CGB3 Gene (Protein Coding)

Chorionic Gonadotropin Subunit Beta 3

GC19M049024
GIFtS:
32
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the stero... See more...

Aliases for CGB3 Gene

Aliases for CGB3 Gene

  • Chorionic Gonadotropin Subunit Beta 3 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 2 3
  • Chorionic Gonadotropin Beta Subunit 3 2 3
  • Chorionic Gonadotropin Chain Beta 3 4
  • CG-Beta 3 4
  • CGB 3 4
  • Chorionic Gonadotropin Beta 3 Subunit 3
  • Chorionic Gonadotrophin Chain Beta 3
  • Choriogonadotropin Subunit Beta 3 3
  • Chorionic Gonadotropin Beta Chain 3
  • Choriogonadotropin Subunit Beta 4
  • CGB5 3
  • CGB7 3
  • CGB8 3
  • HCGB 3

External Ids for CGB3 Gene

Previous HGNC Symbols for CGB3 Gene

  • CGB

Summaries for CGB3 Gene

Entrez Gene Summary for CGB3 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB3 Gene

CGB3 (Chorionic Gonadotropin Subunit Beta 3) is a Protein Coding gene. Diseases associated with CGB3 include Ectopic Pregnancy and Placental Site Trophoblastic Tumor. Among its related pathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and Gene Expression. An important paralog of this gene is CGB5.

UniProtKB/Swiss-Prot Summary for CGB3 Gene

  • Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Gene Wiki entry for CGB3 Gene

Additional gene information for CGB3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CGB3 Gene

Genomics for CGB3 Gene

GeneHancer (GH) Regulatory Elements for CGB3 Gene

Promoters and enhancers for CGB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J049024 Promoter 0.3 EPDnew 750.6 +0.0 22 0.1 CGB3 NTF6A KCNA7 ENSG00000268655 ENSG00000267335
GH19J049026 Enhancer 0.2 Ensembl 750.6 -1.8 -1826 0.4 CGB3 NTF6A ENSG00000268655 KCNA7 NTF6G ENSG00000267335
GH19J049018 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 16.6 +5.7 5674 3 CTCF ZBTB6 L3MBTL2 SP7 CREM EGR1 GMEB1 IKZF1 GLIS2 ZIC2 ENSG00000268655 LOC101059948 LHB RUVBL2 CGB3 GYS1 CGB7 NTF4
GH19J049012 Enhancer 0.8 Ensembl ENCODE 17.5 +10.3 10313 2.2 SP7 EGR1 CREB1 ATF1 PKNOX1 ZNF629 ATF7 ZBTB10 FOSL1 ZFP69B ENSG00000268655 CGB3 PRR12 NUP62 ENSG00000268047 SNRNP70 PRMT1 ENSG00000268093 CGB7 NTF4
GH19J049020 Enhancer 0.6 FANTOM5 13.4 +3.3 3306 0.3 MNT PRDM10 ZNF692 SP2 ZBTB20 ZBTB17 BHLHE40 ZNF2 SP3 KLF16 ENSG00000268655 LOC101059948 CGB3 GYS1 RUVBL2 CGB7 NTF4 CGB5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGB3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CGB3 Gene

Genomic Locations for CGB3 Gene
chr19:49,022,869-49,024,375
(GRCh38/hg38)
Size:
1,507 bases
Orientation:
Minus strand
chr19:49,526,126-49,527,593
(GRCh37/hg19)
Size:
1,468 bases
Orientation:
Minus strand

Genomic View for CGB3 Gene

Genes around CGB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CGB3 Gene

Proteins for CGB3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CGB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN86-CGB3_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta 3
    Protein Accession:
    P0DN86
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • P01233
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB3 Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGB3 Gene

    Alternative splice isoforms for CGB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB3 Gene

Post-translational modifications for CGB3 Gene

  • Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CGB3_HUMAN (88, 91)

Other Protein References for CGB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for CGB3

No data available for DME Specific Peptides for CGB3 Gene

Domains & Families for CGB3 Gene

Gene Families for CGB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for CGB3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P0DN86

UniProtKB/Swiss-Prot:

CGB3_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB3: view

No data available for Suggested Antigen Peptide Sequences for CGB3 Gene

Function for CGB3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CGB3 Gene

UniProtKB/Swiss-Prot Function:
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Phenotypes From GWAS Catalog for CGB3 Gene

