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The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefS... See more...
Aliases for CHIA Gene
Aliases for CHIA Gene
External Ids for CHIA Gene
- HGNC: 17432
- Entrez Gene: 27159
- Ensembl: ENSG00000134216
- OMIM: 606080
- UniProtKB: Q9BZP6
Previous GeneCards Identifiers for CHIA Gene
- GC01P112249
- GC01P110695
- GC01P110935
- GC01P111132
- GC01P111545
- GC01P111636
- GC01P111833
- GC01P109706
Summaries for CHIA Gene
-
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for CHIA Gene
CHIA (Chitinase Acidic) is a Protein Coding gene. Diseases associated with CHIA include Asthma and Gaucher Disease, Type I. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is CHIT1.
UniProtKB/Swiss-Prot Summary for CHIA Gene
-
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
Additional gene information for CHIA Gene
- HGNC(17432)
- Entrez Gene(27159)
- Ensembl(ENSG00000134216)
- OMIM(606080)
- UniProtKB(Q9BZP6)
- Open Targets Platform(ENSG00000134216)
- Monarch Initiative
- Search for CHIA at DataMed
- Search for CHIA at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHIA Gene
Genomics for CHIA Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CHIA Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J111290 | Promoter | 0.5 | EPDnew | 623.2 | 0.0 | -18 | 0.1 | SCRT2 YY1 | CHIA CHIAP2 DENND2D | |
| GH01J111275 | Enhancer | 0.7 | Ensembl ENCODE | 11.2 | -15.6 | -15550 | 1.4 | SCRT2 RUNX3 USF1 FOSL1 FOXA1 MNT USF2 | CHIAP2 CHIA CHIAP1 DENND2D | |
| GH01J111320 | Enhancer | 0.3 | Ensembl | 5.2 | +29.9 | 29850 | 1 | ZBTB33 SPI1 | CHIA ENSG00000229283 ENSG00000232240 PIFO lnc-CHIA-1 piR-47402-004 | |
| GH01J111212 | Promoter/Enhancer | 2.1 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 0.2 | -69.4 | -69404 | 18.7 | SP1 CREB1 GATAD2A CTCF ATF7 PRDM10 ZNF629 TFE3 ZNF512 LEF1 | CHI3L2 DDX20 ENSG00000229283 ENSG00000232240 PIFO WDR77 ATP5PB OVGP1 DENND2D CEPT1 | |
| GH01J111234 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 0.2 | -54.6 | -54598 | 4.3 | CEBPG GATAD2A SOX13 ZHX2 RXRB CEBPA CTBP1 TGIF2 FOXA2 ZNF592 | CHI3L2 DENND2D ENSG00000229283 ENSG00000232240 OVGP1 ATP5PB WDR77 HSALNG0006031 piR-31162-028 CHIA |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CHIA on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHIA
- Top Transcription factor binding sites by QIAGEN in the CHIA gene promoter:
-
- AML1a
- C/EBPalpha
- Pax-6
- TBP
- TFIID
Genomic Locations for CHIA Gene
Genomic Locations for CHIA Gene
- chr1:111,290,851-111,320,566
- (GRCh38/hg38)
- Size:
- 29,716 bases
- Orientation:
- Plus strand
- chr1:111,833,484-111,863,188
- (GRCh37/hg19)
- Size:
- 29,705 bases
- Orientation:
- Plus strand
Genomic View for CHIA Gene
Genes around CHIA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
CHIA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHIA Gene
Proteins for CHIA Gene
-
Protein details for CHIA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BZP6-CHIA_HUMAN
- Recommended name:
- Acidic mammalian chitinase
- Protein Accession:
- Q9BZP6
- Q32W79
- Q32W80
- Q3B866
- Q5U5Z5
- Q5VUV4
- Q86UD8
- Q9ULY3
- Q9ULY4
Protein attributes for CHIA Gene
- Size:
- 476 amino acids
- Molecular mass:
- 52271 Da
- Quaternary structure:
-
- Interacts with EGFR.
Three dimensional structures from OCA and Proteopedia for CHIA Gene
Protein Expression for CHIA Gene
Selected DME Specific Peptides for CHIA Gene
- Q9BZP6:
-
- CYFTNWA
- GYTGENSPLYK
- LCTHLIY
- NGAPAEKLI
- LAIGGWN
Post-translational modifications for CHIA Gene
Other Protein References for CHIA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for CHIA
-
Abcam antibodies for CHIA
- Invitrogen Antibodies for CHIA (AFLGC-CHIA)
-
Boster Bio Antibodies for CHIA
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHIA
- Sino Biological Antibodies for CHIA
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CHIA
- Origene Custom Protein Services for CHIA
- antibodies-online: Show 6 available CHIA Proteins ranked by validation data
- Compare Top CHIA Proteins
-
Quality Products:
-
Abcam proteins for CHIA
Assay Products
- antibodies-online: Show 15 available CHIA Elisa Kits ranked by validation data
- Compare Top CHIA Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for CHIA
Domains & Families for CHIA Gene
Gene Families for CHIA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CHIA Gene
- InterPro:
- Blocks:
-
- Glycoside hydrolase, family 18
- Glycoside hydrolase, family 18/2
- Chitinase II
- Chitin binding Peritrophin-A
- ProtoNet:
Suggested Antigen Peptide Sequences for CHIA Gene
- GenScript: Design optimal peptide antigens:
-
- CHIA protein (A5D6V7_HUMAN)
- Lung-specific protein TSA1902 (CHIA_HUMAN)
- Chitinase, acidic (Q5VUV3_HUMAN)
- Chitinase, acidic (Q5VUV5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9BZP6UniProtKB/Swiss-Prot:
CHIA_HUMAN :- Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.
