Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. [provided by RefSeq, Jul 2008] See more...

Aliases for CHAD Gene

Aliases for CHAD Gene

  • Chondroadherin 2 3 4 5
  • SLRR4A 2 3 4
  • Cartilage Leucine-Rich Protein 3 4
  • Chondroadherin Proteoglycan 2 3
  • CHAD 5

External Ids for CHAD Gene

Previous GeneCards Identifiers for CHAD Gene

  • GC17M048254
  • GC17M051023
  • GC17M048883
  • GC17M049016
  • GC17M045896
  • GC17M048541
  • GC17M043909

Summaries for CHAD Gene

Entrez Gene Summary for CHAD Gene

  • Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHAD Gene

CHAD (Chondroadherin) is a Protein Coding gene. Diseases associated with CHAD include Calcific Tendinitis and Autonomic Peripheral Neuropathy. Among its related pathways are Focal Adhesion and PI3K-Akt signaling pathway. An important paralog of this gene is CHADL.

UniProtKB/Swiss-Prot Summary for CHAD Gene

  • Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CHAD Gene

Genomics for CHAD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CHAD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J050469 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 250.7 +0.8 780 1 ZBTB33 MAX CHAD HSALNG0117302 HSALNG0117303 ACSF2 RSAD1 SPATA20 HSALNG0117299 HSALNG0117301
GH17J050468 Promoter/Enhancer 0.6 EPDnew dbSUPER 250.7 +1.6 1557 0.1 MAX CHAD HSALNG0117301 HSALNG0117302 ACSF2 HSALNG0117299
GH17J050472 Enhancer 0.6 Ensembl dbSUPER 250.7 -1.0 -1020 0.2 ZIC2 ZNF341 KLF1 ZNF335 CHAD HSALNG0117302 HSALNG0117303 HSALNG0117304 HSALNG0117305 HSALNG0117299 RSAD1 ACSF2
GH17J050470 Enhancer 0.3 Ensembl dbSUPER 250.7 +1.8 1780 0.2 CHAD HSALNG0117301 HSALNG0117302 HSALNG0117299 ACSF2
GH17J050171 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.9 +277.4 277359 42 EZH2 BCLAF1 ZNF654 ZNF207 NCOR1 ZNF600 MYC IKZF1 JUND ZNF580 COL1A1 HSALNG0117266 SGCA ENSG00000262837 LUC7L3 TMEM92-AS1 TMEM92 XYLT2 PPP1R9B ENSG00000204584
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CHAD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CHAD

Top Transcription factor binding sites by QIAGEN in the CHAD gene promoter:
  • Brachyury
  • HNF-4alpha1
  • HNF-4alpha2
  • MRF-2
  • NF-1
  • NF-1/L
  • p53
  • Pax-2
  • Pax-2a

Genomic Locations for CHAD Gene

Latest Assembly
chr17:50,464,492-50,469,881
(GRCh38/hg38)
Size:
5,390 bases
Orientation:
Minus strand

Previous Assembly
chr17:48,541,857-48,546,241
(GRCh37/hg19 by Entrez Gene)
Size:
4,385 bases
Orientation:
Minus strand

chr17:48,541,857-48,546,327
(GRCh37/hg19 by Ensembl)
Size:
4,471 bases
Orientation:
Minus strand

Genomic View for CHAD Gene

Genes around CHAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAD Gene

Proteins for CHAD Gene

  • Protein details for CHAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15335-CHAD_HUMAN
    Recommended name:
    Chondroadherin
    Protein Accession:
    O15335
    Secondary Accessions:
    • A8K812
    • Q6GTU0
    • Q96RJ5

    Protein attributes for CHAD Gene

    Size:
    359 amino acids
    Molecular mass:
    40476 Da
    Quaternary structure:
    • Mostly monomeric (By similarity). Interacts with collagen type II.

    Three dimensional structures from OCA and Proteopedia for CHAD Gene

neXtProt entry for CHAD Gene

Post-translational modifications for CHAD Gene

  • Glycosylation at Ser144
  • Modification sites at PhosphoSitePlus

Other Protein References for CHAD Gene

No data available for DME Specific Peptides for CHAD Gene

Domains & Families for CHAD Gene

Gene Families for CHAD Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CHAD Gene

InterPro:
Blocks:
  • Cysteine-rich flanking region, N-terminal
  • Cysteine-rich flanking region, C-terminal

Suggested Antigen Peptide Sequences for CHAD Gene

GenScript: Design optimal peptide antigens:
  • Cartilage leucine-rich protein (CHAD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15335

UniProtKB/Swiss-Prot:

CHAD_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
genes like me logo Genes that share domains with CHAD: view

Function for CHAD Gene

Molecular function for CHAD Gene

UniProtKB/Swiss-Prot Function:
Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).
GENATLAS Biochemistry:
chondroadherin,36kDa,expressed in chodrocytes,leucine-rich repeat (LRR) family

Phenotypes From GWAS Catalog for CHAD Gene

Gene Ontology (GO) - Molecular Function for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with CHAD: view
genes like me logo Genes that share phenotypes with CHAD: view

Animal Models for CHAD Gene

MGI Knock Outs for CHAD:
  • Chad Chad<tm1Gast>

Animal Models for research

  • Taconic Biosciences Mouse Models for CHAD

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHAD

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHAD Gene

Localization for CHAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHAD Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHAD gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0031012 extracellular matrix IBA 21873635
genes like me logo Genes that share ontologies with CHAD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHAD Gene

