Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHAC2 Gene

Aliases for CHAC2 Gene

  • ChaC Cation Transport Regulator Homolog 2 2 3 5
  • Cation Transport Regulator-Like Protein 2 3 4
  • Gamma-GCT Acting On Glutathione Homolog 2 2 3
  • Gamma-GCG 2 3 4
  • Putative Glutathione-Specific Gamma-Glutamylcyclotransferase 2 3
  • Glutathione-Specific Gamma-Glutamylcyclotransferase 2 3
  • ChaC, Cation Transport Regulator Homolog 2 (E. Coli) 2
  • ChaC, Cation Transport Regulator-Like 2 (E. Coli) 2
  • ChaC, Cation Transport Regulator-Like 2 3
  • EC 4.3.2.7 4
  • GCG1 3

External Ids for CHAC2 Gene

Previous GeneCards Identifiers for CHAC2 Gene

  • GC02U900806
  • GC02P053848
  • GC02P053994
  • GC02P053729

Summaries for CHAC2 Gene

Entrez Gene Summary for CHAC2 Gene

  • The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]

GeneCards Summary for CHAC2 Gene

CHAC2 (ChaC Cation Transport Regulator Homolog 2) is a Protein Coding gene. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is CHAC1.

UniProtKB/Swiss-Prot for CHAC2 Gene

  • Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

Additional gene information for CHAC2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAC2 Gene

Genomics for CHAC2 Gene

GeneHancer (GH) Regulatory Elements for CHAC2 Gene

Promoters and enhancers for CHAC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J053766 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.2 204 2.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 CHAC2 ACYP2 ASB3 ERLEC1 GC02P053747 GPR75-ASB3
GH02J053738 Promoter/Enhancer 0.9 EPDnew FANTOM5 650.3 -28.7 -28678 0.4 HNF4A CHAC2 GPR75 PSME4 GC02P053747 ASB3 GC02M053662 GPR75-ASB3
GH02J053769 Enhancer 0.7 ENCODE 650.7 +1.7 1674 0 BCOR HDAC1 MEIS2 PKNOX1 ZNF316 POLR2A ZSCAN29 NFE2 MAFK L3MBTL2 CHAC2 ACYP2 ASB3 ERLEC1 GC02P053747 GPR75-ASB3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHAC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CHAC2 gene promoter:

Genomic Locations for CHAC2 Gene

Genomic Locations for CHAC2 Gene
chr2:53,767,792-53,775,196
(GRCh38/hg38)
Size:
7,405 bases
Orientation:
Plus strand
chr2:53,994,929-54,002,333
(GRCh37/hg19)

Genomic View for CHAC2 Gene

Genes around CHAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAC2 Gene

Proteins for CHAC2 Gene

  • Protein details for CHAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUX2-CHAC2_HUMAN
    Recommended name:
    Glutathione-specific gamma-glutamylcyclotransferase 2
    Protein Accession:
    Q8WUX2
    Secondary Accessions:
    • Q8WVI8

    Protein attributes for CHAC2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20875 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for CHAC2 Gene

Post-translational modifications for CHAC2 Gene

  • Ubiquitination at posLast=178178
  • Modification sites at PhosphoSitePlus

Other Protein References for CHAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHAC2 Gene

Domains & Families for CHAC2 Gene

Gene Families for CHAC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CHAC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUX2

UniProtKB/Swiss-Prot:

CHAC2_HUMAN :
  • Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
Family:
  • Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
genes like me logo Genes that share domains with CHAC2: view

Function for CHAC2 Gene

Molecular function for CHAC2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione = L-cysteinylglycine + 5-oxo-L-proline.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.7 mM for glutathione {ECO:0000269 PubMed:27913623}; Note=kcat is 15.9 min(-1) for glutathione. {ECO:0000269 PubMed:27913623};

Enzyme Numbers (IUBMB) for CHAC2 Gene

Gene Ontology (GO) - Molecular Function for CHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003839 gamma-glutamylcyclotransferase activity IBA,TAS --
GO:0016829 lyase activity IEA --
GO:0061928 glutathione specific gamma-glutamylcyclotransferase activity IEA --
genes like me logo Genes that share ontologies with CHAC2: view
genes like me logo Genes that share phenotypes with CHAC2: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHAC2 Gene

