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Aliases for CGRRF1 Gene

Aliases for CGRRF1 Gene

  • Cell Growth Regulator With Ring Finger Domain 1 2 3 5
  • Cell Growth Regulatory Gene 19 Protein 3 4
  • RING Finger Protein 197 3 4
  • RNF197 3 4
  • CGR19 3 4
  • Cell Growth Regulator With RING Finger Domain Protein 1 3

External Ids for CGRRF1 Gene

Previous GeneCards Identifiers for CGRRF1 Gene

  • GC14P052966
  • GC14P054046
  • GC14P054976
  • GC14P035139

Summaries for CGRRF1 Gene

GeneCards Summary for CGRRF1 Gene

CGRRF1 (Cell Growth Regulator With Ring Finger Domain 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CGRRF1 Gene

  • Able to inhibit growth in several cell lines.

Additional gene information for CGRRF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGRRF1 Gene

Genomics for CGRRF1 Gene

GeneHancer (GH) Regulatory Elements for CGRRF1 Gene

Promoters and enhancers for CGRRF1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I054509 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.3 258 1.7 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 SP3 CGRRF1 CNIH1 GC14P054543 GC14P054145
GH14I054487 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 -20.4 -20373 3.8 HDGF PKNOX1 CLOCK ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF207 GMFB ATG14 BMP4 MAPK1IP1L SOCS4 ENSG00000259318 CGRRF1 CNIH1 WDHD1 GC14P054145
GH14I054818 Enhancer 0.9 ENCODE 20.8 +308.9 308926 1.4 FEZF1 ZNF2 ZNF213 FOS TSHZ1 ZNF518A ZNF585B KDM1A PRDM4 WT1 CGRRF1 GCH1 RNU6ATAC9P ATG14 PIR45415 GC14P054860
GH14I054711 Enhancer 0.8 Ensembl ENCODE dbSUPER 20.2 +202.9 202946 2.8 ZNF529 NFE2 RUNX3 CGRRF1 SAMD4A GCH1 LOC729451 PIR45415 GC14P054145
GH14I054648 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.9 +142.1 142087 7.4 FOXA2 ARID4B SIN3A ETS1 ATF7 FOS RXRA SP5 REST PPARG CGRRF1 SAMD4A LOC729451 GC14P054145
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CGRRF1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CGRRF1 gene promoter:

Genomic Locations for CGRRF1 Gene

Genomic Locations for CGRRF1 Gene
chr14:54,509,812-54,539,309
(GRCh38/hg38)
Size:
29,498 bases
Orientation:
Plus strand
chr14:54,976,530-55,005,567
(GRCh37/hg19)

Genomic View for CGRRF1 Gene

Genes around CGRRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGRRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGRRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGRRF1 Gene

Proteins for CGRRF1 Gene

  • Protein details for CGRRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99675-CGRF1_HUMAN
    Recommended name:
    Cell growth regulator with RING finger domain protein 1
    Protein Accession:
    Q99675
    Secondary Accessions:
    • Q96BX2

    Protein attributes for CGRRF1 Gene

    Size:
    332 amino acids
    Molecular mass:
    38242 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CGRRF1 Gene

neXtProt entry for CGRRF1 Gene

Post-translational modifications for CGRRF1 Gene

No Post-translational modifications

Other Protein References for CGRRF1 Gene

No data available for DME Specific Peptides for CGRRF1 Gene

Domains & Families for CGRRF1 Gene

Gene Families for CGRRF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CGRRF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CGRRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CGRRF1: view

No data available for UniProtKB/Swiss-Prot for CGRRF1 Gene

Function for CGRRF1 Gene

Molecular function for CGRRF1 Gene

UniProtKB/Swiss-Prot Function:
Able to inhibit growth in several cell lines.
UniProtKB/Swiss-Prot Induction:
Up-regulated by endoplasmic reticulum (ER) stress triggered by thapsigargin or tunicamycin.

