This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the stero... See more...

Aliases for CGB8 Gene

Aliases for CGB8 Gene

  • Chorionic Gonadotropin Subunit Beta 8 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 8 2 3
  • Chorionic Gonadotropin Beta Subunit 8 2 3
  • Chorionic Gonadotropin Beta 8 Subunit 3
  • Choriogonadotropin Subunit Beta 3 4
  • Chorionic Gonadotropin Chain Beta 4
  • Choriogonadotropin Subunit Beta 4
  • CG-Beta 4
  • CGB8 5
  • CGB 4

External Ids for CGB8 Gene

Previous GeneCards Identifiers for CGB8 Gene

  • GC19M050210
  • GC19M049919
  • GC19M054226
  • GC19M054243
  • GC19M054245
  • GC19M054247
  • GC19M054227
  • GC19M054228
  • GC19M054229
  • GC19M054248
  • GC19M049550
  • GC19M045927

Summaries for CGB8 Gene

Entrez Gene Summary for CGB8 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB8 Gene

CGB8 (Chorionic Gonadotropin Subunit Beta 8) is a Protein Coding gene. Diseases associated with CGB8 include Mixed Ductal-Endocrine Carcinoma and Patellofemoral Pain Syndrome. Among its related pathways are Peptide hormone metabolism and Gene Expression. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CGB3.

UniProtKB/Swiss-Prot Summary for CGB8 Gene

  • Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CGB8 Gene

Genomics for CGB8 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CGB8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049050 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 261.2 -1.3 -1290 1.2 ZIC2 JUND ZBTB21 BHLHE40 KLF1 ZFP3 ZNF629 PATZ1 ZBTB33 GLIS2 CGB8 ENSG00000269706 LOC100287489 lnc-CGB8-1 KCNA7 CGB2 CGB7 HSALNG0126944
GH19J049049 Promoter 0.3 EPDnew 250.7 0.0 -10 0.1 CGB8 ENSG00000269706 LOC100287489 lnc-CGB8-1 KCNA7 CGB7 HSALNG0126944
GH19J049055 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 53.7 -7.7 -7724 2.7 ZIC2 MNT KLF7 CTCF KLF9 ZNF610 SMAD4 SP2 SAP130 GABPB1 ENSG00000283251 lnc-NTF4-2 lnc-NTF4-3 CGB8 NTF4 CGB7 ENSG00000283663 LOC100287489
GH19J049113 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 13.4 -67.8 -67792 7 BCLAF1 SP1 MYC ZNF207 NCOR1 IKZF1 SIX5 JUND ZNF580 ZNF592 LIN7B PPFIA3 SNRNP70 IRF3 NUP62 PRR12 NTF4 PTOV1 PTOV1-AS2 SNORD35A
GH19J049058 Enhancer 0.5 CraniofacialAtlas 46.9 -9.4 -9433 0.4 ZIC2 SP2 RFX1 SP1 PKNOX1 BMI1 CGB7 ENSG00000283251 lnc-NTF4-2 lnc-NTF4-3 CGB8 ENSG00000283663 NTF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGB8 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CGB8

Top Transcription factor binding sites by QIAGEN in the CGB8 gene promoter:
  • Egr-4
  • NF-1
  • NF-1/L
  • p53
  • Pax-5
  • POU3F1

Genomic Locations for CGB8 Gene

Latest Assembly
chr19:49,047,638-49,049,111
(GRCh38/hg38)
Size:
1,474 bases
Orientation:
Minus strand

Previous Assembly
chr19:49,550,895-49,552,368
(GRCh37/hg19 by Entrez Gene)
Size:
1,474 bases
Orientation:
Minus strand

chr19:49,550,895-49,552,400
(GRCh37/hg19 by Ensembl)
Size:
1,506 bases
Orientation:
Minus strand

Genomic View for CGB8 Gene

Genes around CGB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB8 Gene

Proteins for CGB8 Gene

  • Protein details for CGB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN86-CGB3_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta 3
    Protein Accession:
    P0DN86
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • P01233
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB8 Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.

