The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to ... See more...

Aliases for CGB2 Gene

Aliases for CGB2 Gene

  • Chorionic Gonadotropin Subunit Beta 2 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 2 2 3
  • Choriogonadotropin Subunit Beta Variant 2 3 4
  • Chorionic Gonadotropin Beta Subunit 2 2 3
  • Product Of CGB2 3
  • CGB2 5

External Ids for CGB2 Gene

Previous GeneCards Identifiers for CGB2 Gene

  • GC19P050193
  • GC19P049866
  • GC19P054211
  • GC19P054226
  • GC19P049535
  • GC19P045911

Summaries for CGB2 Gene

Entrez Gene Summary for CGB2 Gene

  • The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB2 Gene

CGB2 (Chorionic Gonadotropin Subunit Beta 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CGB3.

Gene Wiki entry for CGB2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CGB2 Gene

Genomics for CGB2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CGB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049032 Promoter 1 EPDnew 600.7 0.0 -19 0.1 CREB1 CTCF ZBTB33 ATF7 LEF1 JUND ZNF143 ZNF24 REST NR2C1 CGB2 SNAR-G2 PRR12 KCNA7 SCAF1 PTOV1 CGB3 ENSG00000267335
GH19J049031 Promoter 1 EPDnew 600.7 +0.1 96 0.1 CTCF ZBTB33 ATF7 LEF1 ZNF143 ZNF24 NR2C1 TRIM22 HDAC1 SOX6 CGB2 SNAR-G2 KCNA7 SCAF1 PRR12 PTOV1 CGB1 ENSG00000267335
GH19J049029 Promoter/Enhancer 0.6 EPDnew Ensembl 608.3 -1.9 -1889 0.8 PRDM10 CGB2 NTF6G SNAR-G2 CGB5 KCNA7 CGB8 ENSG00000269534 CGB3 ENSG00000267335
GH19J049050 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 9.7 +18.6 18622 1 ZBTB33 PRDM10 ZNF629 ZIC2 PATZ1 FOS SIN3A ZNF335 BHLHE40 KLF17 CGB8 ENSG00000269706 LOC100287489 lnc-CGB8-1 KCNA7 CGB2 CGB7
GH19J049038 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 8.4 +6.9 6911 1.6 PRDM10 ZNF629 IKZF1 ZIC2 CREB1 FOSL1 FOSL2 SIN3A DPF2 ZFP3 CGB1 ENSG00000267335 NTF6B SNAR-G1 CGB7 NTF4 CGB2 RUVBL2 CGB5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGB2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CGB2

Top Transcription factor binding sites by QIAGEN in the CGB2 gene promoter:
  • AhR
  • Egr-3
  • GATA-1
  • NF-1
  • NF-1/L
  • Pax-5

Genomic Locations for CGB2 Gene

Genomic Locations for CGB2 Gene
chr19:49,031,890-49,033,238
(GRCh38/hg38)
Size:
1,349 bases
Orientation:
Plus strand
chr19:49,535,130-49,536,495
(GRCh37/hg19)
Size:
1,366 bases
Orientation:
Plus strand

Genomic View for CGB2 Gene

Genes around CGB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB2 Gene

Proteins for CGB2 Gene

  • Protein details for CGB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT52-CGB2_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta variant 2
    Protein Accession:
    Q6NT52
    Secondary Accessions:
    • B9ZVM5
    • H9KV56

    Protein attributes for CGB2 Gene

    Size:
    163 amino acids
    Molecular mass:
    17374 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH69367.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.

neXtProt entry for CGB2 Gene

Post-translational modifications for CGB2 Gene

  • Glycosylation at Asn31 and Asn48
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB2 Gene

No data available for DME Specific Peptides for CGB2 Gene

Domains & Families for CGB2 Gene

Gene Families for CGB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CGB2 Gene

InterPro:
Blocks:
  • Growth factor cystine knot superfamily signature
ProtoNet:

Suggested Antigen Peptide Sequences for CGB2 Gene

GenScript: Design optimal peptide antigens:
  • Chorionic gonadotropin beta subunit 2 (C7EA52_HUMAN)
  • Choriogonadotropin subunit beta variant 2 (CGB2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6NT52

UniProtKB/Swiss-Prot:

CGB2_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB2: view

Function for CGB2 Gene

Gene Ontology (GO) - Molecular Function for CGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 19523396
genes like me logo Genes that share ontologies with CGB2: view
genes like me logo Genes that share phenotypes with CGB2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB2 Gene

Localization for CGB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB2 gene
Compartment Confidence
extracellular 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CGB2: view

Pathways & Interactions for CGB2 Gene

PathCards logo

SuperPathways for CGB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0009755 hormone-mediated signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CGB2: view

No data available for Pathways by source and SIGNOR curated interactions for CGB2 Gene

Drugs & Compounds for CGB2 Gene

No Compound Related Data Available

Transcripts for CGB2 Gene

mRNA/cDNA for CGB2 Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB2

Alternative Splicing Database (ASD) splice patterns (SP) for CGB2 Gene

No ASD Table

Relevant External Links for CGB2 Gene

GeneLoc Exon Structure for
CGB2

Expression for CGB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CGB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CGB2 Gene

This gene is overexpressed in Testis (x15.7), Brain - Putamen (basal ganglia) (x10.4), Brain - Caudate (basal ganglia) (x5.2), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Hippocampus (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CGB2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CGB2

SOURCE GeneReport for Unigene cluster for CGB2 Gene:

Hs.567650

mRNA Expression by UniProt/SwissProt for CGB2 Gene:

Q6NT52-CGB2_HUMAN
Tissue specificity: Expressed in placenta, testis and pituitary.
genes like me logo Genes that share expression patterns with CGB2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB2 Gene

Orthologs for CGB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia LHB 31
  • 62 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia LHB 31
  • 62 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Lhb 31
  • 60 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia LHB 31
  • 54 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 37 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii lhb 31
  • 39 (a)
OneToMany
Species where no ortholog for CGB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CGB2 Gene

ENSEMBL:
Gene Tree for CGB2 (if available)
TreeFam:
Gene Tree for CGB2 (if available)

Paralogs for CGB2 Gene

Paralogs for CGB2 Gene

(8) SIMAP similar genes for CGB2 Gene using alignment to 3 proteins:

  • CGB2_HUMAN
  • H9KV56_HUMAN
  • M0R0E6_HUMAN
genes like me logo Genes that share paralogs with CGB2: view

Variants for CGB2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CGB2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769979 Benign: not provided 49,033,133(+) C/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for CGB2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CGB2 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
esv2718698 CNV deletion 23290073
nsv579907 CNV loss 21841781
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv960856 CNV duplication 23825009
nsv9739 CNV gain+loss 18304495

Variation tolerance for CGB2 Gene

Gene Damage Index Score: 7.62; 82.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB2 Gene

Disorders for CGB2 Gene

No disorders were found for CGB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CGB2 Gene

Publications for CGB2 Gene

  1. Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. (PMID: 18048458) Rull K … Laan M (Molecular human reproduction 2008) 3 4
  2. The evolution and genomic landscape of CGB1 and CGB2 genes. (PMID: 17055150) Hallast P … Laan M (Molecular and cellular endocrinology 2007) 3 23
  3. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The Journal of biological chemistry 1983) 2 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ. (PMID: 24778026) Burczynska BB … Iles RK (Anticancer research 2014) 3

Products for CGB2 Gene

Sources for CGB2 Gene