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The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] See more...
Aliases for CHI3L2 Gene
Aliases for CHI3L2 Gene
External Ids for CHI3L2 Gene
- HGNC: 1933
- Entrez Gene: 1117
- Ensembl: ENSG00000064886
- OMIM: 601526
- UniProtKB: Q15782
Previous GeneCards Identifiers for CHI3L2 Gene
- GC01P112186
- GC01P110642
- GC01P110872
- GC01P111069
- GC01P111482
- GC01P111571
- GC01P111770
- GC01P109641
Summaries for CHI3L2 Gene
-
The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for CHI3L2 Gene
CHI3L2 (Chitinase 3 Like 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and chitin binding. An important paralog of this gene is CHIT1.
UniProtKB/Swiss-Prot Summary for CHI3L2 Gene
-
Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
Additional gene information for CHI3L2 Gene
- HGNC(1933)
- Entrez Gene(1117)
- Ensembl(ENSG00000064886)
- OMIM(601526)
- UniProtKB(Q15782)
- Open Targets Platform(ENSG00000064886)
- Search for CHI3L2 at DataMed
- Search for CHI3L2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHI3L2 Gene
Genomics for CHI3L2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CHI3L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CHI3L2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHI3L2
- Top Transcription factor binding sites by QIAGEN in the CHI3L2 gene promoter:
-
- AML1a
- E47
- Ik-3
- LCR-F1
- NF-AT
- Tal-1
Genomic Locations for CHI3L2 Gene
Genomic Locations for CHI3L2 Gene
- chr1:111,200,771-111,243,440
- (GRCh38/hg38)
- Size:
- 42,670 bases
- Orientation:
- Plus strand
- chr1:111,743,393-111,786,062
- (GRCh37/hg19)
- Size:
- 42,670 bases
- Orientation:
- Plus strand
Genomic View for CHI3L2 Gene
Genes around CHI3L2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.2 by HGNC
- 1p13.2 by Entrez Gene
- 1p13.2 by Ensembl
CHI3L2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHI3L2 Gene
Proteins for CHI3L2 Gene
-
Protein details for CHI3L2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15782-CH3L2_HUMAN
- Recommended name:
- Chitinase-3-like protein 2
- Protein Accession:
- Q15782
- A6NNY3
- B4DPR7
- Q15749
- Q15783
- Q5VUV7
- Q96F97
Protein attributes for CHI3L2 Gene
- Size:
- 390 amino acids
- Molecular mass:
- 43501 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB04534.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAC50597.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for CHI3L2 Gene
Protein Expression for CHI3L2 Gene
Post-translational modifications for CHI3L2 Gene
Other Protein References for CHI3L2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- GeneTex Anti-YKL-39 antibody [N1C3] and Anti-YKL-39 antibody
-
Custom Antibody ServicesOriGene Antibodies for CHI3L2
- Novus Biologicals Antibodies for CHI3L2
- Invitrogen Antibodies for CHI3L2 (AFLGC-CHI3L2)
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Protein Products
- G Biosciences Human Chitinase-3-like protein 2/CHI3L2, Lyophilized
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-
ProSci Proteins for CHI3L2
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Abcam proteins for CHI3L2
Assay Products
- RayBiotech Custom Human CHI3L2 ELISA
- antibodies-online: Show 9 available CHI3L2 Elisa Kits ranked by validation data
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Quality Products:
-
Signalway ELISA kits for CHI3L2
No data available for DME Specific Peptides for CHI3L2 Gene
Domains & Families for CHI3L2 Gene
Gene Families for CHI3L2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for CHI3L2 Gene
- InterPro:
- Blocks:
-
- Glycoside hydrolase, family 18
- Glycoside hydrolase, family 18/2
- Chitinase II
- ProtoNet:
Suggested Antigen Peptide Sequences for CHI3L2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ57554, highly similar to Chitinase 3-like protein 2 (B4DPR7_HUMAN)
- YKL-39 (CH3L2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q15782- Family:
-
- Belongs to the glycosyl hydrolase 18 family.
Function for CHI3L2 Gene
Molecular function for CHI3L2 Gene
- UniProtKB/Swiss-Prot Function:
- Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.
