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Aliases for CHERP Gene

Aliases for CHERP Gene

  • Calcium Homeostasis Endoplasmic Reticulum Protein 2 3 3 5
  • ERPROT 213-21 3 4
  • SCAF6 3 4
  • SR-Related CTD Associated Factor 6 3
  • SR-Related CTD-Associated Factor 6 4
  • Protein With Polyglutamine Repeat 3
  • ERPROT213-21 3
  • DAN16 3
  • DAN26 4
  • SRA1 3

External Ids for CHERP Gene

Previous GeneCards Identifiers for CHERP Gene

  • GC19M017122
  • GC19M017020
  • GC19M016473
  • GC19M016629
  • GC19M016197

Summaries for CHERP Gene

GeneCards Summary for CHERP Gene

CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein) is a Protein Coding gene. Diseases associated with CHERP include Spinocerebellar Ataxia 1 and Autosomal Dominant Cerebellar Ataxia. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for CHERP Gene

  • Involved in calcium homeostasis, growth and proliferation.

Additional gene information for CHERP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHERP Gene

Genomics for CHERP Gene

GeneHancer (GH) Regulatory Elements for CHERP Gene

Promoters and enhancers for CHERP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J016540 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 681.8 +0.2 188 2.9 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 CHERP ENSG00000269399 GC19P020598 ENSG00000269578 C19orf44 SIN3B ENSG00000268743 HAUS8 ENSG00000269439 RAB8A
GH19J017336 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 170.1 -794.8 -794826 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTPBP3 ANO8 CHERP ENSG00000269578 IQCN ENSG00000268743 COLGALT1 C19orf44 HAUS8 SIN3B
GH19J016532 Promoter 0.5 EPDnew 650.4 +10.4 10413 0.1 CHERP SLC35E1 C19orf44 ENSG00000141979 EPS15L1 CPAMD8 RN7SL146P GC19M016221
GH19J016530 Promoter 0.5 EPDnew 650.4 +11.8 11814 0.1 CHERP SLC35E1 C19orf44 ENSG00000141979 EPS15L1 CPAMD8 RN7SL146P GC19M016221
GH19J016063 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 105.4 +469.6 469617 18.7 CLOCK FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 MCM3 SP3 TPM4 AKAP8 CHERP ENSG00000269578 ENSG00000268087 ENSG00000267904 BRD4 C19orf44 ENSG00000268743 SIN3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHERP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHERP gene promoter:

Genomic Locations for CHERP Gene

Genomic Locations for CHERP Gene
24,642 bases
Minus strand

Genomic View for CHERP Gene

Genes around CHERP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHERP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHERP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHERP Gene

Proteins for CHERP Gene

  • Protein details for CHERP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium homeostasis endoplasmic reticulum protein
    Protein Accession:
    Secondary Accessions:
    • O00302
    • Q4G0Y5
    • Q8WU30
    • Q99492

    Protein attributes for CHERP Gene

    916 amino acids
    Molecular mass:
    103702 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB53327.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH21294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA69591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA69591.1; Type=Frameshift; Positions=450; Evidence={ECO:0000305};

neXtProt entry for CHERP Gene

Post-translational modifications for CHERP Gene

  • Ubiquitination at posLast=177177
  • Modification sites at PhosphoSitePlus

Other Protein References for CHERP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHERP Gene

Domains & Families for CHERP Gene

Gene Families for CHERP Gene

Suggested Antigen Peptide Sequences for CHERP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHERP: view

No data available for UniProtKB/Swiss-Prot for CHERP Gene

Function for CHERP Gene

Molecular function for CHERP Gene

UniProtKB/Swiss-Prot Function:
Involved in calcium homeostasis, growth and proliferation.

Phenotypes From GWAS Catalog for CHERP Gene

Gene Ontology (GO) - Molecular Function for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0005515 protein binding IPI 22365833
GO:0044325 ion channel binding IPI 21454501
genes like me logo Genes that share ontologies with CHERP: view
genes like me logo Genes that share phenotypes with CHERP: view

Animal Model Products

miRNA for CHERP Gene

miRTarBase miRNAs that target CHERP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHERP Gene

Localization for CHERP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHERP Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. {ECO:0000269 PubMed:10794731, ECO:0000269 PubMed:12656674, ECO:0000269 PubMed:8010949}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHERP gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 10794731
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane HDA 19946888
GO:0033017 sarcoplasmic reticulum membrane IEA,ISS --
genes like me logo Genes that share ontologies with CHERP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHERP Gene

