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Aliases for CHID1 Gene

Aliases for CHID1 Gene

  • Chitinase Domain Containing 1 2 3 5
  • SI-CLP 3 4
  • Stabilin-1 Interacting Chitinase-Like Protein 3
  • Stabilin-1-Interacting Chitinase-Like Protein 4
  • Chitinase Domain-Containing Protein 1 3
  • GL008 3
  • SICLP 3

External Ids for CHID1 Gene

Previous GeneCards Identifiers for CHID1 Gene

  • GC11M000683

Summaries for CHID1 Gene

GeneCards Summary for CHID1 Gene

CHID1 (Chitinase Domain Containing 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and chitinase activity.

UniProtKB/Swiss-Prot for CHID1 Gene

  • Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).

Additional gene information for CHID1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHID1 Gene

Genomics for CHID1 Gene

GeneHancer (GH) Regulatory Elements for CHID1 Gene

Promoters and enhancers for CHID1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J000909 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 660.3 +4.2 4221 2.5 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 YY1 GLIS2 ELK1 ZNF207 CHID1 RNU6-1025P KRTAP5-AS1 GC11P000900
GH11J000914 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 111 1.5 FOXA2 PKNOX1 MLX ARID4B DMAP1 ZNF48 YY1 NFKBIZ RXRA REST CHID1 GC11P000900
GH11J000839 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.2 +71.3 71277 7.6 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 TSPAN4 POLR2L GC11M000841 CD151 TMEM80 PIDD1 SNORA52 RPLP2 ENSG00000255237 RIC8A
GH11J000824 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 4.9 +87.8 87757 6.4 HDGF PKNOX1 ARID4B SIN3A DMAP1 POLR2B ZNF207 ZNF143 SP3 SP5 CRACR2B PIR51142 CD151 ENSG00000255108 RPLP2 LOC171391 CHID1 POLR2L B4GALNT4 PNPLA2
GH11J000849 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 5.1 +65.0 64963 2.5 HDGF ZBTB10 CTCF MXI1 USF1 SIN3A GATAD2B ZIC2 ZBTB7B ZNF335 TSPAN4 CD151 CHID1 POLR2L ENSG00000250397
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHID1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHID1 gene promoter:
  • Gfi-1
  • Meis-1b
  • Meis-1a
  • Meis-1
  • Arnt
  • p53
  • ATF6
  • MAZR

Genomic Locations for CHID1 Gene

Genomic Locations for CHID1 Gene
47,200 bases
Minus strand
47,702 bases
Minus strand

Genomic View for CHID1 Gene

Genes around CHID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHID1 Gene

Proteins for CHID1 Gene

  • Protein details for CHID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chitinase domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KWB0
    • Q8NBM9
    • Q96CZ3
    • Q96S93
    • Q96SK0
    • Q9BY52

    Protein attributes for CHID1 Gene

    393 amino acids
    Molecular mass:
    44941 Da
    Quaternary structure:
    • Interacts with STAB1.

    Three dimensional structures from OCA and Proteopedia for CHID1 Gene

    Alternative splice isoforms for CHID1 Gene


neXtProt entry for CHID1 Gene

Post-translational modifications for CHID1 Gene

  • Ubiquitination at Lys361
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CHID1 Gene

Domains & Families for CHID1 Gene

Gene Families for CHID1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CHID1 Gene

Suggested Antigen Peptide Sequences for CHID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 18 family.
  • Belongs to the glycosyl hydrolase 18 family.
genes like me logo Genes that share domains with CHID1: view

Function for CHID1 Gene

Molecular function for CHID1 Gene

UniProtKB/Swiss-Prot Function:
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4/interleukin-4 and dexamethasone in the macrophages. Up-regulated by glucocorticoid.

Phenotypes From GWAS Catalog for CHID1 Gene

Gene Ontology (GO) - Molecular Function for CHID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004568 chitinase activity IBA --
GO:0005515 protein binding IPI 16357325
GO:0008061 chitin binding IBA --
GO:0070492 oligosaccharide binding IPI 20724479
genes like me logo Genes that share ontologies with CHID1: view
genes like me logo Genes that share phenotypes with CHID1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHID1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHID1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHID1 Gene

Localization for CHID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHID1 Gene

Secreted. Lysosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHID1 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 5
golgi apparatus 5
endosome 5
cytoskeleton 2
mitochondrion 2
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 16357325
GO:0005634 nucleus HDA 21630459
GO:0005764 lysosome IDA,IEA 16357325
GO:0005770 late endosome IDA 16357325
genes like me logo Genes that share ontologies with CHID1: view

Pathways & Interactions for CHID1 Gene

genes like me logo Genes that share pathways with CHID1: view

Interacting Proteins for CHID1 Gene

Gene Ontology (GO) - Biological Process for CHID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0005975 carbohydrate metabolic process IEA --
GO:0006032 chitin catabolic process IBA --
GO:0045087 innate immune response IEA --
GO:1900016 negative regulation of cytokine production involved in inflammatory response IDA 20724479
genes like me logo Genes that share ontologies with CHID1: view