    Three dimensional structures from OCA and Proteopedia for CGB8 Gene

    Alternative splice isoforms for CGB8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB8 Gene

Post-translational modifications for CGB8 Gene

  • Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CGB3_HUMAN (88, 91)

Other Protein References for CGB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB8 Gene

Domains & Families for CGB8 Gene

Gene Families for CGB8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CGB8 Gene

GenScript: Design optimal peptide antigens:
  • Chorionic gonadotrophin chain beta (CGHB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P0DN86

UniProtKB/Swiss-Prot:

CGB3_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB8: view

Function for CGB8 Gene

Molecular function for CGB8 Gene

UniProtKB/Swiss-Prot Function:
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Phenotypes From GWAS Catalog for CGB8 Gene

Gene Ontology (GO) - Molecular Function for CGB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with CGB8: view
genes like me logo Genes that share phenotypes with CGB8: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB8 Gene

Localization for CGB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB8 gene
Compartment Confidence
extracellular 5
cytosol 3
plasma membrane 2
nucleus 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CGB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CGB8: view

Pathways & Interactions for CGB8 Gene

genes like me logo Genes that share pathways with CGB8: view

Interacting Proteins for CGB8 Gene

Gene Ontology (GO) - Biological Process for CGB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II TAS --
GO:0006915 apoptotic process TAS --
GO:0007165 signal transduction TAS --
GO:0007186 G protein-coupled receptor signaling pathway IBA --
GO:0007267 cell-cell signaling TAS --
genes like me logo Genes that share ontologies with CGB8: view

No data available for SIGNOR curated interactions for CGB8 Gene

Drugs & Compounds for CGB8 Gene

(1) Drugs for CGB8 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Luteinizing hormone releasing hormone human acetate salt (LHRH) Pharma 0

(1) ApexBio Compounds for CGB8 Gene

genes like me logo Genes that share compounds with CGB8: view

Drug products for research

Transcripts for CGB8 Gene

mRNA/cDNA for CGB8 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB8

Alternative Splicing Database (ASD) splice patterns (SP) for CGB8 Gene

No ASD Table

Relevant External Links for CGB8 Gene

GeneLoc Exon Structure for
CGB8

Expression for CGB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CGB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CGB8

mRNA Expression by UniProt/SwissProt for CGB8 Gene:

P0DN86-CGB3_HUMAN
Tissue specificity: High expression in the placenta throughout pregnancy.

Evidence on tissue expression from TISSUES for CGB8 Gene

  • Nervous system(4.4)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with CGB8: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB8 Gene

Orthologs for CGB8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB8 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 97 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LHB 30
  • 65 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LHB 30
  • 64 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Lhb 30
  • 62 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia LHB 30
  • 55 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 36 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii lhb 30
  • 39 (a)
OneToMany
Species where no ortholog for CGB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CGB8 Gene

ENSEMBL:
Gene Tree for CGB8 (if available)
TreeFam:
Gene Tree for CGB8 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CGB8: view image
Alliance of Genome Resources:
Additional Orthologs for CGB8

Paralogs for CGB8 Gene

Paralogs for CGB8 Gene

(8) SIMAP similar genes for CGB8 Gene using alignment to 2 proteins:

  • CGHB_HUMAN
  • J3KNZ1_HUMAN
genes like me logo Genes that share paralogs with CGB8: view

Variants for CGB8 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CGB8 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CGB8 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495
nsv978832 CNV duplication 23825009

Variation tolerance for CGB8 Gene

Gene Damage Index Score: 0.09; 2.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB8
Leiden Open Variation Database (LOVD)
CGB8

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CGB8 Gene

Disorders for CGB8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CGB8 Gene - From: COP

Disorder Aliases PubMed IDs
mixed ductal-endocrine carcinoma
patellofemoral pain syndrome
gestational trophoblastic neoplasm
  • gestational trophoblastic neoplasia
- elite association - COSMIC cancer census association via MalaCards
Search CGB8 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CGB8

genes like me logo Genes that share disorders with CGB8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB8 Gene

Publications for CGB8 Gene

  1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The Journal of biological chemistry 1983) 2 3 4
  2. A map of the hCG beta-LH beta gene cluster. (PMID: 2422163) Policastro PF … Boime I (The Journal of biological chemistry 1986) 3 4
  3. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PMID: 6690982) Talmadge K … Fiddes JC (Nature 1984) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes. (PMID: 18606016) Hallast P … Laan M (BMC evolutionary biology 2008) 22

Products for CGB8 Gene

Sources for CGB8 Gene