Aliases for CHKA Gene
External Ids for CHKA Gene
Previous HGNC Symbols for CHKA Gene
Previous GeneCards Identifiers for CHKA Gene
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHKA Gene
CHKA (Choline Kinase Alpha) is a Protein Coding gene. Diseases associated with CHKA include Small Cell Carcinoma Of The Bladder and Hepatitis C Virus. Among its related pathways are Metabolism and Phospholipase D signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and obsolete signal transducer activity. An important paralog of this gene is CHKB.
UniProtKB/Swiss-Prot for CHKA Gene
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.