Pathways & Interactions for CHAD Gene

genes like me logo Genes that share pathways with CHAD: view

Pathways by source for CHAD Gene

Gene Ontology (GO) - Biological Process for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060348 bone development IEA --
GO:1900155 negative regulation of bone trabecula formation IEA --
genes like me logo Genes that share ontologies with CHAD: view

No data available for SIGNOR curated interactions for CHAD Gene

Drugs & Compounds for CHAD Gene

(1) Drugs for CHAD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CHAD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHAD: view

Transcripts for CHAD Gene

mRNA/cDNA for CHAD Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CHAD

Alternative Splicing Database (ASD) splice patterns (SP) for CHAD Gene

No ASD Table

Relevant External Links for CHAD Gene

GeneLoc Exon Structure for
CHAD

Expression for CHAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHAD Gene

mRNA differential expression in normal tissues according to GTEx for CHAD Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.2), Brain - Cerebellum (x5.1), Liver (x5.1), and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for CHAD Gene

This gene is overexpressed in Synovial fluid (36.1), Serum (23.9), and Breast (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHAD Gene



Protein tissue co-expression partners for CHAD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CHAD

SOURCE GeneReport for Unigene cluster for CHAD Gene:

Hs.97220

mRNA Expression by UniProt/SwissProt for CHAD Gene:

O15335-CHAD_HUMAN
Tissue specificity: Present in chondrocytes at all ages.

Evidence on tissue expression from TISSUES for CHAD Gene

  • Nervous system(4.4)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with CHAD: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHAD Gene

Orthologs for CHAD Gene

This gene was present in the common ancestor of animals.

Orthologs for CHAD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CHAD 29 30
  • 99.44 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CHAD 29 30
  • 91.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia CHAD 29 30
  • 90.81 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Chad 29
  • 87.93 (n)
Mouse
(Mus musculus)
Mammalia Chad 29 16 30
  • 87.44 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CHAD 30
  • 87 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CHAD 29 30
  • 71.61 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia CHAD 30
  • 71 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia chad 29
  • 68.84 (n)
Zebrafish
(Danio rerio)
Actinopterygii chad 29 30
  • 64.48 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta haf 30
  • 7 (a)
OneToMany
Species where no ortholog for CHAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CHAD Gene

ENSEMBL:
Gene Tree for CHAD (if available)
TreeFam:
Gene Tree for CHAD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHAD: view image
Alliance of Genome Resources:
Additional Orthologs for CHAD

Paralogs for CHAD Gene

(5) SIMAP similar genes for CHAD Gene using alignment to 2 proteins:

  • CHAD_HUMAN
  • H0YA03_HUMAN
genes like me logo Genes that share paralogs with CHAD: view

Variants for CHAD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CHAD Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs138527449 Benign: not provided 50,465,331(-) G/A
NM_001267.3(CHAD):c.1047C>T (p.Pro349=)
SYNONYMOUS_VARIANT,INTRON
rs142798033 Benign: not provided 50,468,243(-) G/C
NM_001267.3(CHAD):c.571C>G (p.Leu191Val)
MISSENSE_VARIANT,INTRON
rs2231510 Benign: not provided 50,465,329(-) G/Ap.Thr350Ile
NM_001267.3(CHAD):c.1049C>T (p.Thr350Ile)
MISSENSE_VARIANT,INTRON
rs35417848 Benign: not provided 50,468,741(-) G/T
NM_001267.3(CHAD):c.73C>A (p.Gln25Lys)
MISSENSE_VARIANT,INTRON
rs35596951 Benign: not provided 50,468,138(-) G/A
NM_001267.3(CHAD):c.676C>T (p.Leu226=)
SYNONYMOUS_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CHAD Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CHAD Gene

Variant ID Type Subtype PubMed ID
nsv2081 CNV deletion 18451855
nsv833476 CNV loss 17160897
nsv952340 CNV deletion 24416366

Variation tolerance for CHAD Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHAD Gene

Human Gene Mutation Database (HGMD)
CHAD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHAD
Leiden Open Variation Database (LOVD)
CHAD

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHAD Gene

Disorders for CHAD Gene

MalaCards: The human disease database

(2) MalaCards diseases for CHAD Gene - From: COP

Disorder Aliases PubMed IDs
calcific tendinitis
autonomic peripheral neuropathy
  • peripheral autonomic nervous system diseases
- elite association - COSMIC cancer census association via MalaCards
Search CHAD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHAD

genes like me logo Genes that share disorders with CHAD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHAD Gene

Publications for CHAD Gene

  1. The structure and chromosome location of the human chondroadherin gene (CHAD). (PMID: 9344663) Grover J … Roughley PJ (Genomics 1997) 2 3 4 22
  2. Association of chondroadherin with collagen type II. (PMID: 11445564) Mansson B … Heinegård D (The Journal of biological chemistry 2001) 3 4 22
  3. Variation in chondroadherin abundance and fragmentation in the human scoliotic disc. (PMID: 19525844) Haglund L … Roughley P (Spine 2009) 3 22
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Integrin alpha2beta1 is a receptor for the cartilage matrix protein chondroadherin. (PMID: 9281592) Camper L … Lundgren-Akerlund E (The Journal of cell biology 1997) 3 22

Products for CHAD Gene

Sources for CHAD Gene