Aliases for CHD1L Gene
Aliases for CHD1L Gene
External Ids for CHD1L Gene
- HGNC: 1916
- Entrez Gene: 9557
- Ensembl: ENSG00000131778
- OMIM: 613039
- UniProtKB: Q86WJ1
Previous GeneCards Identifiers for CHD1L Gene
- GC01U990222
- GC01P143439
- GC01P144058
- GC01P144221
- GC01P143939
- GC01P145180
- GC01P146717
- GC01P120126
- GC01P147174
Summaries for CHD1L Gene
-
This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]
GeneCards Summary for CHD1L Gene
CHD1L (Chromodomain Helicase DNA Binding Protein 1 Like) is a Protein Coding gene. Diseases associated with CHD1L include Postcholecystectomy Syndrome and Fibrosarcoma Of Bone. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is SMARCA5.
UniProtKB/Swiss-Prot for CHD1L Gene
-
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD1L Gene
Genomics for CHD1L Gene
GeneHancer (GH) Regulatory Elements for CHD1L Gene
Promoters and enhancers for CHD1L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around CHD1L on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the CHD1L gene promoter:
-
- AREB6
- AML1a
- STAT5B
- NF-kappaB2
- NF-kappaB1
- NF-kappaB
- Nkx6-1
- STAT5A
- MyoD
- Msx-1
Regulatory Element Products
Genomic Locations for CHD1L Gene
Genomic Locations for CHD1L Gene
- chr1:147,242,641-147,295,766
- (GRCh38/hg38)
- Size:
- 53,126 bases
- Orientation:
- Plus strand
- chr1:146,714,291-146,767,443
- (GRCh37/hg19)
- Size:
- 53,153 bases
- Orientation:
- Plus strand
Genomic View for CHD1L Gene
Genes around CHD1L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.1 by Entrez Gene
- 1q21.1 by HGNC
- 1q21.1 by Ensembl
CHD1L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CHD1L Gene
Proteins for CHD1L Gene
-
Protein details for CHD1L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86WJ1-CHD1L_HUMAN
- Recommended name:
- Chromodomain-helicase-DNA-binding protein 1-like
- Protein Accession:
- Q86WJ1
- A5YM64
- B4DDE1
- B5MDZ7
- Q53EZ3
- Q5VXX7
- Q6DD94
- Q6PK83
- Q86XH3
- Q96HF7
- Q96SP3
- Q9BVJ1
- Q9NVV8
Protein attributes for CHD1L Gene
- Size:
- 897 amino acids
- Molecular mass:
- 100984 Da
- Quaternary structure:
-
- Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).
- SequenceCaution:
-
- Sequence=BAB55248.1; Type=Frameshift; Positions=597; Evidence={ECO:0000305};
Protein Expression for CHD1L Gene
Post-translational modifications for CHD1L Gene
Other Protein References for CHD1L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001335386.1
- NP_001243267.1
- NP_001335387.1
- NP_001335384.1
- NP_001335394.1
- NP_001335382.1
- NP_001335392.1
- NP_001335388.1
- NP_078844.2
- NP_004275.4
- XP_024306817.1
- NP_001243266.1
- NP_001335385.1
- NP_001335395.1
- NP_001335383.1
- NP_001335393.1
- XP_024306819.1
- NP_001335380.1
- NP_001335390.1
- NP_001335389.1
- XP_024306818.1
- NP_001243265.1
- NP_001335381.1
- NP_001335391.1
Antibody Products
- R&D Systems Antibodies for CHD1L (CHD1L)
-
Custom Antibody ServicesOriGene Antibodies for CHD1L
- Novus Biologicals Antibodies for CHD1L
-
Abcam antibodies for CHD1L
- Invitrogen Antibodies for CHD1L (AFLGC-CHD1L)
- GeneTex CHD1L Antibody for CHD1L
-
Boster Bio Antibodies for CHD1L
-
Santa Cruz Biotechnology (SCBT) Antibodies for CHD1L
Protein Products
-
OriGene Purified Proteins for CHD1L
- Search Origene for MassSpec and Protein Over-expression Lysates for CHD1L
- Origene Custom Protein Services for CHD1L
- antibodies-online: Search results for 3 available CHD1L Proteins ranked by validation data
- Compare Top CHD1L Proteins
-
Quality Products:
- Search GeneTex for Proteins for CHD1L
Assay Products
No data available for DME Specific Peptides for CHD1L Gene
Domains & Families for CHD1L Gene
Gene Families for CHD1L Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for CHD1L Gene
Suggested Antigen Peptide Sequences for CHD1L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86WJ1UniProtKB/Swiss-Prot:
CHD1L_HUMAN :- The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
- Belongs to the SNF2/RAD54 helicase family.