Pathways & Interactions for CHERP Gene

genes like me logo Genes that share pathways with CHERP: view

Pathways by source for CHERP Gene

Gene Ontology (GO) - Biological Process for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing IEA --
GO:0006874 cellular calcium ion homeostasis IDA 10794731
GO:0007399 nervous system development TAS 8896557
GO:0008285 negative regulation of cell proliferation IDA 10794731
genes like me logo Genes that share ontologies with CHERP: view

No data available for SIGNOR curated interactions for CHERP Gene

Drugs & Compounds for CHERP Gene

(3) Drugs for CHERP Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CHERP: view

Transcripts for CHERP Gene

mRNA/cDNA for CHERP Gene

Unigene Clusters for CHERP Gene

Calcium homeostasis endoplasmic reticulum protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHERP Gene

No ASD Table

Relevant External Links for CHERP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHERP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHERP Gene

Protein differential expression in normal tissues from HIPED for CHERP Gene

This gene is overexpressed in Lymph node (8.6) and Fetal ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHERP Gene

Protein tissue co-expression partners for CHERP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHERP Gene:


SOURCE GeneReport for Unigene cluster for CHERP Gene:


mRNA Expression by UniProt/SwissProt for CHERP Gene:

Tissue specificity: Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and in cultured HEL and Dami cells.

Evidence on tissue expression from TISSUES for CHERP Gene

  • Nervous system(4.2)
  • Lung(3.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CHERP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHERP Gene

Orthologs for CHERP Gene

This gene was present in the common ancestor of animals.

Orthologs for CHERP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHERP 34 33
  • 95.3 (n)
(Ornithorhynchus anatinus)
Mammalia CHERP 34
  • 95 (a)
(Bos Taurus)
Mammalia CHERP 34 33
  • 91.08 (n)
(Monodelphis domestica)
Mammalia CHERP 34
  • 91 (a)
(Canis familiaris)
Mammalia CHERP 34 33
  • 90.28 (n)
(Rattus norvegicus)
Mammalia Cherp 33
  • 86.29 (n)
(Mus musculus)
Mammalia Cherp 16 34 33
  • 85.12 (n)
(Gallus gallus)
Aves CHERP 34 33
  • 74.75 (n)
(Anolis carolinensis)
Reptilia CHERP 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cherp 33
  • 72.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia cherp-prov 33
(Danio rerio)
Actinopterygii cherp 34 33
  • 72.76 (n)
iktdsubc_2h12 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9770 33
fruit fly
(Drosophila melanogaster)
Insecta scaf6 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea tag-65 34
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5488 34
  • 39 (a)
Cin.2440 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2440 33
Species where no ortholog for CHERP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHERP Gene

Gene Tree for CHERP (if available)
Gene Tree for CHERP (if available)
Evolutionary constrained regions (ECRs) for CHERP: view image

Paralogs for CHERP Gene

No data available for Paralogs for CHERP Gene

Variants for CHERP Gene

Sequence variations from dbSNP and Humsavar for CHERP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000003678 -- 16,543,754(-) G/C upstream_transcript_variant
rs1000046955 -- 16,530,095(-) G/C intron_variant
rs1000175285 -- 16,533,501(-) T/C intron_variant
rs1000190575 -- 16,534,062(-) T/C intron_variant
rs1000211722 -- 16,539,324(-) T/A intron_variant

Variation tolerance for CHERP Gene

Residual Variation Intolerance Score: 4.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHERP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CHERP Gene

Disorders for CHERP Gene

MalaCards: The human disease database

(2) MalaCards diseases for CHERP Gene - From: Novoseek

Disorder Aliases PubMed IDs
spinocerebellar ataxia 1
  • sca1
autosomal dominant cerebellar ataxia
  • spinocerebellar ataxia
- elite association - COSMIC cancer census association via MalaCards
Search CHERP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHERP

genes like me logo Genes that share disorders with CHERP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHERP Gene

Publications for CHERP Gene

  1. Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation. (PMID: 10794731) Laplante JM … Feinstein MB (The Biochemical journal 2000) 2 3 4 22 58
  2. Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes. (PMID: 12656674) O'Rourke FA … Feinstein MB (The Biochemical journal 2003) 3 4 22 58
  3. Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. (PMID: 8896557) Imbert G … Brice A (Nature genetics 1996) 2 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for CHERP Gene

Sources for CHERP Gene

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