Phenotypes From GWAS Catalog for CGRRF1 Gene

Gene Ontology (GO) - Molecular Function for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CGRRF1: view
genes like me logo Genes that share phenotypes with CGRRF1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGRRF1 Gene

Localization for CGRRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGRRF1 Gene

Nucleus. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGRRF1 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 4
extracellular 3
plasma membrane 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CGRRF1: view

Pathways & Interactions for CGRRF1 Gene

SuperPathways for CGRRF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 8968090
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
GO:0008285 negative regulation of cell proliferation TAS 8968090
genes like me logo Genes that share ontologies with CGRRF1: view

No data available for Pathways by source and SIGNOR curated interactions for CGRRF1 Gene

Drugs & Compounds for CGRRF1 Gene

No Compound Related Data Available

Transcripts for CGRRF1 Gene

Unigene Clusters for CGRRF1 Gene

Cell growth regulator with ring finger domain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGRRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - - -
SP12: - -
SP13:
SP14:

Relevant External Links for CGRRF1 Gene

GeneLoc Exon Structure for
CGRRF1
ECgene alternative splicing isoforms for
CGRRF1

Expression for CGRRF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CGRRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CGRRF1 Gene:

CGRRF1

SOURCE GeneReport for Unigene cluster for CGRRF1 Gene:

Hs.59106

mRNA Expression by UniProt/SwissProt for CGRRF1 Gene:

Q99675-CGRF1_HUMAN
Tissue specificity: Ubiquitously expressed with high expression in testis and the cerebellum.

Evidence on tissue expression from TISSUES for CGRRF1 Gene

  • Nervous system(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with CGRRF1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGRRF1 Gene

Orthologs for CGRRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGRRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGRRF1 33 34
  • 99.9 (n)
cow
(Bos Taurus)
Mammalia CGRRF1 33 34
  • 93.78 (n)
dog
(Canis familiaris)
Mammalia CGRRF1 33 34
  • 93.07 (n)
mouse
(Mus musculus)
Mammalia Cgrrf1 33 16 34
  • 84.4 (n)
rat
(Rattus norvegicus)
Mammalia Cgrrf1 33
  • 82.87 (n)
oppossum
(Monodelphis domestica)
Mammalia CGRRF1 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CGRRF1 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CGRRF1 33 34
  • 77.44 (n)
lizard
(Anolis carolinensis)
Reptilia CGRRF1 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cgrrf1 33
  • 69.54 (n)
zebrafish
(Danio rerio)
Actinopterygii cgrrf1 33 34
  • 56.98 (n)
Species where no ortholog for CGRRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGRRF1 Gene

ENSEMBL:
Gene Tree for CGRRF1 (if available)
TreeFam:
Gene Tree for CGRRF1 (if available)

Paralogs for CGRRF1 Gene

(6) SIMAP similar genes for CGRRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CGRRF1: view

No data available for Paralogs for CGRRF1 Gene

Variants for CGRRF1 Gene

Sequence variations from dbSNP and Humsavar for CGRRF1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000008891 -- 54,521,219(+) G/T intron_variant
rs1000216724 -- 54,514,836(+) C/A intron_variant
rs1000299173 -- 54,527,369(+) A/T intron_variant
rs1000467493 -- 54,535,684(+) C/G intron_variant
rs1000487878 -- 54,509,278(+) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CGRRF1 Gene

Variant ID Type Subtype PubMed ID
nsv832802 CNV loss 17160897
esv3551581 CNV deletion 23714750

Variation tolerance for CGRRF1 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGRRF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGRRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGRRF1 Gene

Disorders for CGRRF1 Gene

Additional Disease Information for CGRRF1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CGRRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CGRRF1 Gene

Publications for CGRRF1 Gene

  1. Induction of cell growth regulatory genes by p53. (PMID: 8968090) Madden SL … Beaudry GA (Cancer research 1996) 2 3 4 58
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58

Products for CGRRF1 Gene

Sources for CGRRF1 Gene

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