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The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
CHI3L2 (Chitinase 3 Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and chitin binding. An important paralog of this gene is CHIT1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004568 | NOT chitinase activity | IDA, IBA | 22742450 |
GO:0008061 | chitin binding | IBA,IDA | 22742450 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0030246 | carbohydrate binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IBA | 21873635 |
GO:0005615 | extracellular space | TAS,HDA | 16502470 |
GO:0005737 | cytoplasm | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0006032 | chitin catabolic process | IBA | 21873635 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CHI3L2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CHI3L2 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | CHI3L2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG2989 32 |
|
|
|
CG9357 32 |
|
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CG10531 32 |
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Cht3 32 |
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Cht1 32 |
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Cht2 32 |
|
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CG3044 32 |
|
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Idgf4 32 |
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Chit 32 |
|
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Cht7 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | cht-1 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CTS2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8046 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
723214 | Benign: not provided | 111,242,359(+) | C/T | SYNONYMOUS_VARIANT | |
725533 | Likely Benign: not provided | 111,230,935(+) | C/T | SYNONYMOUS_VARIANT | |
769524 | Benign: not provided | 111,235,708(+) | G/A | MISSENSE_VARIANT | |
rs13721 | Benign: not specified. - | 111,241,360(+) | C/Tp.Arg318Trp | MISSENSE_VARIANT | |
rs1553176789 | Uncertain Significance: not provided | 111,242,348(+) | GC/G | FRAMESHIFT_VARIANT |
No disorders were found for CHI3L2 Gene.