Aliases for CHAMP1 Gene
External Ids for CHAMP1 Gene
Previous HGNC Symbols for CHAMP1 Gene
Previous GeneCards Identifiers for CHAMP1 Gene
This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. [provided by RefSeq, Jul 2017]
GeneCards Summary for CHAMP1 Gene
CHAMP1 (Chromosome Alignment Maintaining Phosphoprotein 1) is a Protein Coding gene. Diseases associated with CHAMP1 include Mental Retardation, Autosomal Dominant 40 and Autosomal Dominant Non-Syndromic Intellectual Disability. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.
UniProtKB/Swiss-Prot Summary for CHAMP1 Gene
Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.