Aliases for CHAF1A Gene
External Ids for CHAF1A Gene
Previous GeneCards Identifiers for CHAF1A Gene
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CHAF1A Gene
CHAF1A (Chromatin Assembly Factor 1 Subunit A) is a Protein Coding gene. Diseases associated with CHAF1A include Prostate Squamous Cell Carcinoma and Alpha Thalassemia-Intellectual Disability Syndrome Type 1. Among its related pathways are Chromatin Regulation / Acetylation and Nanoparticle triggered autophagic cell death. Gene Ontology (GO) annotations related to this gene include identical protein binding and unfolded protein binding.
UniProtKB/Swiss-Prot Summary for CHAF1A Gene
Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci.