Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHCHD6 Gene

Aliases for CHCHD6 Gene

  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 2 3 5
  • Coiled-Coil-Helix Cristae Morphology Protein 1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 23 2 3
  • CHCM1 3 4
  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6, Mitochondrial 3
  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6 4
  • Coiled Coil Helix Cristae Morphology 1 3
  • Coiled-Coil-Helix Cristae Morphology 1 2
  • MICOS Complex Subunit MIC25 3
  • PPP1R23 3
  • Mic25 3
  • MIC25 4

External Ids for CHCHD6 Gene

Previous GeneCards Identifiers for CHCHD6 Gene

  • GC03P127744
  • GC03P127905
  • GC03P126423
  • GC03P123803

Summaries for CHCHD6 Gene

GeneCards Summary for CHCHD6 Gene

CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is CHCHD3.

UniProtKB/Swiss-Prot for CHCHD6 Gene

  • Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

Additional gene information for CHCHD6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHCHD6 Gene

Genomics for CHCHD6 Gene

GeneHancer (GH) Regulatory Elements for CHCHD6 Gene

Promoters and enhancers for CHCHD6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J126703 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 657.1 +0.0 41 1.8 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS ZNF263 SP3 CHCHD6 TPRA1 GC03P126709
GH03J126750 Enhancer 1.1 Ensembl ENCODE 11 +48.2 48219 4.4 ELF3 FOXA2 RB1 NFIB ARID4B SIN3A ZNF48 RAD21 ZNF335 EGR1 CHCHD6 GC03P126746 RCC2P4 GC03P126709
GH03J126679 Enhancer 1 Ensembl ENCODE 11.9 -24.8 -24833 0.8 RB1 SIN3A ZNF2 ZNF48 RAD21 GLIS2 ZNF143 RCOR1 EGR2 SMARCA5 CHCHD6 TXNRD3 LOC645852
GH03J126746 Enhancer 0.7 Ensembl ENCODE 11.1 +42.6 42569 0.4 MITF CTCF ATF1 L3MBTL2 ZBTB33 RAD21 MGA GC03P126746 CHCHD6 RCC2P4 GC03P126709
GH03J126780 Enhancer 0.9 Ensembl ENCODE 6.8 +78.7 78662 4.6 PKNOX1 KLF1 TEAD4 MAX RAD21 TCF12 ZFHX2 NCOR1 POLR2A SMC3 PLXNA1 CHCHD6 PIR54010 RCC2P4 GC03P126709
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHCHD6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHCHD6 gene promoter:
  • Nkx3-1 v4
  • Nkx3-1 v3
  • Nkx3-1 v2
  • Nkx3-1 v1
  • Nkx3-1
  • oct-B2
  • Oct-B1
  • POU2F1a
  • POU2F1
  • oct-B3

Genomic Locations for CHCHD6 Gene

Genomic Locations for CHCHD6 Gene
256,201 bases
Plus strand
256,187 bases
Plus strand

Genomic View for CHCHD6 Gene

Genes around CHCHD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHCHD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHCHD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHCHD6 Gene

Proteins for CHCHD6 Gene

  • Protein details for CHCHD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MICOS complex subunit MIC25
    Protein Accession:
    Secondary Accessions:
    • D6R9U0
    • D6RIB4
    • H8Y0Y7

    Protein attributes for CHCHD6 Gene

    235 amino acids
    Molecular mass:
    26458 Da
    Quaternary structure:
    • Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (PubMed:17624330, PubMed:22228767, PubMed:25781180, PubMed:25997101). The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with DISC1 (PubMed:22228767). Interacts with DISC1 (PubMed:22228767). Interacts with IMMT/MIC60 (PubMed:22228767, PubMed:25997101).

neXtProt entry for CHCHD6 Gene

Post-translational modifications for CHCHD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CHCHD6 Gene

Domains & Families for CHCHD6 Gene

Protein Domains for CHCHD6 Gene


Suggested Antigen Peptide Sequences for CHCHD6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
  • Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
genes like me logo Genes that share domains with CHCHD6: view

Function for CHCHD6 Gene

Molecular function for CHCHD6 Gene

UniProtKB/Swiss-Prot Function:
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
UniProtKB/Swiss-Prot Induction:
Down-regulated following genotoxic stress.

Phenotypes From GWAS Catalog for CHCHD6 Gene

Gene Ontology (GO) - Molecular Function for CHCHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22228767
genes like me logo Genes that share ontologies with CHCHD6: view
genes like me logo Genes that share phenotypes with CHCHD6: view

Animal Model Products

CRISPR Products

miRNA for CHCHD6 Gene

miRTarBase miRNAs that target CHCHD6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHCHD6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHCHD6 Gene

Localization for CHCHD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHCHD6 Gene

Mitochondrion inner membrane; Lipid-anchor. Mitochondrion.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHCHD6 gene
Compartment Confidence
mitochondrion 5
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHCHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IMP 22228767
GO:0005743 mitochondrial inner membrane IDA,IEA 22228767
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0061617 MICOS complex IDA,IEA 25781180
genes like me logo Genes that share ontologies with CHCHD6: view

Pathways & Interactions for CHCHD6 Gene

SuperPathways for CHCHD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHCHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 22228767
GO:0008053 mitochondrial fusion IBA --
GO:0042407 cristae formation IMP 22228767
genes like me logo Genes that share ontologies with CHCHD6: view

No data available for Pathways by source and SIGNOR curated interactions for CHCHD6 Gene

