This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the stero... See more...

Aliases for CGB7 Gene

Aliases for CGB7 Gene

  • Chorionic Gonadotropin Subunit Beta 7 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 7 2 3
  • Chorionic Gonadotropin Beta Subunit 7 2 3
  • Choriogonadotropin Subunit Beta 7 3 4
  • CG-Beta-A 2 3
  • Chorionic Gonadotropin Beta 7 Subunit 3
  • CGB6 3
  • CGB7 5

External Ids for CGB7 Gene

Previous GeneCards Identifiers for CGB7 Gene

  • GC19M050215
  • GC19M049920
  • GC19M054233
  • GC19M054242
  • GC19M054249
  • GC19M049557
  • GC19M045934

Summaries for CGB7 Gene

Entrez Gene Summary for CGB7 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB7 Gene

CGB7 (Chorionic Gonadotropin Subunit Beta 7) is a Protein Coding gene. Diseases associated with CGB7 include Ectopic Pregnancy and Trisomy 22. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CGB3.

UniProtKB/Swiss-Prot Summary for CGB7 Gene

  • Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Gene Wiki entry for CGB7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CGB7 Gene

Genomics for CGB7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CGB7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049058 Enhancer 0.5 CraniofacialAtlas 600.7 +0.3 316 0.4 RFX1 ZIC2 SP2 SP1 BMI1 PKNOX1 CGB7 ENSG00000283251 lnc-NTF4-2 lnc-NTF4-3 CGB8 ENSG00000283663 NTF4
GH19J048988 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.6 +66.8 66807 7.2 CEBPG SP1 CREB1 GATAD2A CTCF PRDM10 ZNF629 TFE3 IKZF1 ZNF692 RUVBL2 GYS1 lnc-LHB-2 NUP62 GRWD1 PTOV1-AS2 SNORD35A IRF3 SNORD35B SNRNP70
GH19J049113 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 -56.0 -56043 3 SP1 GATAD2A CTCF PRDM10 TFE3 SIX5 ZNF692 POLR2A BACH1 TARDBP LIN7B CGB8 SNRNP70 NTF4 CGB7 KCNA7 C19orf73
GH19J049142 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -83.9 -83912 1.7 SP1 CREB1 PRDM10 ZNF512 DDX20 MTA2 PKNOX1 POLR2A PATZ1 ZNF341 PPFIA3 C19orf73 LIN7B SNRNP70 NTF4 CGB7 KCNA7 SLC6A16 CD37 KASH5
GH19J049038 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 17.8 +20.1 20059 1.6 PRDM10 ZNF629 IKZF1 ZIC2 CREB1 FOSL1 FOSL2 SIN3A DPF2 ZFP3 CGB1 ENSG00000267335 NTF6B SNAR-G1 CGB7 NTF4 CGB2 RUVBL2 CGB5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGB7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CGB7

Top Transcription factor binding sites by QIAGEN in the CGB7 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CP1A
  • Egr-4
  • NF-Y
  • NF-YA
  • NF-YB
  • p53
  • Pax-5

Genomic Locations for CGB7 Gene

Genomic Locations for CGB7 Gene
chr19:49,054,274-49,058,860
(GRCh38/hg38)
Size:
4,587 bases
Orientation:
Minus strand
chr19:49,557,531-49,562,117
(GRCh37/hg19)
Size:
4,587 bases
Orientation:
Minus strand

Genomic View for CGB7 Gene

Genes around CGB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB7 Gene

Proteins for CGB7 Gene

  • Protein details for CGB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN87-CGB7_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta 7
    Protein Accession:
    P0DN87
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • P01233
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB7 Gene

    Size:
    165 amino acids
    Molecular mass:
    17757 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones and confers receptor and biological specificity.
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.

neXtProt entry for CGB7 Gene

Post-translational modifications for CGB7 Gene

  • Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158

Other Protein References for CGB7 Gene

No data available for DME Specific Peptides for CGB7 Gene

Domains & Families for CGB7 Gene

Gene Families for CGB7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CGB7 Gene

Graphical View of Domain Structure for InterPro Entry

P0DN87

UniProtKB/Swiss-Prot:

CGB7_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB7: view

No data available for Suggested Antigen Peptide Sequences for CGB7 Gene

Function for CGB7 Gene

Molecular function for CGB7 Gene

UniProtKB/Swiss-Prot Function:
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Phenotypes From GWAS Catalog for CGB7 Gene