Localization for CHAC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHAC2 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHAC2 gene
Compartment Confidence
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHAC2: view

Pathways & Interactions for CHAC2 Gene

genes like me logo Genes that share pathways with CHAC2: view

Pathways by source for CHAC2 Gene

Gene Ontology (GO) - Biological Process for CHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006750 glutathione biosynthetic process TAS --
GO:0006751 glutathione catabolic process IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CHAC2: view

No data available for SIGNOR curated interactions for CHAC2 Gene

Drugs & Compounds for CHAC2 Gene

No Compound Related Data Available

Transcripts for CHAC2 Gene

mRNA/cDNA for CHAC2 Gene

(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHAC2 Gene

ChaC, cation transport regulator homolog 2 (E. coli):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHAC2 Gene

No ASD Table

Relevant External Links for CHAC2 Gene

GeneLoc Exon Structure for
CHAC2
ECgene alternative splicing isoforms for
CHAC2

Expression for CHAC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHAC2 Gene

Protein differential expression in normal tissues from HIPED for CHAC2 Gene

This gene is overexpressed in Testis (33.4), Retina (13.4), Fetal Liver (10.2), and Tonsil (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CHAC2 Gene



Protein tissue co-expression partners for CHAC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHAC2 Gene:

CHAC2

SOURCE GeneReport for Unigene cluster for CHAC2 Gene:

Hs.585944

Evidence on tissue expression from TISSUES for CHAC2 Gene

  • Nervous system(4.2)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with CHAC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHAC2 Gene

Orthologs for CHAC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHAC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHAC2 34 33
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CHAC2 34 33
  • 95.47 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CHAC2 34 33
  • 92.64 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chac2 33
  • 91.95 (n)
mouse
(Mus musculus)
Mammalia Chac2 16 34 33
  • 91.76 (n)
oppossum
(Monodelphis domestica)
Mammalia CHAC2 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHAC2 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHAC2 34 33
  • 78.49 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHAC2 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chac2 33
  • 79.71 (n)
zebrafish
(Danio rerio)
Actinopterygii chac2 34 33
  • 67.05 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002216 33
  • 53.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2540 34 33
  • 52.05 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCG1 36 33
  • 49.46 (n)
-- 34
  • 30 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR184C 33
  • 47.62 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11649g 33
  • 47.29 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G44790 33
  • 52.06 (n)
rice
(Oryza sativa)
Liliopsida Os04g0448600 33
  • 57.95 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 60 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU02737 33
  • 48.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC31F10.03 33
  • 48.19 (n)
Species where no ortholog for CHAC2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHAC2 Gene

ENSEMBL:
Gene Tree for CHAC2 (if available)
TreeFam:
Gene Tree for CHAC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CHAC2: view image

Paralogs for CHAC2 Gene

Paralogs for CHAC2 Gene

(1) SIMAP similar genes for CHAC2 Gene using alignment to 1 proteins:

  • CHAC2_HUMAN
genes like me logo Genes that share paralogs with CHAC2: view

Variants for CHAC2 Gene

Sequence variations from dbSNP and Humsavar for CHAC2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000131331 -- 53,772,668(+) T/C intron_variant
rs1000468676 -- 53,770,002(+) C/A intron_variant
rs1000797367 -- 53,770,272(+) A/G intron_variant
rs1001547970 -- 53,775,382(+) T/A downstream_transcript_variant
rs1002333226 -- 53,768,882(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHAC2 Gene

Variant ID Type Subtype PubMed ID
nsv1009829 CNV loss 25217958
nsv834058 CNV gain+loss 17160897

Variation tolerance for CHAC2 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHAC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHAC2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHAC2 Gene

Disorders for CHAC2 Gene

Additional Disease Information for CHAC2

No disorders were found for CHAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHAC2 Gene

Publications for CHAC2 Gene

  1. ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione. (PMID: 27913623) Kaur A … Bachhawat AK (The Journal of biological chemistry 2017) 2 3 4 58
  2. Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. (PMID: 23070364) Kumar A … Bachhawat AK (EMBO reports 2012) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for CHAC2 Gene

Sources for CHAC2 Gene

Content
Loading form....