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Aliases for CHD4 Gene

Aliases for CHD4 Gene

  • Chromodomain Helicase DNA Binding Protein 4 2 3 5
  • Mi-2 Autoantigen 218 KDa Protein 3 4
  • ATP-Dependent Helicase CHD4 3 4
  • CHD-4 3 4
  • Chromodomain-Helicase-DNA-Binding Protein 4 3
  • EC 3.6.4.12 4
  • Mi2-BETA 3
  • Mi2-Beta 4
  • SIHIWES 3
  • Mi-2b 3

External Ids for CHD4 Gene

Previous GeneCards Identifiers for CHD4 Gene

  • GC12M006534
  • GC12M006653
  • GC12M006558
  • GC12M006549
  • GC12M006679
  • GC12M006533

Summaries for CHD4 Gene

Entrez Gene Summary for CHD4 Gene

  • The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for CHD4 Gene

CHD4 (Chromodomain Helicase DNA Binding Protein 4) is a Protein Coding gene. Diseases associated with CHD4 include Sifrim-Hitz-Weiss Syndrome and Cellular Schwannoma. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include hydrolase activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is CHD5.

UniProtKB/Swiss-Prot for CHD4 Gene

  • Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

Gene Wiki entry for CHD4 Gene

Additional gene information for CHD4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD4 Gene

Genomics for CHD4 Gene

GeneHancer (GH) Regulatory Elements for CHD4 Gene

Promoters and enhancers for CHD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J006602 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 688.5 +8.8 8796 7.4 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CHD4 ZNF384 ENSG00000219410 ENSG00000247853 NOP2 NCAPD2 ING4 SPSB2 ENSG00000126749 SCARNA12
GH12J006610 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 675.8 +1.0 1026 5.4 HDGF PKNOX1 CLOCK ARNT ARID4B DMAP1 ZNF2 YY1 ZNF766 E2F8 CHD4 LOC105369631 ZNF384 ENSG00000219410 ENSG00000247853 SPSB2 ENSG00000256967 C1RL-AS1 NCAPD2 LOC100419928
GH12J006630 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.4 -18.1 -18129 4.1 PKNOX1 SMAD1 NFIB ZNF48 ZNF121 ETV6 BCLAF1 IKZF2 RUNX3 SMAD5 CHD4 LPAR5 TAPBPL MRPL51 LAG3 VAMP1
GH12J006634 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 661.8 -21.4 -21414 2 HDGF PKNOX1 SIN3A YBX1 ZNF121 ZNF207 ATF7 RUNX3 ZNF263 JUNB CHD4 LPAR5 ZNF384 ENSG00000219410 ENSG00000247853 ING4 NCAPD2 LAG3 SPSB2 ENSG00000245667
GH12J006572 Promoter/Enhancer 1.3 EPDnew ENCODE 650.3 +44.1 44064 0.2 HDGF ELF3 CTCF IRF2 KLF1 MXI1 SAP130 SIN3A RAD21 ZNF48 NOP2 CHD4 ENSG00000247853 ENSG00000285238
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHD4 gene promoter:
  • E2F-2
  • GATA-2
  • E2F-5
  • E2F-4
  • E2F-3a
  • E2F-1
  • E2F
  • Max

Genomic Locations for CHD4 Gene

Genomic Locations for CHD4 Gene
chr12:6,570,082-6,614,524
(GRCh38/hg38)
Size:
44,443 bases
Orientation:
Minus strand
chr12:6,679,248-6,716,642
(GRCh37/hg19)
Size:
37,395 bases
Orientation:
Minus strand

Genomic View for CHD4 Gene

Genes around CHD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHD4 Gene

Proteins for CHD4 Gene

  • Protein details for CHD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14839-CHD4_HUMAN
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 4
    Protein Accession:
    Q14839
    Secondary Accessions:
    • Q8IXZ5

    Protein attributes for CHD4 Gene

    Size:
    1912 amino acids
    Molecular mass:
    218005 Da
    Quaternary structure:
    • Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (By similarity). Interacts directly with IKFZ1 in the NuRD complex. Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex (PubMed:9804427, PubMed:10204490, PubMed:15454082). Part of a complex containing ATR and HDAC2 (PubMed:10545197). Interacts with TRIM27 (PubMed:14530259). Interacts with ZGPAT; the interaction is direct (PubMed:19644445). Interacts with BCL6 (PubMed:15454082). Interacts with BRD4 (PubMed:21555454). Interacts with PCNT (PubMed:17626165). Interacts with SETX (PubMed:23149945). Interacts with HDAC1 (PubMed:27616479).
    Miscellaneous:
    • One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.