- Domain:
-
- The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
- Family:
-
- Belongs to the SNF2/RAD54 helicase family.
Function for CHD1L Gene
Molecular function for CHD1L Gene
- UniProtKB/Swiss-Prot Function:
- DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + H(2)O = ADP + phosphate.
Enzyme Numbers (IUBMB) for CHD1L Gene
Phenotypes From GWAS Catalog for CHD1L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IDA | 19661379 |
| GO:0004003 | ATP-dependent DNA helicase activity | TAS | 19661379 |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 19661379 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for CHD1L Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for CHD1L
- Cyagen custom Knockout/knockin (KOKI) mouse models for CHD1L
-
CRISPR Products
-
OriGene CRISPR knockouts for CHD1L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHD1L
- genomics-online: gRNA clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
- Applied Biological Materials CRISPR for CHD1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHD1L
- GenScript: Design CRISPR guide RNA sequences for CHD1L
miRNA for CHD1L Gene
- miRTarBase miRNAs that target CHD1L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHD1L
- Browse OriGene Inhibitory RNA Products For CHD1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHD1L
- genomics-online: shRNA clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
Clone Products
-
OriGene ORF clones in human for CHD1L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CHD1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHD1L
- Applied Biological Materials Clones for CHD1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CHD1L
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHD1L Gene
Localization for CHD1L Gene
Subcellular locations from UniProtKB/Swiss-Prot for CHD1L Gene
- Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 19661379 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for CHD1L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | Chromatin Regulation / Acetylation | ||
| 3 | DNA Double-Strand Break Repair |
.53
|
|
| 4 | Nucleotide excision repair | ||
Pathways by source for CHD1L Gene
5 Reactome pathways for CHD1L Gene
1 Cell Signaling Technology pathway for CHD1L Gene
Interacting Proteins for CHD1L Gene
Selected Interacting proteins:
Q86WJ1-CHD1L_HUMAN
ENSP00000358262
for CHD1L Gene via
MINT
STRING
UniProtKB
IID
GPS-Prot Interaction Network for CHD1L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000717 | nucleotide-excision repair, DNA duplex unwinding | TAS | -- |
| GO:0006281 | DNA repair | TAS | 19661379 |
| GO:0006293 | nucleotide-excision repair, preincision complex stabilization | TAS | -- |
| GO:0006294 | nucleotide-excision repair, preincision complex assembly | TAS | -- |
| GO:0006295 | nucleotide-excision repair, DNA incision, 3-to lesion | TAS | -- |
No data available for SIGNOR curated interactions for CHD1L Gene
Drugs & Compounds for CHD1L Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor | 58-64-0 |
|
Drug Products
Transcripts for CHD1L Gene
mRNA/cDNA for CHD1L Gene
- (24) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (229) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000622533 2937 bps (uc057kel.1)
- ENST00000369258 2967 bps (uc001epm.6)
- ENST00000467213 2782 bps (uc057kem.1)
- ENST00000369259 2358 bps (uc001epo.6)
- ENST00000488864 2415 bps (uc057ken.1)
Unigene Clusters for CHD1L Gene
CRISPR Products
-
OriGene CRISPR knockouts for CHD1L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHD1L
- genomics-online: gRNA clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
- Applied Biological Materials CRISPR for CHD1L
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CHD1L
- GenScript: Design CRISPR guide RNA sequences for CHD1L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CHD1L
- Browse OriGene Inhibitory RNA Products For CHD1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHD1L
- genomics-online: shRNA clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
Clone Products
-
OriGene ORF clones in human for CHD1L
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for CHD1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHD1L
- Applied Biological Materials Clones for CHD1L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: |
| ExUns: | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b | ^ | 24 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||||
| SP12: | |||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||
| SP15: |
Expression for CHD1L Gene
This gene is overexpressed in Lymph node (22.5) and Testis (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHD1L Gene
NURSA nuclear receptor signaling pathways regulating expression of CHD1L Gene:
CHD1LSOURCE GeneReport for Unigene cluster for CHD1L Gene:
Hs.191164mRNA Expression by UniProt/SwissProt for CHD1L Gene:
Q86WJ1-CHD1L_HUMAN
Tissue specificity:
Frequently overexpressed in hepatomacellular carcinomas.