- GENATLAS Biochemistry:
- chitinase 3-like 2,expressed in chondrocytes,synovial cell,lung,heart
Phenotypes From GWAS Catalog for CHI3L2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004568 | NOT chitinase activity | IDA, IBA | 22742450 |
| GO:0008061 | chitin binding | IBA,IDA | 22742450 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0030246 | carbohydrate binding | IEA | -- |
Phenotypes for CHI3L2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CHI3L2 - Select products 50% OFF >
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-
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miRNA for CHI3L2 Gene
- miRTarBase miRNAs that target CHI3L2
miRNA Products
Inhibitory RNA Products
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for CHI3L2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHI3L2 Gene
Localization for CHI3L2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHI3L2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IBA | 21873635 |
| GO:0005615 | extracellular space | TAS,HDA | 16502470 |
| GO:0005737 | cytoplasm | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHI3L2 Gene
Pathways & Interactions for CHI3L2 Gene
Interacting Proteins for CHI3L2 Gene
GPS-Prot Interaction Network for CHI3L2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0006032 | chitin catabolic process | IBA | 21873635 |
No data available for Pathways by source and SIGNOR curated interactions for CHI3L2 Gene
Drugs & Compounds for CHI3L2 Gene
Drug Products
- G Biosciences Human Chitinase-3-like protein 2/CHI3L2, Lyophilized
Transcripts for CHI3L2 Gene
mRNA/cDNA for CHI3L2 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000445067 2169 nts (view in UCSC)
- ENST00000528451 946 nts (view in UCSC)
- ENST00000486561 914 nts (view in UCSC)
- ENST00000369744 1489 nts (view in UCSC)
- ENST00000474304 600 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CHI3L2 - Select products 50% OFF >
- * CHI3L2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
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-
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miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for CHI3L2 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for CHI3L2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHI3L2
Relevant External Links for CHI3L2 Gene
- GeneLoc Exon Structure for
- CHI3L2
Expression for CHI3L2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
- Bone (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Cartilage (Muscoskeletal System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CHI3L2 Gene
This gene is overexpressed in Minor Salivary Gland (x8.2) and Lung (x4.4).
This gene is overexpressed in Salivary gland (44.8), Synovial fluid (8.0), and Breast (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHI3L2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHI3L2
SOURCE GeneReport for Unigene cluster for CHI3L2 Gene:
Hs.514840mRNA Expression by UniProt/SwissProt for CHI3L2 Gene:
Q15782-CH3L2_HUMAN
Tissue specificity:
Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
Evidence on tissue expression from TISSUES for CHI3L2 Gene
- Nervous system(4.5)
- Blood(2.8)
- Lung(2.8)
- Intestine(2.6)
- Lymph node(2.4)
- Spleen(2.2)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for CHI3L2
-
OriGene qPCR primer pairs and template standards for CHI3L2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHI3L2 Gene
Orthologs for CHI3L2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CHI3L2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CHI3L2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | CHI3L2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG2989 32 |
|
|
|
| CG9357 32 |
|
|
|||
| CG10531 32 |
|
|
|||
| Cht3 32 |
|
|
|||
| Cht1 32 |
|
|
|||
| Cht2 32 |
|
|
|||
| CG3044 32 |
|
|
|||
| Idgf4 32 |
|
|
|||
| Chit 32 |
|
|
|||
| Cht7 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | cht-1 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CTS2 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8046 31 |
|
OneToMany |
- Species where no ortholog for CHI3L2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for CHI3L2 Gene
- ENSEMBL:
- Gene Tree for CHI3L2 (if available)
- TreeFam:
- Gene Tree for CHI3L2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CHI3L2: view image
Paralogs for CHI3L2 Gene
(5) SIMAP similar genes for CHI3L2 Gene using alignment to 10 proteins:
- CH3L2_HUMAN
- E9PII8_HUMAN
- E9PIX1_HUMAN
- E9PP75_HUMAN
- E9PPX4_HUMAN
- E9PR52_HUMAN
- E9PRL9_HUMAN
- H0YD88_HUMAN
- H0YE91_HUMAN
- H0YEJ1_HUMAN
Pseudogenes.org Pseudogenes for CHI3L2 Gene
Variants for CHI3L2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHI3L2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 723214 | Benign: not provided | 111,242,359(+) | C/T | SYNONYMOUS_VARIANT | |
| 725533 | Likely Benign: not provided | 111,230,935(+) | C/T | SYNONYMOUS_VARIANT | |
| 769524 | Benign: not provided | 111,235,708(+) | G/A | MISSENSE_VARIANT | |
| rs13721 | Benign: not specified. - | 111,241,360(+) | C/Tp.Arg318Trp | MISSENSE_VARIANT | |
| rs1553176789 | Uncertain Significance: not provided | 111,242,348(+) | GC/G | FRAMESHIFT_VARIANT |
Residual Variation Intolerance Score:
89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.67;
72.88% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHI3L2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHI3L2 Gene
Disorders for CHI3L2 Gene
Additional Disease Information for CHI3L2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for CHI3L2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHI3L2 Gene
Publications for CHI3L2 Gene
- Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. (PMID: 8702629) Hu B … Price PA (The Journal of biological chemistry 1996) 2 3 4 23
- Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties. (PMID: 22742450) Schimpl M … van Aalten DM (The Biochemical journal 2012) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. (PMID: 12435396) Steck E … Richter W (Biochemical and biophysical research communications 2002) 3 23
- M2 Macrophage Marker Chitinase 3-Like 2 (CHI3L2) Associates With Progression of Conventional Renal Cell Carcinoma. (PMID: 31810965) Pusztai C … Kovacs G (Anticancer research 2019) 3
ExternalLinks
Products for CHI3L2 Gene
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- antibodies-online: Show 16 available CHI3L2 Antibodies ranked by validation data
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Sources for CHI3L2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
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