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Aliases for CHAD Gene

Aliases for CHAD Gene

  • Chondroadherin 2 3 3 5
  • Cartilage Leucine-Rich Protein 3 4
  • Chondroadherin Proteoglycan 2 3
  • SLRR4A 3 4

External Ids for CHAD Gene

Previous GeneCards Identifiers for CHAD Gene

  • GC17M048254
  • GC17M051023
  • GC17M048883
  • GC17M049016
  • GC17M045896
  • GC17M048541
  • GC17M043909

Summaries for CHAD Gene

Entrez Gene Summary for CHAD Gene

  • Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHAD Gene

CHAD (Chondroadherin) is a Protein Coding gene. Diseases associated with CHAD include Lassa Fever. Among its related pathways are Focal Adhesion and PI3K-Akt signaling pathway. An important paralog of this gene is CHADL.

UniProtKB/Swiss-Prot for CHAD Gene

  • Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).

Additional gene information for CHAD Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAD Gene

Genomics for CHAD Gene

GeneHancer (GH) Regulatory Elements for CHAD Gene

Promoters and enhancers for CHAD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J050467 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 658.1 +1.0 959 2.9 ZNF335 GLIS1 MAX ZBTB33 ZIC2 EZH2 ZBTB17 ACSF2 CHAD RSAD1 SPATA20 EPN3 MRPS21P9
GH17J050633 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.6 -169.1 -169071 10.1 PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ABCC3 MBTD1 ENSG00000262837 CHAD MYCBPAP ENSG00000249451 CACNA1G CACNA1G-AS1 SPATA20 LOC105371824
GH17J050171 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.9 +277.4 277359 42 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D COL1A1 SGCA ENSG00000262837 LUC7L3 FLJ45513 TMEM92-AS1 TMEM92 XYLT2 PPP1R9B ENSG00000253730
GH17J050423 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.7 +42.9 42888 6.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ACSF2 MBTD1 ENSG00000262837 UTP18 RSAD1 XYLT2 CHAD FAM117A ENSG00000253102 LRRC59
GH17J050507 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.9 -40.1 -40147 5 HDGF PKNOX1 ATF1 SIN3A BATF IRF4 ZNF121 ZNF143 ATF7 RCOR1 MYCBPAP ENSG00000249451 EPN3 RSAD1 ACSF2 LOC105371824 SPATA20 CACNA1G CACNA1G-AS1 CHAD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHAD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHAD gene promoter:

Genomic Locations for CHAD Gene

Genomic Locations for CHAD Gene
chr17:50,464,492-50,469,881
(GRCh38/hg38)
Size:
5,390 bases
Orientation:
Minus strand
chr17:48,541,853-48,546,327
(GRCh37/hg19)

Genomic View for CHAD Gene

Genes around CHAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAD Gene

Proteins for CHAD Gene

  • Protein details for CHAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15335-CHAD_HUMAN
    Recommended name:
    Chondroadherin
    Protein Accession:
    O15335
    Secondary Accessions:
    • A8K812
    • Q6GTU0
    • Q96RJ5

    Protein attributes for CHAD Gene

    Size:
    359 amino acids
    Molecular mass:
    40476 Da
    Quaternary structure:
    • Mostly monomeric (By similarity). Interacts with collagen type II.

    Three dimensional structures from OCA and Proteopedia for CHAD Gene

neXtProt entry for CHAD Gene

Post-translational modifications for CHAD Gene

  • Glycosylation at posLast=144144
  • Modification sites at PhosphoSitePlus

Other Protein References for CHAD Gene

No data available for DME Specific Peptides for CHAD Gene

Domains & Families for CHAD Gene

Gene Families for CHAD Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CHAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15335

UniProtKB/Swiss-Prot:

CHAD_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
genes like me logo Genes that share domains with CHAD: view

Function for CHAD Gene

Molecular function for CHAD Gene

UniProtKB/Swiss-Prot Function:
Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).
GENATLAS Biochemistry:
chondroadherin,36kDa,expressed in chodrocytes,leucine-rich repeat (LRR) family

Phenotypes From GWAS Catalog for CHAD Gene

Gene Ontology (GO) - Molecular Function for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with CHAD: view
genes like me logo Genes that share phenotypes with CHAD: view

Animal Models for CHAD Gene

MGI Knock Outs for CHAD:
  • Chad Chad<tm1Gast>

Animal Model Products

  • Taconic Biosciences Mouse Models for CHAD

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHAD Gene

Localization for CHAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHAD Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHAD gene
Compartment Confidence
extracellular 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CHAD: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHAD Gene

