This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009] See more...

Aliases for CHGB Gene

Aliases for CHGB Gene

  • Chromogranin B 2 3 5
  • Secretogranin I 3 4
  • Secretogranin-1 3 4
  • Secretogranin B 2 3
  • SCG1 3 4
  • CgB 3 4
  • SgI 3 4
  • Secretogranin 1 2
  • Chromogranin-B 4

External Ids for CHGB Gene

Previous HGNC Symbols for CHGB Gene

  • SCG1

Previous GeneCards Identifiers for CHGB Gene

  • GC20P005880
  • GC20P005840
  • GC20P005887
  • GC20P005848
  • GC20P005891

Summaries for CHGB Gene

Entrez Gene Summary for CHGB Gene

  • This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

GeneCards Summary for CHGB Gene

CHGB (Chromogranin B) is a Protein Coding gene. Diseases associated with CHGB include Pheochromocytoma and Neuroendocrine Tumor. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CHGA.

UniProtKB/Swiss-Prot Summary for CHGB Gene

  • Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

Gene Wiki entry for CHGB Gene

Additional gene information for CHGB Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHGB Gene

Genomics for CHGB Gene

GeneHancer (GH) Regulatory Elements for CHGB Gene

Promoters and enhancers for CHGB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J005911 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 505.3 +0.5 450 1.6 EP300 HNRNPK CTCF TCF12 MYC PHF8 JUND ZIC2 REST POLR2A CHGB MCM8 lnc-TRMT6-1
GH20J005844 Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.3 -66.3 -66287 4.9 ZBTB40 EP300 ZSCAN5C TCF12 SP1 ZNF639 ZNF10 ZIC2 TRIM28 RFX1 CHGB RNU1-55P MCM8 TRMT6 HSALNG0128433 RF00003-045 SHLD1
GH20J005820 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 -88.9 -88940 4 POLR2G JUND ZIC2 KDM6A TCF7 ZBTB25 TGIF2 SKI TEAD1 ZBTB26 ENSG00000235820 RPS18P1 CHGB RNU1-55P MCM8 TRMT6 CDS2 HSALNG0128433 RF00003-045 SHLD1
GH20J005778 Enhancer 1.4 Ensembl ENCODE dbSUPER 10.3 -126.6 -126616 11.8 EP300 CTCF TCF12 NCOR1 FOS PHB2 KDM6A TCF7 FOXA1 AFF1 GPCPD1 ENSG00000235820 RPS18P1 CRLS1 MCM8 TRMT6 CHGB LINC00654 HSALNG0128433 piR-60140-014
GH20J005861 Enhancer 0.8 ENCODE dbSUPER 17.2 -47.2 -47213 4.9 FOS REST POLR2A RFX1 MXI1 GATA3 SPI1 JUND CEBPG RCOR1 CHGB RNU1-55P MCM8 TRMT6 SHLD1 RF00003-045 HSALNG0128433
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHGB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHGB

Top Transcription factor binding sites by QIAGEN in the CHGB gene promoter:
  • AML1a
  • AP-1
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alpha isoform 4
  • AP-2alphaA
  • NRSF form 1
  • NRSF form 2
  • RSRFC4

Genomic Locations for CHGB Gene

Genomic Locations for CHGB Gene
chr20:5,911,328-5,925,361
(GRCh38/hg38)
Size:
14,034 bases
Orientation:
Plus strand
chr20:5,891,974-5,906,007
(GRCh37/hg19)
Size:
14,034 bases
Orientation:
Plus strand

Genomic View for CHGB Gene

Genes around CHGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHGB Gene

Proteins for CHGB Gene

  • Protein details for CHGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05060-SCG1_HUMAN
    Recommended name:
    Secretogranin-1
    Protein Accession:
    P05060
    Secondary Accessions:
    • A8K021
    • Q59EU9
    • Q6IBS6
    • Q9BQV6
    • Q9UC25
    • Q9UJA6

    Protein attributes for CHGB Gene

    Size:
    677 amino acids
    Molecular mass:
    78276 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92949.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for CHGB Gene

Post-translational modifications for CHGB Gene

  • Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
  • O-glycosylated.
  • Glycosylation at Asn315
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for CHGB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHGB Gene

Domains & Families for CHGB Gene

Gene Families for CHGB Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CHGB Gene

Blocks:
  • Chromogranin/secretogranin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHGB Gene

GenScript: Design optimal peptide antigens:
  • Secretogranin I (SCG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P05060

UniProtKB/Swiss-Prot:

SCG1_HUMAN :
  • Belongs to the chromogranin/secretogranin protein family.
Family:
  • Belongs to the chromogranin/secretogranin protein family.
genes like me logo Genes that share domains with CHGB: view

Function for CHGB Gene

Molecular function for CHGB Gene

UniProtKB/Swiss-Prot Function:
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
GENATLAS Biochemistry:
chromogranin B (catecholamine and norepenephrine secretory protein)

