Aliases for CHADL Gene

Aliases for CHADL Gene

  • Chondroadherin Like 2 3 5
  • SLRR4B 2 3 4
  • Chondroadherin-Like Protein 3 4
  • Chondroadherin-Like 2
  • CHADL 5

External Ids for CHADL Gene

Previous GeneCards Identifiers for CHADL Gene

  • GC22U900391
  • GC22M039955
  • GC22M041625
  • GC22M024589
  • GC22M041213
  • GC22M042788
  • GC22M042900
  • GC22M042958
  • GC22M044568
  • GC22M041357
  • GC22M041356
  • GC22M041490
  • GC22M041897
  • GC22M042327
  • GC22M042676

Summaries for CHADL Gene

GeneCards Summary for CHADL Gene

CHADL (Chondroadherin Like) is a Protein Coding gene. Diseases associated with CHADL include Polyomavirus-Associated Nephropathy and Hantavirus Hemorrhagic Fever With Renal Syndrome. Gene Ontology (GO) annotations related to this gene include collagen binding and collagen fibril binding. An important paralog of this gene is LRIG1.

UniProtKB/Swiss-Prot Summary for CHADL Gene

  • Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHADL Gene

Genomics for CHADL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CHADL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHADL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHADL

Top Transcription factor binding sites by QIAGEN in the CHADL gene promoter:
  • AP-4
  • Brachyury
  • c-Myc
  • C/EBPalpha
  • CREB
  • E47
  • LCR-F1
  • Max
  • Olf-1
  • Pax-5

Genomic Locations for CHADL Gene

Genomic Locations for CHADL Gene
chr22:41,229,510-41,241,771
(GRCh38/hg38)
Size:
12,262 bases
Orientation:
Minus strand
chr22:41,625,514-41,636,938
(GRCh37/hg19)
Size:
11,425 bases
Orientation:
Minus strand

Genomic View for CHADL Gene

Genes around CHADL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHADL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHADL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHADL Gene

Proteins for CHADL Gene

  • Protein details for CHADL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUI6-CHADL_HUMAN
    Recommended name:
    Chondroadherin-like protein
    Protein Accession:
    Q6NUI6
    Secondary Accessions:
    • Q05CY2
    • Q4G0S0
    • Q5JY13
    • Q86XY1
    • Q96E60

    Protein attributes for CHADL Gene

    Size:
    762 amino acids
    Molecular mass:
    82388 Da
    Quaternary structure:
    • Associates with collagen and binds to collagen fibrils.
    SequenceCaution:
    • Sequence=AAH19839.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAH68590.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHADL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHADL Gene

Post-translational modifications for CHADL Gene

  • Glycosylation at Asn52 and Asn626
  • Modification sites at PhosphoSitePlus

Other Protein References for CHADL Gene

No data available for DME Specific Peptides for CHADL Gene

Domains & Families for CHADL Gene

Gene Families for CHADL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CHADL Gene

InterPro:
Blocks:
  • Cysteine-rich flanking region, N-terminal
  • Leucine-rich repeat signature
  • Cysteine-rich flanking region, C-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for CHADL Gene

GenScript: Design optimal peptide antigens:
  • Chondroadherin-like protein (CHADL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6NUI6

UniProtKB/Swiss-Prot:

CHADL_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
genes like me logo Genes that share domains with CHADL: view

Function for CHADL Gene

Molecular function for CHADL Gene

UniProtKB/Swiss-Prot Function:
Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment.

Phenotypes From GWAS Catalog for CHADL Gene

Gene Ontology (GO) - Molecular Function for CHADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005518 collagen binding IDA 25451920
GO:0030021 extracellular matrix structural constituent conferring compression resistance ISS --
GO:0098633 collagen fibril binding IDA 25451920
genes like me logo Genes that share ontologies with CHADL: view

Phenotypes for CHADL Gene

genes like me logo Genes that share phenotypes with CHADL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHADL

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHADL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHADL Gene

Localization for CHADL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHADL Gene

Secreted. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHADL gene
Compartment Confidence
extracellular 5
mitochondrion 2
peroxisome 0
lysosome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for CHADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0031012 extracellular matrix IBA 21873635
GO:0062023 collagen-containing extracellular matrix IEA,IDA 25451920
genes like me logo Genes that share ontologies with CHADL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHADL Gene

