Aliases for CHAC1 Gene
External Ids for CHAC1 Gene
Previous GeneCards Identifiers for CHAC1 Gene
This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016]
GeneCards Summary for CHAC1 Gene
CHAC1 (ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1) is a Protein Coding gene. Diseases associated with CHAC1 include Locked-In Syndrome. Among its related pathways are Cytochrome P450 - arranged by substrate type and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring acyl groups and Notch binding. An important paralog of this gene is CHAC2.
UniProtKB/Swiss-Prot Summary for CHAC1 Gene
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).