    Three dimensional structures from OCA and Proteopedia for CHD4 Gene

    Alternative splice isoforms for CHD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHD4 Gene

Post-translational modifications for CHD4 Gene

  • Ubiquitination at Lys1865, Lys1855, posLast=18521852, posLast=18371837, Lys1092, posLast=10571057, and posLast=504504
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CHD4 Gene

Domains & Families for CHD4 Gene

Gene Families for CHD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CHD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14839

UniProtKB/Swiss-Prot:

CHD4_HUMAN :
  • Belongs to the SNF2/RAD54 helicase family.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with CHD4: view

Function for CHD4 Gene

Molecular function for CHD4 Gene

UniProtKB/Swiss-Prot Function:
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
GENATLAS Biochemistry:
DNA binding protein with two chromatin organization (chromo) domains,and a helicase domain,4,component of the chromatin remodeling complex

Enzyme Numbers (IUBMB) for CHD4 Gene

Phenotypes From GWAS Catalog for CHD4 Gene

Gene Ontology (GO) - Molecular Function for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000978 contributes_to RNA polymerase II proximal promoter sequence-specific DNA binding HDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding HDA 16217013
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
GO:0003677 DNA binding TAS 9326634
genes like me logo Genes that share ontologies with CHD4: view
genes like me logo Genes that share phenotypes with CHD4: view

Human Phenotype Ontology for CHD4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CHD4 Gene

MGI Knock Outs for CHD4:
  • Chd4 Chd4<tm1b(EUCOMM)Wtsi>
  • Chd4 Chd4<tm1.2Kge>
  • Chd4 Chd4<tm1.2Bhlab>

Animal Model Products

miRNA for CHD4 Gene

miRTarBase miRNAs that target CHD4

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for CHD4 Gene

Localization for CHD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHD4 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase. {ECO:0000250 UniProtKB:Q6PDQ2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHD4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin HDA 16217013
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 17626165
GO:0005813 centrosome IDA 17626165
genes like me logo Genes that share ontologies with CHD4: view

Pathways & Interactions for CHD4 Gene

genes like me logo Genes that share pathways with CHD4: view

Pathways by source for CHD4 Gene

Gene Ontology (GO) - Biological Process for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 9326634
GO:0016575 histone deacetylation IEA --
genes like me logo Genes that share ontologies with CHD4: view

No data available for SIGNOR curated interactions for CHD4 Gene

Drugs & Compounds for CHD4 Gene

(3) Drugs for CHD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for CHD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with CHD4: view

Transcripts for CHD4 Gene

mRNA/cDNA for CHD4 Gene

Unigene Clusters for CHD4 Gene

Chromodomain helicase DNA binding protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a ·
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SP19: - - - - - - - - - - - - - - - - - - - - - -
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SP28:
SP29: - -
SP30: - - -
SP31: -
SP32: -
SP33:

ExUns: 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28a ·
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SP7: -
SP8: -
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SP19: - - - - - - - - - - - - - - - - - - - - - - - - - -
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ExUns: 28b ^ 29a · 29b · 29c ^ 30a · 30b · 30c ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b · 33c · 33d ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38a · 38b · 38c ^
SP1:
SP2: -
SP3:
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SP9: -
SP10: -
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SP18:
SP19: - - - -
SP20:
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SP23: -
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ExUns: 39a · 39b ^ 40 ^ 41 ^ 42a · 42b ^ 43 ^ 44a ·
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SP25: -
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Relevant External Links for CHD4 Gene

GeneLoc Exon Structure for
CHD4
ECgene alternative splicing isoforms for
CHD4

Expression for CHD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHD4 Gene

Protein differential expression in normal tissues from HIPED for CHD4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5) and Lymph node (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHD4 Gene



Protein tissue co-expression partners for CHD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHD4 Gene:

CHD4

SOURCE GeneReport for Unigene cluster for CHD4 Gene:

Hs.162233

Evidence on tissue expression from TISSUES for CHD4 Gene

  • Skin(4.6)
  • Liver(4.5)
  • Nervous system(4.4)
  • Lung(3.7)
  • Eye(3.3)
  • Intestine(3.3)
  • Pancreas(2.9)
  • Heart(2.5)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with CHD4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHD4 Gene