Pathways & Interactions for CHADL Gene

PathCards logo

SuperPathways for CHADL Gene

No Data Available

Interacting Proteins for CHADL Gene

Gene Ontology (GO) - Biological Process for CHADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032331 negative regulation of chondrocyte differentiation IEA,ISS --
GO:1904027 negative regulation of collagen fibril organization IDA 25451920
genes like me logo Genes that share ontologies with CHADL: view

No data available for Pathways by source and SIGNOR curated interactions for CHADL Gene

Drugs & Compounds for CHADL Gene

No Compound Related Data Available

Transcripts for CHADL Gene

mRNA/cDNA for CHADL Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHADL

Alternative Splicing Database (ASD) splice patterns (SP) for CHADL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3:

Relevant External Links for CHADL Gene

GeneLoc Exon Structure for
CHADL

Expression for CHADL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHADL Gene

mRNA differential expression in normal tissues according to GTEx for CHADL Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.5) and Brain - Substantia nigra (x5.2).

Protein differential expression in normal tissues from HIPED for CHADL Gene

This gene is overexpressed in Heart (50.3), Retina (9.3), and Ovary (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHADL Gene



Protein tissue co-expression partners for CHADL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHADL

SOURCE GeneReport for Unigene cluster for CHADL Gene:

Hs.344488

Evidence on tissue expression from TISSUES for CHADL Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with CHADL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHADL Gene

Orthologs for CHADL Gene

This gene was present in the common ancestor of animals.

Orthologs for CHADL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CHADL 30 31
  • 99.52 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CHADL 30 31
  • 86.59 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CHADL 30 31
  • 85.96 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Chadl 30
  • 84.2 (n)
Mouse
(Mus musculus)
Mammalia Chadl 30 17 31
  • 83.82 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CHADL 31
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CHADL 31
  • 44 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CHADL 30 31
  • 63.66 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 19 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia chadl 30
  • 52.3 (n)
Zebrafish
(Danio rerio)
Actinopterygii chadlb 30 31
  • 54.81 (n)
OneToMany
chadla 31
  • 38 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta haf 31
  • 9 (a)
OneToMany
Species where no ortholog for CHADL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CHADL Gene

ENSEMBL:
Gene Tree for CHADL (if available)
TreeFam:
Gene Tree for CHADL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHADL: view image

Paralogs for CHADL Gene

(3) SIMAP similar genes for CHADL Gene using alignment to 3 proteins:

  • CHADL_HUMAN
  • B0QYT2_HUMAN
  • H0Y4I5_HUMAN
genes like me logo Genes that share paralogs with CHADL: view

Variants for CHADL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHADL Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs9619954 - p.Asp721Asn
rs9619955 - p.Gln710Arg

Additional dbSNP identifiers (rs#s) for CHADL Gene

Structural Variations from Database of Genomic Variants (DGV) for CHADL Gene

Variant ID Type Subtype PubMed ID
esv3647794 CNV loss 21293372
nsv459888 CNV gain 19166990
nsv524585 CNV loss 19592680
nsv589049 CNV gain 21841781
nsv589050 CNV gain 21841781

Variation tolerance for CHADL Gene

Gene Damage Index Score: 6.66; 78.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHADL Gene

Human Gene Mutation Database (HGMD)
CHADL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHADL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHADL Gene

Disorders for CHADL Gene

MalaCards: The human disease database

(2) MalaCards diseases for CHADL Gene - From: DISEASES

Disorder Aliases PubMed IDs
polyomavirus-associated nephropathy
  • polyomavirus associated nephropathy
hantavirus hemorrhagic fever with renal syndrome
  • hemorrhagic fever, russian
- elite association - COSMIC cancer census association via MalaCards
Search CHADL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHADL

genes like me logo Genes that share disorders with CHADL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHADL Gene

Publications for CHADL Gene

  1. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation. (PMID: 25451920) Tillgren V … Kalamajski S (The Journal of biological chemistry 2015) 2 3 4
  2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  3. Whole-genome sequencing identifies rare genotypes in COMP and CHADL associated with high risk of hip osteoarthritis. (PMID: 28319091) Styrkarsdottir U … Stefansson K (Nature genetics 2017) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) Schizophrenia Working Group of the Psychiatric Genomics Consortium (Nature 2014) 3
  5. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. (PMID: 22261194) Barallobre-Barreiro J … Mayr M (Circulation 2012) 3

Products for CHADL Gene

Sources for CHADL Gene