Gene Ontology (GO) - Molecular Function for CGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 contributes_to hormone activity IBA 21873635
genes like me logo Genes that share ontologies with CGB3: view
genes like me logo Genes that share phenotypes with CGB3: view

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for CGB3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB3 Gene

Localization for CGB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB3 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CGB3: view

Pathways & Interactions for CGB3 Gene

genes like me logo Genes that share pathways with CGB3: view

SIGNOR curated interactions for CGB3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II TAS --
GO:0006915 apoptotic process TAS 7723844
GO:0007165 signal transduction TAS 10468638
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007267 cell-cell signaling TAS 6194155
genes like me logo Genes that share ontologies with CGB3: view

Drugs & Compounds for CGB3 Gene

Products:

  1. Drug

(22) Drugs for CGB3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Luteinizing hormone releasing hormone human acetate salt (LHRH) Pharma 0

(7) Additional Compounds for CGB3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CGB3 Gene

Compound Action Cas Number
Luteinizing hormone releasing hormone human acetate salt (LHRH) 71447-49-9
genes like me logo Genes that share compounds with CGB3: view

Transcripts for CGB3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CGB3 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(409) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for CGB3

Alternative Splicing Database (ASD) splice patterns (SP) for CGB3 Gene

No ASD Table

Relevant External Links for CGB3 Gene

GeneLoc Exon Structure for
CGB3
ECgene alternative splicing isoforms for
CGB3

Expression for CGB3 Gene

Products:

  1. Primer
  2. Gene Expression Assay

NURSA nuclear receptor signaling pathways regulating expression of CGB3 Gene:

CGB3

mRNA Expression by UniProt/SwissProt for CGB3 Gene:

P0DN86-CGB3_HUMAN
Tissue specificity: High expression in the placenta throughout pregnancy.

Evidence on tissue expression from TISSUES for CGB3 Gene

  • Nervous system(2.6)
  • Adrenal gland(2)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB3 Gene

Orthologs for CGB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia -- 33
  • 97 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia LHB 33
  • 65 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia LHB 33
  • 64 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Lhb 33
  • 62 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia LHB 33
  • 55 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 36 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii lhb 33
  • 39 (a)
 OneToMany
Species where no ortholog for CGB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB3 Gene

ENSEMBL:
Gene Tree for CGB3 (if available)
TreeFam:
Gene Tree for CGB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CGB3: view image

Paralogs for CGB3 Gene

Paralogs for CGB3 Gene

genes like me logo Genes that share paralogs with CGB3: view

Variants for CGB3 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for CGB3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000188204 -- 49,024,229(-) A/G 5_prime_UTR_variant
rs1001094233 -- 49,022,790(-) C/G/T downstream_transcript_variant
rs1002922053 -- 49,025,469(-) C/T upstream_transcript_variant
rs1003371215 -- 49,024,504(-) C/G/T upstream_transcript_variant
rs1003446977 -- 49,025,577(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CGB3 Gene

Variant ID Type Subtype PubMed ID
esv22462 CNV gain 19812545
nsv579907 CNV loss 21841781
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for CGB3 Gene

Gene Damage Index Score: 0.32; 7.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGB3 Gene

Human Gene Mutation Database (HGMD)
CGB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB3 Gene

Disorders for CGB3 Gene

MalaCards: The human disease database

(29) MalaCards diseases for CGB3 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
placental site trophoblastic tumor
  • placental-site gestational trophoblastic neoplasm
tuberculous epididymitis
  • tuberculosis of epididymis
seminoma
  • seminoma, pure
germinoma
- elite association - COSMIC cancer census association via MalaCards
Search CGB3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CGB3

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CGB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB3 Gene

Publications for CGB3 Gene

  1. Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form. (PMID: 1688430) Beebe JS … Ruddon RW (The Journal of biological chemistry 1990) 3 4 23 56
  2. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The Journal of biological chemistry 1983) 2 3 4 56
  3. The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. (PMID: 6774259) Fiddes JC … Goodman HM (Nature 1980) 2 3 4 56
  4. Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells. (PMID: 18339208) Jankowska A … Warchol JB (Molecular cancer 2008) 3 23 56
  5. Coexpression of human chorionic gonadotropin beta subunit and its receptor in nontrophoblastic gynecological cancer. (PMID: 18217981) Jankowska A … Warchol JB (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2008) 3 23 56

ExternalLinks

View latest publications for CGB3 gene in Mastermind

Products for CGB3 Gene

  • Addgene plasmids for CGB3

Sources for CGB3 Gene