- Family:
-
- Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.
Function for CHIA Gene
Molecular function for CHIA Gene
- UniProtKB/Swiss-Prot Function:
- Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.; EC=3.2.1.14; Evidence={ECO:0000269|PubMed:18824549, ECO:0000269|PubMed:19241384, ECO:0000269|PubMed:19435888};.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in lung epithelial cells from asthma patients.
Enzyme Numbers (IUBMB) for CHIA Gene
Phenotypes From GWAS Catalog for CHIA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds | IEA | -- |
| GO:0004568 | chitinase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 18824549 |
| GO:0008061 | chitin binding | IBA | 21873635 |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for CHIA Gene
- MGI mutant phenotypes for CHIA:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CHIA:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased viability
- Increased gamma-H2AX phosphorylation
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Increased viability
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Decreased homologous recombination repair frequency
Animal Models for CHIA Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CHIA
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CHIA - Select products 50% OFF >
- * CHIA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CHIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHIA
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHIA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHIA
- Browse OriGene Inhibitory RNA Products For CHIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHIA
Clone Products
- Applied Biological Materials (abm): Clones for CHIA - Select products 50% OFF >
- * CHIA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- RC206441
- RC206441L3
- RC206441L4
- RC221549
- RC221549L1
- RC221549L2
- RC221549L3
- RC221549L4
- RC233733
- RC233736
- RC233737
- RC233738
- RC233892
- RC233893
- RG206441
- RG221549
- RG233733
- RG233736
- RG233737
- RG233738
- RG233892
- RG233893
- RR201701
- RR201701L3
- RR201701L4
- RC206441L3V
- RC206441L4V
- RC221549L1V
- RC221549L2V
- RC221549L3V
- RC221549L4V
- RR201701L3V
- RR201701L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CHIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHIA
Cell Line Products
-
Horizon Cell Lines for CHIA
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHIA Gene
Localization for CHIA Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHIA Gene
- [Isoform 1]: Secreted. Note=Secretion depends on EGFR activity.
- [Isoform 2]: Cytoplasm.
- [Isoform 3]: Cytoplasm.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IBA,TAS | -- |
| GO:0005615 | extracellular space | IDA | 18824549 |
| GO:0005737 | cytoplasm | NAS | 10548734 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHIA Gene
Pathways & Interactions for CHIA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | Amino sugar and nucleotide sugar metabolism | ||
| 3 | Glycosaminoglycan metabolism | ||
Pathways by source for CHIA Gene
2 Reactome pathways for CHIA Gene
2 KEGG pathways for CHIA Gene
Interacting Proteins for CHIA Gene
Selected Interacting proteins:
Q9BZP6-CHIA_HUMAN
ENSP00000358755
for CHIA Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for CHIA
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000272 | polysaccharide catabolic process | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002532 | production of molecular mediator involved in inflammatory response | IDA | 18824549 |
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006030 | chitin metabolic process | NAS | 10548734 |
No data available for SIGNOR curated interactions for CHIA Gene
Drugs & Compounds for CHIA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1512 | ||
| Water | Approved | Pharma | 0 | |||
| N-Acetyl-D-glucosamine | Approved, Investigational | Nutra | 0 | |||
| 2-acetylamino-2-deoxy-b-D-allopyranose | Experimental | Pharma | Target | 0 | ||
| Allosamidin | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for CHIA Gene
mRNA/cDNA for CHIA Gene
- 8 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000422815 1354 nts (view in UCSC)
- ENST00000483391 1188 nts (view in UCSC)
- ENST00000369740 1696 nts (view in UCSC)
- ENST00000352594 1482 nts (view in UCSC)
- ENST00000477918 4250 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CHIA - Select products 50% OFF >
- * CHIA CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CHIA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHIA
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHIA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHIA
- Browse OriGene Inhibitory RNA Products For CHIA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHIA
Clone Products
- Applied Biological Materials (abm): Clones for CHIA - Select products 50% OFF >
- * CHIA as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- RC206441
- RC206441L3
- RC206441L4
- RC221549
- RC221549L1
- RC221549L2
- RC221549L3
- RC221549L4
- RC233733
- RC233736
- RC233737
- RC233738
- RC233892
- RC233893
- RG206441
- RG221549
- RG233733
- RG233736
- RG233737
- RG233738
- RG233892
- RG233893
- RR201701
- RR201701L3
- RR201701L4
- RC206441L3V
- RC206441L4V
- RC221549L1V
- RC221549L2V
- RC221549L3V
- RC221549L4V
- RR201701L3V
- RR201701L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CHIA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHIA
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | - |
Relevant External Links for CHIA Gene
- GeneLoc Exon Structure for
- CHIA
Expression for CHIA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for CHIA Gene
This gene is overexpressed in Stomach (x50.5).
