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Aliases for CHGB Gene

Aliases for CHGB Gene

  • Chromogranin B 2 3 5
  • Secretogranin I 3 4
  • Secretogranin B 2 3
  • SCG1 3 4
  • CgB 3 4
  • SgI 3 4
  • Secretogranin-1 3
  • Secretogranin 1 2
  • Chromogranin-B 4

External Ids for CHGB Gene

Previous HGNC Symbols for CHGB Gene

  • SCG1

Previous GeneCards Identifiers for CHGB Gene

  • GC20P005880
  • GC20P005840
  • GC20P005887
  • GC20P005848

Summaries for CHGB Gene

Entrez Gene Summary for CHGB Gene

  • This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

GeneCards Summary for CHGB Gene

CHGB (Chromogranin B) is a Protein Coding gene. Diseases associated with CHGB include Glucagonoma and Pheochromocytoma. Gene Ontology (GO) annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for CHGB Gene

  • Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

Gene Wiki entry for CHGB Gene

Additional gene information for CHGB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHGB Gene

Genomics for CHGB Gene

GeneHancer (GH) Regulatory Elements for CHGB Gene

Promoters and enhancers for CHGB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J005911 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.4 +0.4 351 1.3 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 SP3 CHGB MCM8 KANK1P1
GH20J005861 Enhancer 1 Ensembl ENCODE dbSUPER 17.2 -47.2 -47213 4.9 SOX13 RFX1 JUN CEBPG MNT JUND POLR2A RFX3 RCOR1 FOS CHGB RNU1-55P MCM8 TRMT6 SHLD1 GC20P005890
GH20J005845 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -65.0 -65038 2.4 FOXA2 INSM2 KLF17 MZF1 FEZF1 BMI1 ZEB1 ZNF213 ZNF366 SCRT2 CHGB RNU1-55P TRMT6 MCM8 GC20P005890 SHLD1
GH20J005843 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -67.3 -67262 1.4 PKNOX1 FOXA2 SIN3A IRF4 GLIS2 ATF7 FOS RUNX3 SP3 JUNB RNU1-55P CHGB TRMT6 MCM8 GC20P005890 SHLD1
GH20J005834 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -75.4 -75398 3 ELF3 SOX13 FOXA2 CEBPG ZNF384 BMI1 RARA POLR2A FOSL2 NR2F6 RNU1-55P CHGB MCM8 TRMT6 GC20P005890 SHLD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHGB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHGB gene promoter:

Genomic Locations for CHGB Gene

Genomic Locations for CHGB Gene
14,034 bases
Plus strand

Genomic View for CHGB Gene

Genes around CHGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHGB Gene

Proteins for CHGB Gene

  • Protein details for CHGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K021
    • Q59EU9
    • Q6IBS6
    • Q9BQV6
    • Q9UC25
    • Q9UJA6

    Protein attributes for CHGB Gene

    677 amino acids
    Molecular mass:
    78276 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CHGB Gene

Post-translational modifications for CHGB Gene

  • Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
  • O-glycosylated.
  • Glycosylation at Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for CHGB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CHGB (Chromogranin B)
  • Boster Bio Antibodies for CHGB
  • Santa Cruz Biotechnology (SCBT) Antibodies for CHGB

No data available for DME Specific Peptides for CHGB Gene

Domains & Families for CHGB Gene

Gene Families for CHGB Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CHGB Gene

Suggested Antigen Peptide Sequences for CHGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the chromogranin/secretogranin protein family.
  • Belongs to the chromogranin/secretogranin protein family.
genes like me logo Genes that share domains with CHGB: view

Function for CHGB Gene

Molecular function for CHGB Gene

UniProtKB/Swiss-Prot Function:
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
GENATLAS Biochemistry:
chromogranin B (catecholamine and norepenephrine secretory protein)

Gene Ontology (GO) - Molecular Function for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 3608978
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with CHGB: view
genes like me logo Genes that share phenotypes with CHGB: view

Animal Models for CHGB Gene

MGI Knock Outs for CHGB:
  • Chgb Chgb<tm1Ribo>

Animal Model Products

  • Taconic Biosciences Mouse Models for CHGB

miRNA for CHGB Gene

miRTarBase miRNAs that target CHGB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHGB Gene

