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Aliases for CGB2 Gene

Aliases for CGB2 Gene

  • Chorionic Gonadotropin Subunit Beta 2 2 3
  • Chorionic Gonadotropin Beta Subunit 2 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 2 2 3
  • Choriogonadotropin Subunit Beta Variant 2 3
  • Product Of CGB2 3

External Ids for CGB2 Gene

Previous GeneCards Identifiers for CGB2 Gene

  • GC19P050193
  • GC19P049866
  • GC19P054211
  • GC19P054226
  • GC19P049535
  • GC19P045911

Summaries for CGB2 Gene

Entrez Gene Summary for CGB2 Gene

  • The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB2 Gene

CGB2 (Chorionic Gonadotropin Subunit Beta 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CGB8.

Gene Wiki entry for CGB2 Gene

Additional gene information for CGB2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB2 Gene

Genomics for CGB2 Gene

GeneHancer (GH) Regulatory Elements for CGB2 Gene

Promoters and enhancers for CGB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049031 Promoter 1.1 EPDnew 650.7 +0.1 113 0.1 HDAC1 ATF1 RB1 ARNT ZBTB40 E2F8 POLR3A ZNF143 ATF7 NFYC CGB2 SNAR-G2 KCNA7 SCAF1 PRR12 PTOV1 ENSG00000267335
GH19J049032 Promoter 1.1 EPDnew 650.7 0.0 -2 0.1 HDAC1 ATF1 RB1 ARNT ZBTB40 E2F8 POLR3A ZNF143 ATF7 CREM SNAR-G2 CGB2 PRR12 KCNA7 SCAF1 PTOV1 ENSG00000267335
GH19J049029 Promoter 0.6 EPDnew 650.7 -1.9 -1876 0.1 PRDM10 SNAR-G2 NTF6G CGB2 CGB5 KCNA7 ENSG00000269534 ENSG00000267335
GH19J049050 Promoter/Enhancer 1.1 EPDnew ENCODE 9.6 +18.6 18617 0.9 KLF1 ZBTB21 KLF17 SIN3A ZIC2 ZNF335 GLIS2 JUND ZFP3 PATZ1 CGB8 LOC100287489 GC19M049052 KCNA7 CGB2
GH19J049036 Promoter 1.1 EPDnew 0.7 +4.9 4949 0.1 HDAC1 PKNOX1 ATF1 RB1 ARNT ZBTB40 E2F8 FOS ATF7 CREM CGB1 SNAR-G1 ENSG00000267335 CGB7 NTF4 LOC101059948 CGB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CGB2 gene promoter:
  • Pax-5
  • NF-1
  • NF-1/L
  • GATA-1
  • AhR
  • Egr-3

Genomic Locations for CGB2 Gene

Genomic Locations for CGB2 Gene
1,366 bases
Plus strand
1,366 bases
Plus strand

Genomic View for CGB2 Gene

Genes around CGB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB2 Gene

Proteins for CGB2 Gene

  • Protein details for CGB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choriogonadotropin subunit beta variant 2
    Protein Accession:
    Secondary Accessions:
    • B9ZVM5
    • H9KV56

    Protein attributes for CGB2 Gene

    163 amino acids
    Molecular mass:
    17374 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH69367.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for CGB2 Gene

Post-translational modifications for CGB2 Gene

  • Glycosylation at posLast=8080 and Asn63
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB2 Gene

No data available for DME Specific Peptides for CGB2 Gene

Domains & Families for CGB2 Gene

Gene Families for CGB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CGB2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycoprotein hormones subunit beta family.
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB2: view

Function for CGB2 Gene

Gene Ontology (GO) - Molecular Function for CGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 19523396
genes like me logo Genes that share ontologies with CGB2: view
genes like me logo Genes that share phenotypes with CGB2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB2 Gene

Localization for CGB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB2 gene
Compartment Confidence
extracellular 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CGB2: view

Pathways & Interactions for CGB2 Gene

No Data Available

Interacting Proteins for CGB2 Gene

Gene Ontology (GO) - Biological Process for CGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
GO:0009755 hormone-mediated signaling pathway IBA --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0030728 ovulation IBA --
genes like me logo Genes that share ontologies with CGB2: view

No data available for Pathways by source and SIGNOR curated interactions for CGB2 Gene

Drugs & Compounds for CGB2 Gene

No Compound Related Data Available

Transcripts for CGB2 Gene

mRNA/cDNA for CGB2 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(247) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CGB2 Gene

Chorionic gonadotropin, beta polypeptide 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGB2 Gene

No ASD Table

Relevant External Links for CGB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CGB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CGB2 Gene

mRNA differential expression in normal tissues according to GTEx for CGB2 Gene

This gene is overexpressed in Testis (x15.7), Brain - Putamen (basal ganglia) (x10.4), Brain - Caudate (basal ganglia) (x5.2), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Hippocampus (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CGB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CGB2 Gene:


SOURCE GeneReport for Unigene cluster for CGB2 Gene:


mRNA Expression by UniProt/SwissProt for CGB2 Gene:

Tissue specificity: Expressed in placenta, testis and pituitary.
genes like me logo Genes that share expression patterns with CGB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB2 Gene

Orthologs for CGB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LHB 34
  • 62 (a)
(Canis familiaris)
Mammalia LHB 34
  • 62 (a)
(Mus musculus)
Mammalia Lhb 34
  • 60 (a)
(Monodelphis domestica)
Mammalia LHB 34
  • 54 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
(Danio rerio)
Actinopterygii lhb 34
  • 39 (a)
Species where no ortholog for CGB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB2 Gene

Gene Tree for CGB2 (if available)
Gene Tree for CGB2 (if available)

Paralogs for CGB2 Gene

Paralogs for CGB2 Gene

(8) SIMAP similar genes for CGB2 Gene using alignment to 3 proteins:

  • H9KV56_HUMAN
  • M0R0E6_HUMAN
genes like me logo Genes that share paralogs with CGB2: view

Variants for CGB2 Gene

Sequence variations from dbSNP and Humsavar for CGB2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000447906 -- 49,031,911(+) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001724214 -- 49,031,721(+) C/G/T upstream_transcript_variant
rs1002007268 -- 49,030,785(+) A/G upstream_transcript_variant
rs1003520882 -- 49,032,911(+) G/A/C coding_sequence_variant, missense_variant
rs1003734032 -- 49,030,256(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for CGB2 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
esv2718698 CNV deletion 23290073
nsv579907 CNV loss 21841781
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv960856 CNV duplication 23825009
nsv9739 CNV gain+loss 18304495

Variation tolerance for CGB2 Gene

Gene Damage Index Score: 7.62; 82.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB2 Gene

Disorders for CGB2 Gene

Additional Disease Information for CGB2

No disorders were found for CGB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CGB2 Gene

Publications for CGB2 Gene

  1. Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. (PMID: 18048458) Rull K … Laan M (Molecular human reproduction 2008) 3 4 58
  2. The evolution and genomic landscape of CGB1 and CGB2 genes. (PMID: 17055150) Hallast P … Laan M (Molecular and cellular endocrinology 2007) 3 22 58
  3. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The Journal of biological chemistry 1983) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ. (PMID: 24778026) Burczynska BB … Iles RK (Anticancer research 2014) 3 58

Products for CGB2 Gene

Sources for CGB2 Gene

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