Aliases for CHIA Gene
External Ids for CHIA Gene
Previous GeneCards Identifiers for CHIA Gene
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for CHIA Gene
CHIA (Chitinase Acidic) is a Protein Coding gene. Diseases associated with CHIA include Asthma and Gaucher Disease, Type I. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and hydrolase activity, hydrolyzing O-glycosyl compounds. An important paralog of this gene is CHIT1.
UniProtKB/Swiss-Prot Summary for CHIA Gene
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.