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Aliases for CHD4 Gene

Aliases for CHD4 Gene

  • Chromodomain Helicase DNA Binding Protein 4 2 3 5
  • Mi-2 Autoantigen 218 KDa Protein 3 4
  • ATP-Dependent Helicase CHD4 3 4
  • Mi2-BETA 3 4
  • CHD-4 3 4
  • Chromodomain-Helicase-DNA-Binding Protein 4 3
  • EC 3.6.4.12 4
  • EC 3.6.1 56
  • SIHIWES 3
  • Mi-2b 3

External Ids for CHD4 Gene

Previous GeneCards Identifiers for CHD4 Gene

  • GC12M006534
  • GC12M006653
  • GC12M006558
  • GC12M006549
  • GC12M006679
  • GC12M006533

Summaries for CHD4 Gene

Entrez Gene Summary for CHD4 Gene

  • The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for CHD4 Gene

CHD4 (Chromodomain Helicase DNA Binding Protein 4) is a Protein Coding gene. Diseases associated with CHD4 include Sifrim-Hitz-Weiss Syndrome and Dermatomyositis. Among its related pathways are PI3K-Akt signaling pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include hydrolase activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is CHD5.

UniProtKB/Swiss-Prot for CHD4 Gene

  • Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

Gene Wiki entry for CHD4 Gene

Additional gene information for CHD4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD4 Gene

Genomics for CHD4 Gene

GeneHancer (GH) Regulatory Elements for CHD4 Gene

Promoters and enhancers for CHD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I006602 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 588.8 +1.7 1748 7.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CHD4 ZNF384 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 ING4 SPSB2 EMG1 SCARNA12
GH12I006940 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 77.4 -346.2 -346182 25.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PTPN6 C12orf57 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 SPSB2 SCARNA12 ENSG00000256967 NCAPD2
GH12I006530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 58.1 +70.4 70380 12.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GAPDH ENSG00000269968 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 NCAPD2 NOP2 SPSB2 ENSG00000256967
GH12I006662 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 52.7 -55.8 -55751 2.2 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 ENSG00000219410 ING4 ZNF384 CHD4 ENSG00000247853 EMG1 NCAPD2 SPSB2 SCARNA12 NOP2
GH12I006459 Enhancer 1.3 Ensembl ENCODE dbSUPER 81.9 +145.3 145332 6.3 HDGF PKNOX1 ZFP64 BMI1 IRF4 ZNF213 ZNF207 ZNF143 ATF7 ETV6 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 TAPBPL MRPL51 NOP2 SCARNA12 VAMP1 P3H3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHD4 gene promoter:

Genomic Locations for CHD4 Gene

Genomic Locations for CHD4 Gene
chr12:6,570,082-6,607,476
(GRCh38/hg38)
Size:
37,395 bases
Orientation:
Minus strand
chr12:6,679,248-6,716,642
(GRCh37/hg19)

Genomic View for CHD4 Gene

Genes around CHD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHD4 Gene

Proteins for CHD4 Gene

  • Protein details for CHD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14839-CHD4_HUMAN
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 4
    Protein Accession:
    Q14839
    Secondary Accessions:
    • Q8IXZ5

    Protein attributes for CHD4 Gene

    Size:
    1912 amino acids
    Molecular mass:
    218005 Da
    Quaternary structure:
    • Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (By similarity). Interacts directly with IKFZ1 in the NuRD complex. Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex (PubMed:9804427, PubMed:10204490, PubMed:15454082). Part of a complex containing ATR and HDAC2 (PubMed:10545197). Interacts with TRIM27 (PubMed:14530259). Interacts with ZGPAT; the interaction is direct (PubMed:19644445). Interacts with BCL6 (PubMed:15454082). Interacts with BRD4 (PubMed:21555454). Interacts with PCNT (PubMed:17626165). Interacts with SETX (PubMed:23149945). Interacts with HDAC1 (PubMed:27616479).
    Miscellaneous:
    • One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.

