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Aliases for CGB1 Gene

Aliases for CGB1 Gene

  • Chorionic Gonadotropin Subunit Beta 1 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 1 2 3
  • Choriogonadotropin Subunit Beta Variant 1 3 4
  • Chorionic Gonadotropin Beta Subunit 1 2 3

External Ids for CGB1 Gene

Previous GeneCards Identifiers for CGB1 Gene

  • GC19M050185
  • GC19M049895
  • GC19M054203
  • GC19M054219
  • GC19M054230
  • GC19M054224
  • GC19M049538
  • GC19M045915

Summaries for CGB1 Gene

Entrez Gene Summary for CGB1 Gene

  • The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB1 Gene

CGB1 (Chorionic Gonadotropin Subunit Beta 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CGB2.

Gene Wiki entry for CGB1 Gene

Additional gene information for CGB1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB1 Gene

Genomics for CGB1 Gene

GeneHancer (GH) Regulatory Elements for CGB1 Gene

Promoters and enhancers for CGB1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049038 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.7 -2.0 -1967 1 SMARCA4 CREB1 IKZF1 PRDM10 ZIC2 ZNF629 FOSL1 FOSL2 SIN3A DPF2 CGB1 NTF6B SNAR-G1 NTF4 CGB7 RUVBL2
GH19J049036 Promoter 1.1 EPDnew 600.7 +0.1 112 0.1 CC2D1A CSDE1 CREB1 ZBTB33 LEF1 ATF1 REST CTCF PKNOX1 ATF7 CGB1 ENSG00000267335 SNAR-G1 CGB7 NTF4 ENSG00000268655 CGB2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CGB1 gene promoter:
  • AhR
  • Egr-4
  • NF-1
  • NF-1/L
  • Pax-5

Genomic Locations for CGB1 Gene

Genomic Locations for CGB1 Gene
1,366 bases
Minus strand
13,181 bases
Minus strand

Genomic View for CGB1 Gene

Genes around CGB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB1 Gene

Proteins for CGB1 Gene

  • Protein details for CGB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Choriogonadotropin subunit beta variant 1
    Protein Accession:
    Secondary Accessions:
    • A4FVC8
    • A8MUK6

    Protein attributes for CGB1 Gene

    187 amino acids
    Molecular mass:
    20468 Da
    Quaternary structure:
    No Data Available
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.

    Alternative splice isoforms for CGB1 Gene


neXtProt entry for CGB1 Gene

Post-translational modifications for CGB1 Gene

  • Glycosylation at posLast=8080 and isoforms=263
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB1 Gene

Domains & Families for CGB1 Gene

Gene Families for CGB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CGB1 Gene

Suggested Antigen Peptide Sequences for CGB1 Gene

GenScript: Design optimal peptide antigens:
  • Chorionic gonadotropin beta subunit 1 (C7EA76_HUMAN)
  • Choriogonadotropin subunit beta variant 1 (CGB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycoprotein hormones subunit beta family.
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB1: view

Function for CGB1 Gene

Gene Ontology (GO) - Molecular Function for CGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 19523396
genes like me logo Genes that share ontologies with CGB1: view
genes like me logo Genes that share phenotypes with CGB1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB1 Gene

Localization for CGB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB1 gene
Compartment Confidence
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CGB1: view

Pathways & Interactions for CGB1 Gene

PathCards logo

SuperPathways for CGB1 Gene

No Data Available

Interacting Proteins for CGB1 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
Selected Interacting proteins: A6NKQ9-CGB1_HUMAN ENSP00000301407 for CGB1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for CGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0009755 hormone-mediated signaling pathway IBA 21873635
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with CGB1: view

No data available for Pathways by source and SIGNOR curated interactions for CGB1 Gene

Drugs & Compounds for CGB1 Gene

No Compound Related Data Available

Transcripts for CGB1 Gene

mRNA/cDNA for CGB1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(409) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for CGB1 Gene

Chorionic gonadotropin, beta polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB1

Alternative Splicing Database (ASD) splice patterns (SP) for CGB1 Gene

No ASD Table

Relevant External Links for CGB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CGB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CGB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CGB1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CGB1 Gene:


SOURCE GeneReport for Unigene cluster for CGB1 Gene:


mRNA Expression by UniProt/SwissProt for CGB1 Gene:

Tissue specificity: Expressed in placenta, testis and pituitary.
genes like me logo Genes that share expression patterns with CGB1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB1 Gene

Orthologs for CGB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LHB 35
  • 60 (a)
(Canis familiaris)
Mammalia LHB 35
  • 60 (a)
(Mus musculus)
Mammalia Lhb 35
  • 58 (a)
(Monodelphis domestica)
Mammalia LHB 35
  • 52 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
(Danio rerio)
Actinopterygii lhb 35
  • 39 (a)
Species where no ortholog for CGB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB1 Gene

Gene Tree for CGB1 (if available)
Gene Tree for CGB1 (if available)

Paralogs for CGB1 Gene

Paralogs for CGB1 Gene

(8) SIMAP similar genes for CGB1 Gene using alignment to 3 proteins:

  • J3QT02_HUMAN
genes like me logo Genes that share paralogs with CGB1: view

Variants for CGB1 Gene

Sequence variations from dbSNP and Humsavar for CGB1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000388115 -- 49,038,170(-) T/C upstream_transcript_variant
rs1000442863 -- 49,038,348(-) A/C upstream_transcript_variant
rs1002542292 -- 49,038,918(-) G/A/T upstream_transcript_variant
rs1002736778 -- 49,036,378(-) C/T intron_variant
rs1002813143 -- 49,036,922(-) A/C 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CGB1 Gene

Variant ID Type Subtype PubMed ID
nsv978832 CNV duplication 23825009
nsv9739 CNV gain+loss 18304495
nsv953598 CNV deletion 24416366
nsv833859 CNV loss 17160897
nsv833857 CNV loss 17160897
nsv579907 CNV loss 21841781
esv2718698 CNV deletion 23290073
esv22462 CNV gain 19812545
dgv592n67 CNV loss 20364138

Variation tolerance for CGB1 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.08; 80.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB1 Gene

Disorders for CGB1 Gene

Additional Disease Information for CGB1

No disorders were found for CGB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CGB1 Gene

Publications for CGB1 Gene

  1. Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. (PMID: 18048458) Rull K … Laan M (Molecular human reproduction 2008) 3 4 58
  2. The evolution and genomic landscape of CGB1 and CGB2 genes. (PMID: 17055150) Hallast P … Laan M (Molecular and cellular endocrinology 2007) 3 23 58
  3. Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays. (PMID: 11368883) Giovangrandi Y … Bièche I (Cancer letters 2001) 3 23 58
  4. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The Journal of biological chemistry 1983) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for CGB1 Gene

Sources for CGB1 Gene

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