This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the stero... See more...

Aliases for CGB3 Gene

Aliases for CGB3 Gene

  • Chorionic Gonadotropin Subunit Beta 3 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 2 3
  • Chorionic Gonadotropin Beta Subunit 3 2 3
  • Choriogonadotropin Subunit Beta 3 3 4
  • Chorionic Gonadotropin Chain Beta 3 4
  • CG-Beta 3 4
  • CGB 3 4
  • Chorionic Gonadotropin Beta 3 Subunit 3
  • Chorionic Gonadotrophin Chain Beta 3
  • Chorionic Gonadotropin Beta Chain 3
  • Luteinizing Hormone Beta Subunit 3
  • Choriogonadotropin Subunit Beta 4
  • CGB5 3
  • CGB7 3
  • CGB8 3
  • HCGB 3
  • CGB3 5
  • LHB 3

External Ids for CGB3 Gene

Previous HGNC Symbols for CGB3 Gene

  • CGB

Summaries for CGB3 Gene

Entrez Gene Summary for CGB3 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB3 Gene

CGB3 (Chorionic Gonadotropin Subunit Beta 3) is a Protein Coding gene. Diseases associated with CGB3 include Ectopic Pregnancy and Endodermal Sinus Tumor. Among its related pathways are Peptide hormone metabolism and Gene Expression. An important paralog of this gene is CGB5.

UniProtKB/Swiss-Prot Summary for CGB3 Gene

  • Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Gene Wiki entry for CGB3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CGB3 Gene

Genomics for CGB3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CGB3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049024 Promoter 0.3 EPDnew 250.7 0.0 -20 0.1 CGB3 HSALNG0126944 NTF6A KCNA7 CGB2 ENSG00000267335
GH19J049018 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE 16.6 +5.6 5632 3 IKZF1 ZNF600 ZNF592 NFIC ZIC2 MXD4 NONO REST TARDBP CHD2 LOC101059948 LHB RUVBL2 CGB3 GYS1 CGB7 NTF4
GH19J049012 Enhancer 0.7 ENCODE 17.5 +10.3 10271 2.2 ATF2 ZBTB10 JUND ATF1 NCOA1 ZBTB33 EGR1 ATF4 ZBTB21 ZNF398 LOC101059948 CGB3 CGB7 NTF4 KCNA7 LIN7B C19orf73 PPFIA3 RUVBL2 NUCB1
GH19J049020 Enhancer 0.7 FANTOM5 13.4 +3.3 3264 0.3 BHLHE40 MNT KLF9 SP2 KLF16 ZNF2 KLF1 GABPB1 SP3 ZNF169 LOC101059948 CGB3 GYS1 RUVBL2 CGB7 NTF4 CGB5 HSALNG0126944 LHB
GH19J049032 Promoter 1 EPDnew 0.4 -7.5 -7538 0.1 MYC ZNF580 ATF2 NFIC REST TARDBP TRIM22 BHLHE40 TBP ARNT CGB2 SNAR-G2 KCNA7 ENSG00000267335 CGB3 HSALNG0126944
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGB3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CGB3

Genomic Locations for CGB3 Gene

Latest Assembly
chr19:49,022,869-49,024,333
(GRCh38/hg38)
Size:
1,465 bases
Orientation:
Minus strand

Previous Assembly
chr19:49,526,126-49,527,632
(GRCh37/hg19 by Entrez Gene)
Size:
1,507 bases
Orientation:
Minus strand

chr19:49,526,126-49,527,590
(GRCh37/hg19 by Ensembl)
Size:
1,465 bases
Orientation:
Minus strand

Genomic View for CGB3 Gene

Genes around CGB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB3 Gene

Proteins for CGB3 Gene

  • Protein details for CGB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN86-CGB3_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta 3
    Protein Accession:
    P0DN86
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • P01233
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB3 Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.

