Aliases for CHAC2 Gene
External Ids for CHAC2 Gene
Previous GeneCards Identifiers for CHAC2 Gene
The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]
GeneCards Summary for CHAC2 Gene
CHAC2 (ChaC Cation Transport Regulator Homolog 2) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is CHAC1.
UniProtKB/Swiss-Prot for CHAC2 Gene
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.