    Three dimensional structures from OCA and Proteopedia for CHD4 Gene

    Alternative splice isoforms for CHD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHD4 Gene

Selected DME Specific Peptides for CHD4 Gene

Q14839:
  • AGNKPANAVLHKVL
  • RWQDIQND
  • DEMGLGKT
  • DEAHRLK
  • TGTPLQN
  • VLLTSYELI
  • KMMLTHLVVRPG
  • ETFADGVPREGLSRQ
  • GHRVLIF
  • NQSKFFR
  • FLLSTRA
  • YKYERIDGGITG
  • NEYLSSFKVA
  • AGGLGINL
  • FLYSLYKEGH
  • RVLIFSQM
  • PEGKWSCPHCE
  • RAHRIGQ
  • DSDWNPH
  • GLGKTVQ
  • LSTRAGGLG

Post-translational modifications for CHD4 Gene

  • Ubiquitination at posLast=504504, posLast=10571057, posLast=10921092, posLast=18371837, posLast=18521852, Lys1855, and posLast=18651865

Domains & Families for CHD4 Gene

Gene Families for CHD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CHD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14839

UniProtKB/Swiss-Prot:

CHD4_HUMAN :
  • Belongs to the SNF2/RAD54 helicase family.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with CHD4: view

Function for CHD4 Gene

Molecular function for CHD4 Gene

GENATLAS Biochemistry:
DNA binding protein with two chromatin organization (chromo) domains,and a helicase domain,4,component of the chromatin remodeling complex
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

Enzyme Numbers (IUBMB) for CHD4 Gene

Phenotypes From GWAS Catalog for CHD4 Gene

Gene Ontology (GO) - Molecular Function for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000978 contributes_to RNA polymerase II proximal promoter sequence-specific DNA binding HDA,IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding HDA,IDA 16217013
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
GO:0003677 DNA binding TAS 9326634
genes like me logo Genes that share ontologies with CHD4: view
genes like me logo Genes that share phenotypes with CHD4: view

Human Phenotype Ontology for CHD4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CHD4 Gene

MGI Knock Outs for CHD4:

miRNA for CHD4 Gene

miRTarBase miRNAs that target CHD4

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CHD4 Gene

Localization for CHD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHD4 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase. {ECO:0000250 UniProtKB:Q6PDQ2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHD4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin HDA,IDA 16217013
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 17626165
GO:0005813 centrosome IDA 17626165
genes like me logo Genes that share ontologies with CHD4: view

Pathways & Interactions for CHD4 Gene

genes like me logo Genes that share pathways with CHD4: view

Pathways by source for CHD4 Gene

Gene Ontology (GO) - Biological Process for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9326634
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with CHD4: view

No data available for SIGNOR curated interactions for CHD4 Gene

Drugs & Compounds for CHD4 Gene

(3) Drugs for CHD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for CHD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CHD4: view

Transcripts for CHD4 Gene

Unigene Clusters for CHD4 Gene

Chromodomain helicase DNA binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a ·
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SP29: - -
SP30: - - -
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ExUns: 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28a ·
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ExUns: 28b ^ 29a · 29b · 29c ^ 30a · 30b · 30c ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b · 33c · 33d ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38a · 38b · 38c ^
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SP19: - - - -
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ExUns: 39a · 39b ^ 40 ^ 41 ^ 42a · 42b ^ 43 ^ 44a ·
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Relevant External Links for CHD4 Gene

GeneLoc Exon Structure for
CHD4
ECgene alternative splicing isoforms for
CHD4

Expression for CHD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHD4 Gene

Protein differential expression in normal tissues from HIPED for CHD4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5) and Lymph node (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHD4 Gene



Protein tissue co-expression partners for CHD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHD4 Gene:

CHD4

SOURCE GeneReport for Unigene cluster for CHD4 Gene:

Hs.162233

Evidence on tissue expression from TISSUES for CHD4 Gene

  • Skin(4.6)
  • Liver(4.5)
  • Nervous system(4.4)
  • Lung(3.7)
  • Eye(3.3)
  • Intestine(3.3)
  • Pancreas(2.9)
  • Heart(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with CHD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHD4 Gene

Orthologs for CHD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHD4 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHD4 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHD4 33 34
  • 94.07 (n)
cow
(Bos Taurus)
Mammalia CHD4 33 34
  • 92.14 (n)
rat
(Rattus norvegicus)
Mammalia Chd4 33
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Chd4 33 16 34
  • 91.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHD4 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHD4 33 34
  • 78.84 (n)
lizard
(Anolis carolinensis)
Reptilia CHD4 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chd4 33
  • 75.12 (n)
Str.16957 33
African clawed frog
(Xenopus laevis)
Amphibia b230399n07-prov 33
zebrafish
(Danio rerio)
Actinopterygii chd4b 34
  • 76 (a)
OneToMany
chd4a 33 34
  • 73.18 (n)
Dr.27188 33