No data available for SIGNOR curated interactions for CHID1 Gene

Drugs & Compounds for CHID1 Gene

No Compound Related Data Available

Transcripts for CHID1 Gene

Unigene Clusters for CHID1 Gene

Chitinase domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHID1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHID1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP5: - -
SP6: -
SP9: -

Relevant External Links for CHID1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHID1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHID1 Gene

Protein differential expression in normal tissues from HIPED for CHID1 Gene

This gene is overexpressed in Spleen (8.5), Peripheral blood mononuclear cells (7.3), and Salivary gland (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHID1 Gene

Protein tissue co-expression partners for CHID1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHID1 Gene:


SOURCE GeneReport for Unigene cluster for CHID1 Gene:


mRNA Expression by UniProt/SwissProt for CHID1 Gene:

Tissue specificity: Expressed in cells of monocytic, T, B and epithelial origin.

Evidence on tissue expression from TISSUES for CHID1 Gene

  • Nervous system(4.9)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with CHID1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHID1 Gene

Orthologs for CHID1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHID1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHID1 34 33
  • 99.69 (n)
(Canis familiaris)
Mammalia CHID1 34 33
  • 87.7 (n)
(Rattus norvegicus)
Mammalia LOC100911881 33
  • 87.53 (n)
(Mus musculus)
Mammalia Chid1 16 34 33
  • 86.77 (n)
(Bos Taurus)
Mammalia CHID1 34 33
  • 84.31 (n)
(Ornithorhynchus anatinus)
Mammalia CHID1 34
  • 42 (a)
(Monodelphis domestica)
Mammalia CHID1 34
  • 35 (a)
(Gallus gallus)
Aves CHID1 34 33
  • 66.33 (n)
(Anolis carolinensis)
Reptilia CHID1 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chid1 33
  • 64.8 (n)
(Danio rerio)
Actinopterygii chid1 34 33
  • 57.72 (n)
wufb02e07 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008124 33
  • 52.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8460 34 33
  • 51.79 (n)
(Caenorhabditis elegans)
Secernentea chil-10 34
  • 27 (a)
chil-14 34
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G01040 33
  • 49.95 (n)
(Oryza sativa)
Liliopsida Os01g0619800 33
  • 49.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2914 34
  • 46 (a)
Species where no ortholog for CHID1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHID1 Gene

Gene Tree for CHID1 (if available)
Gene Tree for CHID1 (if available)
Evolutionary constrained regions (ECRs) for CHID1: view image

Paralogs for CHID1 Gene

(75) SIMAP similar genes for CHID1 Gene using alignment to 15 proteins:

  • E9PI70_HUMAN
  • E9PJ91_HUMAN
  • H0YC89_HUMAN
genes like me logo Genes that share paralogs with CHID1: view

No data available for Paralogs for CHID1 Gene

Variants for CHID1 Gene

Sequence variations from dbSNP and Humsavar for CHID1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000075417 -- 880,567(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000113020 -- 893,442(-) G/A coding_sequence_variant, intron_variant, missense_variant
rs1000118894 -- 886,972(-) C/T intron_variant
rs1000188214 -- 891,354(-) T/A/G intron_variant
rs1000215750 -- 877,440(-) TCTCTCT/TCT genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHID1 Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv175e214 CNV gain 21293372
dgv182e199 CNV deletion 23128226
esv1667682 CNV insertion 17803354
esv2663667 CNV deletion 23128226
esv2669189 CNV deletion 23128226
esv2671662 CNV deletion 23128226
esv2743878 CNV deletion 23290073
esv2743879 CNV deletion 23290073
esv2743880 CNV deletion 23290073
esv2759794 CNV loss 17122850
esv32950 CNV gain 17666407
esv3310451 CNV novel sequence insertion 20981092
esv3337474 CNV insertion 20981092
esv3428658 CNV insertion 20981092
esv3625086 CNV loss 21293372
esv3625087 CNV gain 21293372
esv3625088 CNV gain 21293372
esv3625089 CNV loss 21293372
nsv1040044 CNV gain+loss 25217958
nsv1048774 CNV gain 25217958
nsv1159791 CNV deletion 26073780
nsv428244 CNV loss 18775914
nsv469923 CNV loss 18288195
nsv476328 CNV novel sequence insertion 20440878
nsv552871 CNV loss 21841781
nsv552887 CNV loss 21841781
nsv832044 CNV loss 17160897
nsv951272 CNV deletion 24416366

Variation tolerance for CHID1 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHID1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHID1 Gene

Disorders for CHID1 Gene

Additional Disease Information for CHID1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CHID1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHID1 Gene

Publications for CHID1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Structure of human stabilin-1 interacting chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity. (PMID: 20724479) Meng G … Zheng X (The Journal of biological chemistry 2010) 3 4 58
  3. Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. (PMID: 16357325) Kzhyshkowska J … Goerdt S (Blood 2006) 3 4 58
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for CHID1 Gene

Sources for CHID1 Gene

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