Orthologs for CHD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHD4 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHD4 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHD4 34 33
  • 94.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CHD4 34 33
  • 92.14 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chd4 33
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Chd4 16 34 33
  • 91.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHD4 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHD4 34 33
  • 78.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHD4 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chd4 33
  • 75.12 (n)
Str.16957 33
African clawed frog
(Xenopus laevis)
Amphibia b230399n07-prov 33
zebrafish
(Danio rerio)
Actinopterygii chd4b 34
  • 76 (a)
OneToMany
chd4a 34 33
  • 73.18 (n)
OneToMany
Dr.27188 33
fruit fly
(Drosophila melanogaster)
Insecta Chd3 34 35
  • 58 (a)
ManyToMany
Mi-2 34 35
  • 54 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea let-418 34 33
  • 59.33 (n)
ManyToMany
chd-3 34
  • 50 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHD1 34
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PKR2 33
  • 53.18 (n)
rice
(Oryza sativa)
Liliopsida Os.10905 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8509 34
  • 57 (a)
OneToMany
Cin.2842 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2842 33
Species where no ortholog for CHD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHD4 Gene

ENSEMBL:
Gene Tree for CHD4 (if available)
TreeFam:
Gene Tree for CHD4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHD4: view image

Paralogs for CHD4 Gene

Paralogs for CHD4 Gene

(13) SIMAP similar genes for CHD4 Gene using alignment to 5 proteins:

  • CHD4_HUMAN
  • F5GWX5_HUMAN
  • F5H596_HUMAN
  • F5H6N4_HUMAN
  • Q05CG6_HUMAN
genes like me logo Genes that share paralogs with CHD4: view

Variants for CHD4 Gene

Sequence variations from dbSNP and Humsavar for CHD4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1060499583 likely-pathogenic, Sifrim-Hitz-Weiss syndrome 6,587,518(-) A/C coding_sequence_variant, missense_variant
rs201992075 pathogenic, Sifrim-Hitz-Weiss syndrome, Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159] 6,581,131(-) C/T coding_sequence_variant, missense_variant
rs886039915 pathogenic, Sifrim-Hitz-Weiss syndrome, Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159] 6,591,713(-) C/T coding_sequence_variant, missense_variant
rs886039916 pathogenic, Sifrim-Hitz-Weiss syndrome, Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159] 6,593,191(-) G/T coding_sequence_variant, missense_variant
rs886039917 pathogenic, Sifrim-Hitz-Weiss syndrome, Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159] 6,588,383(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for CHD4 Gene

Variant ID Type Subtype PubMed ID
esv1065323 CNV deletion 17803354
esv2027881 CNV deletion 18987734
esv2675369 CNV deletion 23128226
nsv1068116 CNV deletion 25765185
nsv1070086 CNV deletion 25765185
nsv1110891 OTHER inversion 24896259
nsv509452 CNV insertion 20534489
nsv826210 CNV gain 20364138
nsv826211 CNV gain 20364138
nsv832322 CNV loss 17160897
nsv973982 CNV duplication 23825009

Variation tolerance for CHD4 Gene

Residual Variation Intolerance Score: 0.524% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHD4 Gene

Human Gene Mutation Database (HGMD)
CHD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHD4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD4 Gene

Disorders for CHD4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CHD4 Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sifrim-hitz-weiss syndrome
  • sihiwes
cellular schwannoma
  • cellular neurinoma
- elite association - COSMIC cancer census association via MalaCards
Search CHD4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CHD4_HUMAN
  • Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159]: An autosomal dominant syndrome characterized by mental retardation, variable congenital defects affecting cardiac, skeletal, and urogenital systems. Short stature, macrocephaly, hearing impairment, and facial dysmorphism are present in some patients. {ECO:0000269 PubMed:27479907, ECO:0000269 PubMed:27616479}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for CHD4

genes like me logo Genes that share disorders with CHD4: view

No data available for Genatlas for CHD4 Gene

Publications for CHD4 Gene

  1. Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. (PMID: 14530259) Shimono Y … Takahashi M (The Journal of biological chemistry 2003) 3 4 22 58
  2. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PMID: 10545197) Schmidt DR … Schreiber SL (Biochemistry 1999) 3 4 22 58
  3. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. (PMID: 9804427) Tong JK … Schreiber SL (Nature 1998) 3 4 22 58
  4. The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. (PMID: 7575689) Seelig HP … Genth E (Arthritis and rheumatism 1995) 2 3 4 58
  5. De Novo Mutations in CHD4, an ATP-Dependent Chromatin Remodeler Gene, Cause an Intellectual Disability Syndrome with Distinctive Dysmorphisms. (PMID: 27616479) Weiss K … Muenke M (American journal of human genetics 2016) 3 4 58

Products for CHD4 Gene