Phenotypes From GWAS Catalog for CHGB Gene

Gene Ontology (GO) - Molecular Function for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 3608978
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with CHGB: view
genes like me logo Genes that share phenotypes with CHGB: view

Animal Models for CHGB Gene

MGI Knock Outs for CHGB:
  • Chgb Chgb<tm1Ribo>

Animal Model Products

  • Taconic Biosciences Mouse Models for CHGB

CRISPR Products

miRNA for CHGB Gene

miRTarBase miRNAs that target CHGB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHGB Gene

Localization for CHGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHGB Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHGB gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
plasma membrane 2
cytoskeleton 2
nucleus 2
golgi apparatus 2
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0030141 secretory granule IBA,IEA 21873635
genes like me logo Genes that share ontologies with CHGB: view

Pathways & Interactions for CHGB Gene

PathCards logo

SuperPathways for CHGB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with CHGB: view

No data available for Pathways by source and SIGNOR curated interactions for CHGB Gene

Drugs & Compounds for CHGB Gene

(11) Drugs for CHGB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for CHGB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHGB: view

Transcripts for CHGB Gene

mRNA/cDNA for CHGB Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHGB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6:
SP7: - - - - -

Relevant External Links for CHGB Gene

GeneLoc Exon Structure for
CHGB

Expression for CHGB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHGB Gene

This gene is overexpressed in Pituitary (x18.6), Brain - Cerebellar Hemisphere (x9.1), Brain - Cerebellum (x6.1), and Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CHGB Gene

This gene is overexpressed in Cerebrospinal fluid (35.5) and Adrenal (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHGB Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHGB

SOURCE GeneReport for Unigene cluster for CHGB Gene:

Hs.516874

mRNA Expression by UniProt/SwissProt for CHGB Gene:

P05060-SCG1_HUMAN
Tissue specificity: Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.

Evidence on tissue expression from TISSUES for CHGB Gene

  • Nervous system(5)
  • Adrenal gland(4.8)
  • Pancreas(4.7)
  • Lung(4.2)
  • Liver(4)
  • Stomach(2.5)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CHGB: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHGB Gene

Orthologs for CHGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHGB 31 30
  • 99.11 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CHGB 31 30
  • 83.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CHGB 31 30
  • 78.6 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Chgb 17 31 30
  • 76.28 (n)
rat
(Rattus norvegicus)
Mammalia Chgb 30
  • 76.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHGB 31
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHGB 31
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHGB 31 30
  • 53.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHGB 31
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19044 30
Species where no ortholog for CHGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CHGB Gene

ENSEMBL:
Gene Tree for CHGB (if available)
TreeFam:
Gene Tree for CHGB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHGB: view image

Paralogs for CHGB Gene

Paralogs for CHGB Gene

genes like me logo Genes that share paralogs with CHGB: view

Variants for CHGB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHGB Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
712867 Benign: not provided 5,923,286(+) G/T MISSENSE_VARIANT
744891 Benign: not provided 5,923,000(+) G/A MISSENSE_VARIANT
781543 Benign: not provided 5,924,109(+) T/C INTRON_VARIANT
rs193921088 Uncertain Significance: Malignant tumor of prostate 5,923,452(+) A/C MISSENSE_VARIANT
rs236150 - p.Lys117Asn

Additional dbSNP identifiers (rs#s) for CHGB Gene

Structural Variations from Database of Genomic Variants (DGV) for CHGB Gene

Variant ID Type Subtype PubMed ID
nsv525940 CNV loss 19592680
nsv833905 CNV gain 17160897

Variation tolerance for CHGB Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHGB Gene

Human Gene Mutation Database (HGMD)
CHGB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHGB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHGB Gene

Disorders for CHGB Gene

MalaCards: The human disease database

(17) MalaCards diseases for CHGB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pcc
neuroendocrine tumor
  • neuroendocrine neoplasm
glucagonoma
  • glucagonoma syndrome
collagenous colitis
  • microscopic colitis, collagenous type
paraganglioma
  • chemodectoma
- elite association - COSMIC cancer census association via MalaCards
Search CHGB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHGB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CHGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHGB Gene

Publications for CHGB Gene

  1. Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. (PMID: 20007371) Gros-Louis F … Julien JP (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23 41 54
  2. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PMID: 18180394) Fung MM … O'Connor DT (Circulation 2008) 3 23 41 54
  3. Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population. (PMID: 15219467) Iijima Y … Arinami T (Biological psychiatry 2004) 3 23 41 54
  4. Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing. (PMID: 1882087) Gill BM … O'Connor DT (Regulatory peptides 1991) 3 4 23 54
  5. The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region. (PMID: 3608978) Benedum UM … Huttner WB (The EMBO journal 1987) 2 3 4 54

Products for CHGB Gene

Sources for CHGB Gene