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This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
CGB3 (Chorionic Gonadotropin Subunit Beta 3) is a Protein Coding gene. Diseases associated with CGB3 include Ectopic Pregnancy and Placental Site Trophoblastic Tumor. Among its related pathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and Gene Expression. An important paralog of this gene is CGB5.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19J049024 | Promoter | 0.3 | EPDnew | 600.7 | +0.0 | 22 | 0.1 | CGB3 NTF6A KCNA7 ENSG00000268655 ENSG00000267335 | ||
GH19J049026 | Enhancer | 0.2 | Ensembl | 600.7 | -1.8 | -1826 | 0.4 | CGB3 NTF6A ENSG00000268655 KCNA7 NTF6G CGB2 ENSG00000267335 | ||
GH19J049018 | Promoter/Enhancer | 1.4 | FANTOM5 Ensembl ENCODE | 16.6 | +5.7 | 5674 | 3 | CTCF ZBTB33 IKZF1 LARP7 ZIC2 RBFOX2 PATZ1 REST TRIM22 EZH2 | ENSG00000268655 LOC101059948 LHB RUVBL2 CGB3 GYS1 CGB7 NTF4 | |
GH19J049012 | Enhancer | 0.9 | Ensembl ENCODE | 17.5 | +10.3 | 10313 | 2.2 | CREB1 ATF7 ZNF629 JUND PKNOX1 EGR1 ZBTB10 ATF2 FOSL1 ZFHX2 | ENSG00000268655 CGB3 CGB7 NTF4 KCNA7 LIN7B C19orf73 PPFIA3 RUVBL2 NUCB1 | |
GH19J049020 | Enhancer | 0.7 | FANTOM5 | 13.4 | +3.3 | 3306 | 0.3 | PRDM10 ZNF692 KLF9 ZBTB20 SP2 ZBTB17 MNT BHLHE40 ZNF2 KLF16 | ENSG00000268655 LOC101059948 CGB3 RUVBL2 GYS1 CGB7 NTF4 CGB5 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | contributes_to hormone activity | TAS,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide hormone metabolism | ||
2 | Gene Expression |
.48
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|
3 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors | ||
4 | Metabolism of proteins |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | -- |
GO:0006915 | apoptotic process | TAS | 7723844 |
GO:0007165 | signal transduction | TAS | 10468638 |
GO:0007186 | G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0007267 | cell-cell signaling | TAS | 6194155 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Luteinizing hormone releasing hormone human acetate salt (LHRH) | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Luteinizing hormone releasing hormone human acetate salt (LHRH) | 71447-49-9 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | LHB 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | LHB 31 |
|
OneToMany | |
Mouse (Mus musculus) |
Mammalia | Lhb 31 |
|
OneToMany | |
Oppossum (Monodelphis domestica) |
Mammalia | LHB 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | lhb 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1261895475 | - | p.Arg28Trp | |||
rs200199557 | - | p.Asp137Ala | |||
rs201240617 | - | p.Thr18Ala | |||
rs201373221 | - | p.Arg30His | |||
rs201575305 | - | p.Lys22Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
ectopic pregnancy |
|
|
placental site trophoblastic tumor |
|
|
seminoma |
|
|
germinoma |
|
|
teratoma |
|