This gene is overexpressed in Heart (30.6), Prostate (20.7), and Rectum (17.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHIA Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHIA
SOURCE GeneReport for Unigene cluster for CHIA Gene:
Hs.128814mRNA Expression by UniProt/SwissProt for CHIA Gene:
Q9BZP6-CHIA_HUMAN
Tissue specificity:
Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.
Evidence on tissue expression from TISSUES for CHIA Gene
- Lung(4.5)
- Kidney(4.5)
- Stomach(3.8)
- Skin(2.7)
- Blood(2.3)
- Nervous system(2.2)
- Intestine(2)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for CHIA
-
OriGene qPCR primer pairs and template standards for CHIA
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHIA Gene
Orthologs for CHIA Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | CHIA 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CHIA 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Chia1 30 17 |
|
||
| Chia 31 |
|
OneToMany | |||
| Chi3l3 31 |
|
OneToMany | |||
| Chi3l4 31 |
|
OneToMany | |||
| Chi3l7 31 |
|
OneToMany | |||
| BC051070 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Chia 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Chicken (Gallus gallus) |
Aves | CHIA 30 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | chia 30 |
|
||
| Str.8480 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:173927 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Cht7 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | cht-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CTS2 31 33 33 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU03209 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8046 31 |
|
OneToMany |
- Species where no ortholog for CHIA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CHIA Gene
- ENSEMBL:
- Gene Tree for CHIA (if available)
- TreeFam:
- Gene Tree for CHIA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CHIA: view image
Paralogs for CHIA Gene
(5) SIMAP similar genes for CHIA Gene using alignment to 5 proteins:
- CHIA_HUMAN
- A5D6V7_HUMAN
- E9PLJ2_HUMAN
- H7BXH6_HUMAN
- Q5VUV5_HUMAN
Pseudogenes.org Pseudogenes for CHIA Gene
Variants for CHIA Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHIA Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 711968 | Benign: not provided | 111,318,516(+) | G/A | SYNONYMOUS_VARIANT | |
| 711969 | Benign: not provided | 111,318,646(+) | G/A | MISSENSE_VARIANT | |
| 711970 | Benign: not provided | 111,319,154(+) | G/A | MISSENSE_VARIANT | |
| 711971 | Benign: not provided | 111,319,359(+) | C/T | SYNONYMOUS_VARIANT | |
| 720744 | Benign: not provided | 111,315,429(+) | G/C | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv18n111 | CNV | deletion | 26073780 |
| dgv31e201 | CNV | deletion | 23290073 |
| dgv81e212 | CNV | loss | 25503493 |
| esv1564747 | CNV | deletion | 17803354 |
| esv2665968 | CNV | deletion | 23128226 |
| esv2716163 | CNV | deletion | 23290073 |
| esv2716185 | CNV | deletion | 23290073 |
| esv2758960 | CNV | loss | 17122850 |
| esv3578103 | CNV | loss | 25503493 |
| esv3587180 | CNV | loss | 21293372 |
| esv3587181 | CNV | loss | 21293372 |
| nsv1005303 | CNV | gain | 25217958 |
| nsv1145360 | CNV | deletion | 24896259 |
| nsv441709 | CNV | loss | 18776908 |
| nsv463250 | CNV | loss | 19166990 |
| nsv518232 | CNV | loss | 19592680 |
| nsv547535 | CNV | loss | 21841781 |
| nsv547536 | CNV | gain+loss | 21841781 |
| nsv547537 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
95.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
17.14;
98.07% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHIA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHIA Gene
Disorders for CHIA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| asthma |
|
|
| gaucher disease, type i |
|
Search CHIA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CHIA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CHIA Gene
Publications for CHIA Gene
- Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. (PMID: 11085997) Boot RG … Aerts JM (The Journal of biological chemistry 2001) 2 3 4 23
- Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism. (PMID: 19342690) Hartl D … Elias JA (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 23
- Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. (PMID: 19435888) Seibold MA … Burchard EG (The Journal of biological chemistry 2009) 3 4 23
- Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels. (PMID: 18602573) Chatterjee R … Ghosh B (The Journal of allergy and clinical immunology 2008) 3 23 41
- Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. (PMID: 15192232) Zhu Z … Elias JA (Science (New York, N.Y.) 2004) 3 4 23
ExternalLinks
Products for CHIA Gene
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Sources for CHIA Gene
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