Localization for CHGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHGB Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHGB gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 2
plasma membrane 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with CHGB: view

Pathways & Interactions for CHGB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010469 regulation of signaling receptor activity IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with CHGB: view

No data available for Pathways by source and SIGNOR curated interactions for CHGB Gene

Drugs & Compounds for CHGB Gene

(11) Drugs for CHGB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for CHGB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHGB: view

Transcripts for CHGB Gene

mRNA/cDNA for CHGB Gene

(377) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHGB Gene

Chromogranin B (secretogranin 1):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHGB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - -
SP7: - - - - -

Relevant External Links for CHGB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHGB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHGB Gene

This gene is overexpressed in Pituitary (x18.6), Brain - Cerebellar Hemisphere (x9.1), Brain - Cerebellum (x6.1), and Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CHGB Gene

This gene is overexpressed in Cerebrospinal fluid (35.5) and Adrenal (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHGB Gene

NURSA nuclear receptor signaling pathways regulating expression of CHGB Gene:


SOURCE GeneReport for Unigene cluster for CHGB Gene:


mRNA Expression by UniProt/SwissProt for CHGB Gene:

Tissue specificity: Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.

Evidence on tissue expression from TISSUES for CHGB Gene

  • Nervous system(5)
  • Adrenal gland(4.8)
  • Pancreas(4.7)
  • Lung(4.2)
  • Liver(4)
  • Stomach(2.5)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CHGB: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHGB Gene

Orthologs for CHGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHGB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHGB 34 33
  • 99.11 (n)
(Canis familiaris)
Mammalia CHGB 34 33
  • 83.74 (n)
(Bos Taurus)
Mammalia CHGB 34 33
  • 78.6 (n)
(Mus musculus)
Mammalia Chgb 16 34 33
  • 76.28 (n)
(Rattus norvegicus)
Mammalia Chgb 33
  • 76.21 (n)
(Ornithorhynchus anatinus)
Mammalia CHGB 34
  • 44 (a)
(Monodelphis domestica)
Mammalia CHGB 34
  • 38 (a)
(Gallus gallus)
Aves CHGB 34 33
  • 53.66 (n)
(Anolis carolinensis)
Reptilia CHGB 34
  • 22 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19044 33
Species where no ortholog for CHGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CHGB Gene

Gene Tree for CHGB (if available)
Gene Tree for CHGB (if available)
Evolutionary constrained regions (ECRs) for CHGB: view image

Paralogs for CHGB Gene

No data available for Paralogs for CHGB Gene

Variants for CHGB Gene

Sequence variations from dbSNP and Humsavar for CHGB Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs193921088 uncertain-significance, Malignant tumor of prostate 5,923,452(+) A/C coding_sequence_variant, missense_variant
rs1000203594 -- 5,909,921(+) C/A upstream_transcript_variant
rs1000245093 -- 5,915,011(+) T/C intron_variant
rs1000255913 -- 5,910,238(+) A/G upstream_transcript_variant
rs1000354322 -- 5,920,751(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHGB Gene

Variant ID Type Subtype PubMed ID
nsv525940 CNV loss 19592680
nsv833905 CNV gain 17160897

Variation tolerance for CHGB Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHGB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHGB Gene

Disorders for CHGB Gene

MalaCards: The human disease database

(8) MalaCards diseases for CHGB Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • glucagonoma syndrome
  • pheochromocytoma, susceptibility to
mixed ductal-endocrine carcinoma
collagenous colitis
  • microscopic colitis, collagenous type
neuroendocrine tumor
  • neuroendocrine neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CHGB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHGB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CHGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHGB Gene

Publications for CHGB Gene

  1. Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. (PMID: 20007371) Gros-Louis F … Julien JP (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 44 58
  2. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PMID: 18180394) Fung MM … O'Connor DT (Circulation 2008) 3 22 44 58
  3. Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population. (PMID: 15219467) Iijima Y … Arinami T (Biological psychiatry 2004) 3 22 44 58
  4. Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing. (PMID: 1882087) Gill BM … O'Connor DT (Regulatory peptides 1991) 3 4 22 58
  5. The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region. (PMID: 3608978) Benedum UM … Huttner WB (The EMBO journal 1987) 2 3 4 58

Products for CHGB Gene

Sources for CHGB Gene

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