Gene Ontology (GO) - Molecular Function for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 contributes_to hormone activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with CGB7: view
genes like me logo Genes that share phenotypes with CGB7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB7 Gene

Localization for CGB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB7 gene
Compartment Confidence
extracellular 4
cytosol 3
plasma membrane 2
nucleus 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CGB7: view

Pathways & Interactions for CGB7 Gene

PathCards logo

SuperPathways for CGB7 Gene

No Data Available

Interacting Proteins for CGB7 Gene

Gene Ontology (GO) - Biological Process for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7723844
GO:0007165 signal transduction TAS 10468638
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007267 cell-cell signaling TAS 6194155
GO:0007292 female gamete generation TAS 10468638
genes like me logo Genes that share ontologies with CGB7: view

No data available for Pathways by source and SIGNOR curated interactions for CGB7 Gene

Drugs & Compounds for CGB7 Gene

(10) Drugs for CGB7 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Luteinizing hormone releasing hormone human acetate salt (LHRH) Pharma 0

(5) Additional Compounds for CGB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CGB7 Gene

genes like me logo Genes that share compounds with CGB7: view

Drug Products

Transcripts for CGB7 Gene

mRNA/cDNA for CGB7 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB7

Alternative Splicing Database (ASD) splice patterns (SP) for CGB7 Gene

No ASD Table

Relevant External Links for CGB7 Gene

GeneLoc Exon Structure for
CGB7

Expression for CGB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CGB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CGB7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.9), Skin - Sun Exposed (Lower leg) (x6.5), Prostate (x4.5), and Esophagus - Mucosa (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CGB7

SOURCE GeneReport for Unigene cluster for CGB7 Gene:

Hs.681647

mRNA Expression by UniProt/SwissProt for CGB7 Gene:

P0DN87-CGB7_HUMAN
Tissue specificity: High expression in the placenta throughout pregnancy.

Evidence on tissue expression from TISSUES for CGB7 Gene

  • Eye(3.1)
  • Nervous system(2.6)
  • Adrenal gland(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with CGB7: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB7 Gene

Orthologs for CGB7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CGB7 30 31
  • 99.6 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LHB 31
  • 65 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LHB 31
  • 64 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Lhb 31
  • 62 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia LHB 31
  • 55 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 37 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii lhb 31
  • 39 (a)
OneToMany
Species where no ortholog for CGB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CGB7 Gene

ENSEMBL:
Gene Tree for CGB7 (if available)
TreeFam:
Gene Tree for CGB7 (if available)

Paralogs for CGB7 Gene

Paralogs for CGB7 Gene

(8) SIMAP similar genes for CGB7 Gene using alignment to 2 proteins:

  • CGHB_HUMAN
  • J3KP00_HUMAN
genes like me logo Genes that share paralogs with CGB7: view

Variants for CGB7 Gene

Additional dbSNP identifiers (rs#s) for CGB7 Gene

Structural Variations from Database of Genomic Variants (DGV) for CGB7 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
esv2675899 CNV deletion 23128226
esv3644611 CNV loss 21293372
esv3644612 CNV gain 21293372
nsv520785 CNV gain 19592680
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495
nsv978832 CNV duplication 23825009

Variation tolerance for CGB7 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGB7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CGB7 Gene

Disorders for CGB7 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CGB7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
trisomy 22
  • chromosome 22 trisomy
chromosomal triplication
  • trisomy
choriocarcinoma
  • chorioepithelioma
seminoma
  • seminoma, pure
- elite association - COSMIC cancer census association via MalaCards
Search CGB7 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CGB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB7 Gene

Publications for CGB7 Gene

  1. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PMID: 11861891) Maston GA … Ruvolo M (Molecular biology and evolution 2002) 3 4 23
  2. Expression of beta-subunit of HCG genes during normal and failed pregnancy. (PMID: 16123088) Rull K … Laan M (Human reproduction (Oxford, England) 2005) 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells. (PMID: 9012484) Bellet D … Vidaud M (Cancer research 1997) 3 23
  5. Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. (PMID: 1371113) Bo M … Boime I (The Journal of biological chemistry 1992) 3 23

Products for CGB7 Gene

Sources for CGB7 Gene