Aliases for CHAF1B Gene
External Ids for CHAF1B Gene
Previous GeneCards Identifiers for CHAF1B Gene
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]
GeneCards Summary for CHAF1B Gene
CHAF1B (Chromatin Assembly Factor 1 Subunit B) is a Protein Coding gene. Diseases associated with CHAF1B include Attention Deficit-Hyperactivity Disorder and Luminal Breast Carcinoma A. Gene Ontology (GO) annotations related to this gene include chromatin binding and unfolded protein binding.
UniProtKB/Swiss-Prot Summary for CHAF1B Gene
Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.