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This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]
CHIC2 (Cysteine Rich Hydrophobic Domain 2) is a Protein Coding gene. Diseases associated with CHIC2 include Leukemia, Acute Myeloid and Clivus Meningioma. An important paralog of this gene is CHIC1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0005798 | Golgi-associated vesicle | IEA,IBA | 21873635 |
GO:0005886 | plasma membrane | IDA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031410 | cytoplasmic vesicle | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008150 | biological_process | ND | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | CHIC2 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | CHIC2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CHIC2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CHIC2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Chic2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Chic2 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | CHIC2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CHIC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CHIC2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | chic2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.32435 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | chic2 30 31 |
|
OneToOne | |
zgc55670 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5938 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001278 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | tag-266 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
leukemia, acute myeloid |
|
|
clivus meningioma |
|
|
myeloid and lymphoid neoplasms associated with pdgfra rearrangement |
|
|
myeloid leukemia |
|
|
cebpa-associated familial acute myeloid leukemia |
|
|