Evidence on tissue expression from TISSUES for CHD1L Gene
- Nervous system(4.6)
- Liver(4.4)
- Skin(4.3)
- Eye(4.1)
- Blood(2.4)
Primer Products
-
OriGene qPCR primer pairs for CHD1L
- genomics-online: primer clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHD1L Gene
Orthologs for CHD1L Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CHD1L 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | CHD1L 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CHD1L 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Chd1l 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Chd1l 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CHD1L 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CHD1L 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CHD1L 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CHD1L 34 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | chd1l 34 33 |
|
OneToOne | |
| zgc56084 33 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ISW2 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT2G44980 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os03g0101700 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for CHD1L was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for CHD1L Gene
- ENSEMBL:
- Gene Tree for CHD1L (if available)
- TreeFam:
- Gene Tree for CHD1L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CHD1L: view image
Paralogs for CHD1L Gene
Variants for CHD1L Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs201333837 | uncertain-significance, Congenital anomalies of kidney and urinary tract | 147,264,552(+) | G/A | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs369564534 | uncertain-significance, Congenital anomalies of kidney and urinary tract | 147,286,485(+) | A/G | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs782687350 | uncertain-significance, Congenital anomalies of kidney and urinary tract | 147,287,691(+) | G/A/C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs1064797118 | uncertain-significance, not provided | 147,285,355(+) | C/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs149913688 | uncertain-significance, not specified | 147,286,458(+) | C/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv327n100 | CNV | gain | 25217958 |
| dgv66e199 | CNV | deletion | 23128226 |
| esv2761299 | CNV | gain+loss | 21179565 |
| esv2761654 | CNV | loss | 21179565 |
| esv3894112 | CNV | loss | 25118596 |
| nsv1003688 | CNV | gain | 25217958 |
| nsv1005055 | CNV | loss | 25217958 |
| nsv1132304 | CNV | duplication | 24896259 |
| nsv437047 | CNV | loss | 16327808 |
| nsv509457 | CNV | insertion | 20534489 |
| nsv510962 | OTHER | complex | 20534489 |
| nsv547676 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
11.20;
92.42% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CHD1L Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD1L Gene
Disorders for CHD1L Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| postcholecystectomy syndrome |
|
|
| fibrosarcoma of bone |
|
|
Search CHD1L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CHD1L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CHD1L Gene
Publications for CHD1L Gene
- Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. (PMID: 19661379) Ahel D … Boulton SJ (Science (New York, N.Y.) 2009) 3 4 22 58
- A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58
- Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. (PMID: 18023026) Ma NF … Guan XY (Hepatology (Baltimore, Md.) 2008) 3 4 58
- A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D … Ferrucci L (PLoS genetics 2008) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for CHD1L Gene
- R&D Systems Antibodies for CHD1L (CHD1L)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
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- Custom Antibody ServicesOriGene Antibodies for CHD1L
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- OriGene Purified Proteins for CHD1L
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- GenScript: Next-day shipping of latest version cDNA ORF clones for CHD1L in any vector
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- GenScript Custom overexpressing Cell Line Services for CHD1L
- GenScript: Design CRISPR guide RNA sequences for CHD1L
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- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Taconic Biosciences Mouse Models for CHD1L
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
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- antibodies-online: Search results for 48 available CHD1L Antibodies ranked by validation data
- Compare Top CHD1L Antibodies
- antibodies-online: Search results for available CHD1L related products ranked by validation data
- antibodies-online: Search results for 3 available CHD1L Proteins ranked by validation data
- Compare Top CHD1L Proteins
- Quality Products:
- GeneTex CHD1L Antibody for CHD1L
- Search GeneTex for Proteins for CHD1L
- Santa Cruz Biotechnology (SCBT) Antibodies for CHD1L
- Search Santa Cruz Biotechnology (SCBT) for CHD1L siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CHD1L
- Horizon Cell Lines for CHD1L
- genomics-online: cdna clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
- orf clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
- genomics-online: gRNA clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
- genomics-online: primer clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
- genomics-online: shRNA clones - Search results for 82 available CHD1L gene related products
- Overview of 82 available CHD1L gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CHD1L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CHD1L
- GeneCopoeia miRNA 3'UTR Target clone products for CHD1L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHD1L
- Boster Bio Antibodies for CHD1L
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Sources for CHD1L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (24) DrugBank
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- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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- (91) Illumina
- (92) COMPARTMENTS
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- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
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