view

Pathways & Interactions for CHKA Gene

genes like me logo Genes that share pathways with CHKA: view

Pathways by source for CHKA Gene

UniProtKB/Swiss-Prot P35790-CHKA_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.
  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.

Gene Ontology (GO) - Biological Process for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006580 ethanolamine metabolic process IEA --
GO:0006629 lipid metabolic process TAS 10363580
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway IEA --
genes like me logo Genes that share ontologies with CHKA: view

No data available for SIGNOR curated interactions for CHKA Gene

Drugs & Compounds for CHKA Gene

(50) Drugs for CHKA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Enzyme, substrate 176
Choline salicylate Approved Nutra Enzyme, substrate 0
Ethanolamine Experimental Pharma 0
Phosphorylcolamine Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(36) Additional Compounds for CHKA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
  • Choline phosphate
  • CHOP
  • N-Trimethyl-2-aminoethylphosphonate
  • O-Phosphocholine
  • Phosphoryl-choline
  • (2-Acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
Phosphatidylcholines Group B
  • 1-Hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine
  • 2-(9Z,12Z-Octadecadienoyl)-1-hexadecyl-sn-glycero-3-phosphocholine
  • PC Ae C34:2
  • PC(16:0E/18:2(9Z,12Z))
  • PC(O-34:2)
genes like me logo Genes that share compounds with CHKA: view

Transcripts for CHKA Gene

mRNA/cDNA for CHKA Gene

Unigene Clusters for CHKA Gene

Choline kinase alpha:
Representative Sequences:

Clone Products

  • Addgene plasmids for CHKA

Alternative Splicing Database (ASD) splice patterns (SP) for CHKA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d
SP1: - - - - -
SP2: - - - - - -
SP5: -

Relevant External Links for CHKA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHKA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHKA Gene

Protein differential expression in normal tissues from HIPED for CHKA Gene

This gene is overexpressed in Lung (55.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHKA Gene

Protein tissue co-expression partners for CHKA Gene

NURSA nuclear receptor signaling pathways regulating expression of CHKA Gene:


SOURCE GeneReport for Unigene cluster for CHKA Gene:


Evidence on tissue expression from TISSUES for CHKA Gene

  • Nervous system(2.7)
  • Liver(2)
genes like me logo Genes that share expression patterns with CHKA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHKA Gene

Orthologs for CHKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHKA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHKA 34 33
  • 99.74 (n)
(Canis familiaris)
Mammalia CHKA 34 33
  • 88.6 (n)
(Bos Taurus)
Mammalia CHKA 34 33
  • 88.07 (n)
(Rattus norvegicus)
Mammalia Chka 33
  • 86.44 (n)
(Mus musculus)
Mammalia Chka 16 34 33
  • 86.39 (n)
(Ornithorhynchus anatinus)
Mammalia CHKA 34
  • 76 (a)
(Monodelphis domestica)
Mammalia CHKA 34
  • 74 (a)
(Gallus gallus)
Aves CHKA 34 33
  • 75.88 (n)
(Anolis carolinensis)
Reptilia CHKA 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chka 33
  • 68.64 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12834 33
(Danio rerio)
Actinopterygii chka 34 33
  • 70.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2201 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea cka-2 34 33
  • 51.96 (n)
cka-1 34
  • 30 (a)
ckb-1 34
  • 27 (a)
ckb-4 34
  • 25 (a)
ckb-3 34
  • 24 (a)
ckb-2 34
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EKI1 36 34
  • 17 (a)
CKI1 34
  • 17 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons CK1 33
  • 46.39 (n)
(Oryza sativa)
Liliopsida Os01g0183000 33
  • 48.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
Species where no ortholog for CHKA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHKA Gene

Gene Tree for CHKA (if available)
Gene Tree for CHKA (if available)
Evolutionary constrained regions (ECRs) for CHKA: view image

Paralogs for CHKA Gene

Paralogs for CHKA Gene

(2) SIMAP similar genes for CHKA Gene using alignment to 3 proteins:

  • E9PM06_HUMAN
  • H0YD02_HUMAN
genes like me logo Genes that share paralogs with CHKA: view

Variants for CHKA Gene

Sequence variations from dbSNP and Humsavar for CHKA Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000010515 -- 68,117,333(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000048065 -- 68,068,778(-) C/G intron_variant
rs1000072308 -- 68,063,444(-) G/A intron_variant
rs1000100528 -- 68,114,236(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000114152 -- 68,103,068(-) T/C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHKA Gene

Variant ID Type Subtype PubMed ID
dgv1221n100 CNV gain 25217958
dgv1983n54 CNV loss 21841781
esv2677355 CNV deletion 23128226
esv2759835 CNV gain+loss 17122850
esv3626732 CNV loss 21293372
nsv1070047 CNV deletion 25765185
nsv1143691 CNV deletion 24896259
nsv371 CNV deletion 18451855
nsv469856 CNV gain 16826518
nsv469964 CNV loss 18288195
nsv825963 CNV gain 20364138
nsv825965 CNV gain 20364138
nsv951026 CNV deletion 24416366

Variation tolerance for CHKA Gene

Residual Variation Intolerance Score: 28.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHKA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHKA Gene

Disorders for CHKA Gene

MalaCards: The human disease database

(6) MalaCards diseases for CHKA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
small cell carcinoma of the bladder
  • poorly differentiated neuroendocrine carcinoma of the bladder
hepatitis c virus
  • hepatitis c virus, susceptibility to
muscle disorders
  • myopathy
  • muscular diseases
microinvasive gastric cancer
  • early gastric cancer
- elite association - COSMIC cancer census association via MalaCards
Search CHKA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHKA

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CHKA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHKA Gene

Publications for CHKA Gene

  1. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. (PMID: 19915674) Gallego-Ortega D … Lacal JC (PloS one 2009) 3 4 22 58
  2. Structure and function of choline kinase isoforms in mammalian cells. (PMID: 15003397) Aoyama C … Ishidate K (Progress in lipid research 2004) 2 3 22 58
  3. Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation. (PMID: 1618328) Hosaka K … Yamashita S (FEBS letters 1992) 2 3 4 58
  4. Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity. (PMID: 20299452) Hong BS … Park HW (The Journal of biological chemistry 2010) 3 4 58
  5. Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts. (PMID: 20662904) Mostowska A … Jagodzinski PP (European journal of oral sciences 2010) 3 44 58

Products for CHKA Gene

Sources for CHKA Gene