    Three dimensional structures from OCA and Proteopedia for CGB3 Gene

    Alternative splice isoforms for CGB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB3 Gene

Post-translational modifications for CGB3 Gene

  • Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CGB3_HUMAN (88, 91)

Other Protein References for CGB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for CGB3 Gene

Domains & Families for CGB3 Gene

Gene Families for CGB3 Gene

Graphical View of Domain Structure for InterPro Entry

P0DN86

UniProtKB/Swiss-Prot:

CGB3_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB3: view

No data available for Suggested Antigen Peptide Sequences for CGB3 Gene

Function for CGB3 Gene

Molecular function for CGB3 Gene

UniProtKB/Swiss-Prot Function:
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Phenotypes From GWAS Catalog for CGB3 Gene

Gene Ontology (GO) - Molecular Function for CGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 contributes_to hormone activity TAS,IBA 21873635
GO:0005515 protein binding IPI 7922031
genes like me logo Genes that share ontologies with CGB3: view
genes like me logo Genes that share phenotypes with CGB3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB3 Gene

Localization for CGB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB3 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CGB3: view

Pathways & Interactions for CGB3 Gene

genes like me logo Genes that share pathways with CGB3: view

SIGNOR curated interactions for CGB3 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CGB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II TAS --
GO:0006915 apoptotic process TAS 7723844
GO:0007165 signal transduction TAS 10468638
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007267 cell-cell signaling TAS 6194155
genes like me logo Genes that share ontologies with CGB3: view

Drugs & Compounds for CGB3 Gene

(22) Drugs for CGB3 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Luteinizing hormone releasing hormone human acetate salt (LHRH) Pharma 0

(7) Additional Compounds for CGB3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CGB3 Gene

genes like me logo Genes that share compounds with CGB3: view

Transcripts for CGB3 Gene

mRNA/cDNA for CGB3 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB3

Alternative Splicing Database (ASD) splice patterns (SP) for CGB3 Gene

No ASD Table

Relevant External Links for CGB3 Gene

GeneLoc Exon Structure for
CGB3

Expression for CGB3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CGB3

mRNA Expression by UniProt/SwissProt for CGB3 Gene:

P0DN86-CGB3_HUMAN
Tissue specificity: High expression in the placenta throughout pregnancy.

Evidence on tissue expression from TISSUES for CGB3 Gene

  • Nervous system(2.8)

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB3 Gene

Orthologs for CGB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 97 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia LHB 30
  • 65 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LHB 30
  • 64 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Lhb 30
  • 62 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia LHB 30
  • 55 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 36 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii lhb 30
  • 39 (a)
OneToMany
Species where no ortholog for CGB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CGB3 Gene

ENSEMBL:
Gene Tree for CGB3 (if available)
TreeFam:
Gene Tree for CGB3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CGB3: view image
Alliance of Genome Resources:
Additional Orthologs for CGB3

Paralogs for CGB3 Gene

Paralogs for CGB3 Gene

genes like me logo Genes that share paralogs with CGB3: view

Variants for CGB3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CGB3 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs126189547 -- p.Arg28Trp
rs200199557 -- p.Asp137Ala
rs201240617 -- p.Thr18Ala
rs201373221 -- p.Arg30His
rs201575305 -- p.Lys22Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CGB3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CGB3 Gene

Variant ID Type Subtype PubMed ID
esv22462 CNV gain 19812545
nsv579907 CNV loss 21841781
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495

Variation tolerance for CGB3 Gene

Gene Damage Index Score: 0.32; 7.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGB3 Gene

Human Gene Mutation Database (HGMD)
CGB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB3
Leiden Open Variation Database (LOVD)
CGB3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB3 Gene

Disorders for CGB3 Gene

MalaCards: The human disease database

(28) MalaCards diseases for CGB3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
endodermal sinus tumor
  • endodermal sinus tumour
placental site trophoblastic tumor
  • placental site trophoblastic tumour
seminoma
  • seminoma, pure
germinoma
- elite association - COSMIC cancer census association via MalaCards
Search CGB3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CGB3

genes like me logo Genes that share disorders with CGB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB3 Gene

Publications for CGB3 Gene

  1. Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form. (PMID: 1688430) Beebe JS … Ruddon RW (The Journal of biological chemistry 1990) 3 4 22
  2. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The Journal of biological chemistry 1983) 2 3 4
  3. The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. (PMID: 6774259) Fiddes JC … Goodman HM (Nature 1980) 2 3 4
  4. The prognostic value of tumor markers in newly diagnosed patients with primary central nervous system germ cell tumors. (PMID: 18802946) Kim A … Finlay JL (Pediatric blood & cancer 2008) 3 22
  5. Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells. (PMID: 18339208) Jankowska A … Warchol JB (Molecular cancer 2008) 3 22

Products for CGB3 Gene

Sources for CGB3 Gene