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This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
CGB8 (Chorionic Gonadotropin Subunit Beta 8) is a Protein Coding gene. Diseases associated with CGB8 include Tinea Favosa and Mixed Ductal-Endocrine Carcinoma. Among its related pathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and Gene Expression. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CGB3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | -- |
GO:0005737 | cytoplasm | IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide hormone metabolism | ||
2 | Gene Expression |
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3 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | ||
4 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | -- |
GO:0006915 | apoptotic process | TAS | -- |
GO:0007165 | signal transduction | TAS | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | -- |
GO:0007267 | cell-cell signaling | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Luteinizing hormone releasing hormone human acetate salt (LHRH) | Pharma | 0 |
Compound | Action | Cas Number |
---|---|---|
Luteinizing hormone releasing hormone human acetate salt (LHRH) | 71447-49-9 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | LHB 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | LHB 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Lhb 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | LHB 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | lhb 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
tinea favosa |
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mixed ductal-endocrine carcinoma |
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cryptococcosis |
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fungal meningitis |
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