Pathways & Interactions for CHAD Gene

genes like me logo Genes that share pathways with CHAD: view

Pathways by source for CHAD Gene

Gene Ontology (GO) - Biological Process for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0046426 negative regulation of JAK-STAT cascade IBA --
GO:0060348 bone development IEA --
GO:1900155 negative regulation of bone trabecula formation IEA --
genes like me logo Genes that share ontologies with CHAD: view

No data available for SIGNOR curated interactions for CHAD Gene

Drugs & Compounds for CHAD Gene

(1) Drugs for CHAD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CHAD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHAD: view

Transcripts for CHAD Gene

mRNA/cDNA for CHAD Gene

(65) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHAD Gene

Chondroadherin:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHAD Gene

No ASD Table

Relevant External Links for CHAD Gene

GeneLoc Exon Structure for
CHAD
ECgene alternative splicing isoforms for
CHAD

Expression for CHAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHAD Gene

mRNA differential expression in normal tissues according to GTEx for CHAD Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.2), Brain - Cerebellum (x5.1), Liver (x5.1), and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for CHAD Gene

This gene is overexpressed in Synovial fluid (36.1), Serum (23.9), and Breast (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHAD Gene



Protein tissue co-expression partners for CHAD Gene

NURSA nuclear receptor signaling pathways regulating expression of CHAD Gene:

CHAD

SOURCE GeneReport for Unigene cluster for CHAD Gene:

Hs.97220

mRNA Expression by UniProt/SwissProt for CHAD Gene:

O15335-CHAD_HUMAN
Tissue specificity: Present in chondrocytes at all ages.

Evidence on tissue expression from TISSUES for CHAD Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with CHAD: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHAD Gene

Orthologs for CHAD Gene

This gene was present in the common ancestor of animals.

Orthologs for CHAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHAD 34 33
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CHAD 34 33
  • 91.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CHAD 34 33
  • 90.81 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chad 33
  • 87.93 (n)
mouse
(Mus musculus)
Mammalia Chad 16 34 33
  • 87.44 (n)
oppossum
(Monodelphis domestica)
Mammalia CHAD 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHAD 34 33
  • 71.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHAD 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chad 33
  • 68.84 (n)
zebrafish
(Danio rerio)
Actinopterygii chad 34 33
  • 64.48 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta haf 34
  • 7 (a)
OneToMany
Species where no ortholog for CHAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHAD Gene

ENSEMBL:
Gene Tree for CHAD (if available)
TreeFam:
Gene Tree for CHAD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHAD: view image

Paralogs for CHAD Gene

(5) SIMAP similar genes for CHAD Gene using alignment to 2 proteins:

  • CHAD_HUMAN
  • H0YA03_HUMAN
genes like me logo Genes that share paralogs with CHAD: view

Variants for CHAD Gene

Sequence variations from dbSNP and Humsavar for CHAD Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000702588 -- 50,467,835(-) G/A intron_variant
rs1000776012 -- 50,469,192(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000954982 -- 50,471,533(-) T/G upstream_transcript_variant
rs1001398855 -- 50,469,108(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1002850262 -- 50,467,405(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHAD Gene

Variant ID Type Subtype PubMed ID
nsv2081 CNV deletion 18451855
nsv833476 CNV loss 17160897
nsv952340 CNV deletion 24416366

Variation tolerance for CHAD Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHAD Gene

Human Gene Mutation Database (HGMD)
CHAD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHAD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHAD Gene

Disorders for CHAD Gene

MalaCards: The human disease database

(1) MalaCards diseases for CHAD Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
lassa fever
  • lf
- elite association - COSMIC cancer census association via MalaCards
Search CHAD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CHAD

genes like me logo Genes that share disorders with CHAD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHAD Gene

Publications for CHAD Gene

  1. The structure and chromosome location of the human chondroadherin gene (CHAD). (PMID: 9344663) Grover J … Roughley PJ (Genomics 1997) 2 3 4 22 58
  2. Association of chondroadherin with collagen type II. (PMID: 11445564) Mansson B … Heinegård D (The Journal of biological chemistry 2001) 3 4 22 58
  3. Variation in chondroadherin abundance and fragmentation in the human scoliotic disc. (PMID: 19525844) Haglund L … Roughley P (Spine 2009) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Integrin alpha2beta1 is a receptor for the cartilage matrix protein chondroadherin. (PMID: 9281592) Camper L … Lundgren-Akerlund E (The Journal of cell biology 1997) 3 22 58

Products for CHAD Gene

Sources for CHAD Gene

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