Drugs & Compounds for CHCHD6 Gene

No Compound Related Data Available

Transcripts for CHCHD6 Gene

Unigene Clusters for CHCHD6 Gene

Coiled-coil-helix-coiled-coil-helix domain containing 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHCHD6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHCHD6 Gene

No ASD Table

Relevant External Links for CHCHD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHCHD6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHCHD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CHCHD6 Gene

This gene is overexpressed in Frontal cortex (17.7), Platelet (10.4), and Testis (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHCHD6 Gene

Protein tissue co-expression partners for CHCHD6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHCHD6 Gene:


SOURCE GeneReport for Unigene cluster for CHCHD6 Gene:


Evidence on tissue expression from TISSUES for CHCHD6 Gene

  • Lung(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CHCHD6: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHCHD6 Gene

Orthologs for CHCHD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHCHD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHCHD6 34 33
  • 99.15 (n)
(Canis familiaris)
Mammalia CHCHD6 34 33
  • 82.54 (n)
(Mus musculus)
Mammalia Chchd6 16 34 33
  • 77.87 (n)
(Rattus norvegicus)
Mammalia Chchd6 33
  • 77.25 (n)
(Bos Taurus)
Mammalia CHCHD6 34 33
  • 74.17 (n)
(Monodelphis domestica)
Mammalia CHCHD6 34
  • 38 (a)
(Gallus gallus)
Aves CHCHD6 33
  • 63.36 (n)
(Anolis carolinensis)
Reptilia CHCHD6 34
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chchd6 33
  • 56.13 (n)
(Danio rerio)
Actinopterygii chchd6a 34 33
  • 53.22 (n)
chchd6b 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5473 34
  • 25 (a)
Species where no ortholog for CHCHD6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHCHD6 Gene

Gene Tree for CHCHD6 (if available)
Gene Tree for CHCHD6 (if available)
Evolutionary constrained regions (ECRs) for CHCHD6: view image

Paralogs for CHCHD6 Gene

Paralogs for CHCHD6 Gene

(1) SIMAP similar genes for CHCHD6 Gene using alignment to 4 proteins:

  • H0Y922_HUMAN
genes like me logo Genes that share paralogs with CHCHD6: view

Variants for CHCHD6 Gene

Sequence variations from dbSNP and Humsavar for CHCHD6 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000020815 -- 126,938,955(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000030632 -- 126,814,623(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000047658 -- 126,914,761(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000070554 -- 126,940,752(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000090400 -- 126,741,248(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHCHD6 Gene

Variant ID Type Subtype PubMed ID
dgv8553n54 CNV loss 21841781
dgv8554n54 CNV loss 21841781
dgv8555n54 CNV gain+loss 21841781
dgv8556n54 CNV gain+loss 21841781
dgv8557n54 CNV loss 21841781
dgv8558n54 CNV loss 21841781
dgv8559n54 CNV loss 21841781
esv1002711 CNV deletion 20482838
esv1444905 CNV deletion 17803354
esv22081 CNV loss 19812545
esv2552936 CNV loss 19546169
esv2660854 CNV deletion 23128226
esv2666215 CNV deletion 23128226
esv2666675 CNV deletion 23128226
esv2725875 CNV deletion 23290073
esv2725876 CNV deletion 23290073
esv2725877 CNV deletion 23290073
esv2725878 CNV deletion 23290073
esv2725879 CNV deletion 23290073
esv2725880 CNV deletion 23290073
esv2725881 CNV deletion 23290073
esv3304233 CNV mobile element insertion 20981092
esv33263 CNV gain 17666407
esv3434631 CNV insertion 20981092
esv3562511 CNV deletion 23714750
esv3597685 CNV loss 21293372
esv3597687 CNV loss 21293372
esv3597688 CNV loss 21293372
esv3597689 CNV loss 21293372
esv3701 CNV loss 18987735
nsv1001475 CNV loss 25217958
nsv1073245 CNV deletion 25765185
nsv1144999 CNV deletion 24896259
nsv1149407 CNV duplication 26484159
nsv1152506 CNV deletion 26484159
nsv237087 CNV deletion 16902084
nsv3986 CNV insertion 18451855
nsv460846 CNV loss 19166990
nsv474950 CNV novel sequence insertion 20440878
nsv511217 CNV loss 21212237
nsv526947 CNV loss 19592680
nsv591525 CNV loss 21841781
nsv591527 CNV gain 21841781
nsv821409 CNV deletion 20802225
nsv829718 CNV gain 17160897
nsv829719 CNV gain 17160897
nsv955339 CNV deletion 24416366
nsv967061 CNV duplication 23825009

Variation tolerance for CHCHD6 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.02; 90.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHCHD6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHCHD6 Gene

Disorders for CHCHD6 Gene

Additional Disease Information for CHCHD6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CHCHD6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHCHD6 Gene

Publications for CHCHD6 Gene

  1. CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. (PMID: 22228767) An J … Sheikh MS (The Journal of biological chemistry 2012) 2 3 4 58
  2. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. (PMID: 17624330) Xie J … Capaldi RA (FEBS letters 2007) 2 3 4 58
  3. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. (PMID: 25781180) Ott C … Kozjak-Pavlovic V (PloS one 2015) 3 4 58
  4. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. (PMID: 25997101) Guarani V … Harper JW (eLife 2015) 3 4 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for CHCHD6 Gene

Sources for CHCHD6 Gene

Loading form....