CGB1 Gene (Protein Coding)

Chorionic Gonadotropin Subunit Beta 1

GC19M049035
GIFtS:
27
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to ... See more...

Aliases for CGB1 Gene

Aliases for CGB1 Gene

  • Chorionic Gonadotropin Subunit Beta 1 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 1 2 3
  • Choriogonadotropin Subunit Beta Variant 1 3 4
  • Chorionic Gonadotropin Beta Subunit 1 2 3
  • CGB1 5

External Ids for CGB1 Gene

Previous GeneCards Identifiers for CGB1 Gene

  • GC19M050185
  • GC19M049895
  • GC19M054203
  • GC19M054219
  • GC19M054230
  • GC19M054224
  • GC19M049538
  • GC19M045915

Summaries for CGB1 Gene

Entrez Gene Summary for CGB1 Gene

  • The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB1 Gene

CGB1 (Chorionic Gonadotropin Subunit Beta 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is CGB3.

Gene Wiki entry for CGB1 Gene

Additional gene information for CGB1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CGB1 Gene

Genomics for CGB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for CGB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J049038 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 600.7 -1.9 -1906 1.6 PRDM10 ZNF629 IKZF1 ZIC2 CREB1 FOSL1 FOSL2 SIN3A DPF2 ZFP3 CGB1 ENSG00000267335 NTF6B SNAR-G1 CGB7 NTF4 CGB2 RUVBL2 CGB5
GH19J049036 Promoter 0.9 EPDnew 600.7 +0.1 73 0.1 CREB1 CTCF ZBTB33 ATF7 ZNF629 LEF1 JUND PKNOX1 REST HDAC1 CGB1 ENSG00000267335 SNAR-G1 CGB7 NTF4 ENSG00000268655 CGB2
GH19J049031 Promoter 1 EPDnew 0.7 +4.9 4909 0.1 CTCF ZBTB33 ATF7 LEF1 ZNF143 ZNF24 NR2C1 TRIM22 HDAC1 SOX6 CGB2 SNAR-G2 KCNA7 SCAF1 PRR12 PTOV1 CGB1 ENSG00000267335
GH19J049042 Promoter/Enhancer 0.8 EPDnew Ensembl 0.4 -5.4 -5406 1 ZIC2 ZNF335 ZFP3 GLIS1 JUND CGB5 ENSG00000268669 LOC100287453 lnc-CGB5-1 NTF4 CGB2 CGB1 ENSG00000267335
GH19J049039 Enhancer 0.3 Ensembl 0.7 -3.0 -3006 0.2 PRDM10 NTF6B NTF4 RUVBL2 CGB7 CGB1 CGB5 ENSG00000267335 LOC100287453
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CGB1

Top Transcription factor binding sites by QIAGEN in the CGB1 gene promoter:
  • AhR
  • Egr-4
  • NF-1
  • NF-1/L
  • Pax-5

Genomic Locations for CGB1 Gene

Genomic Locations for CGB1 Gene
chr19:49,035,569-49,036,895
(GRCh38/hg38)
Size:
1,327 bases
Orientation:
Minus strand
chr19:49,538,826-49,552,006
(GRCh37/hg19)
Size:
13,181 bases
Orientation:
Minus strand

Genomic View for CGB1 Gene

Genes around CGB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CGB1 Gene

Proteins for CGB1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CGB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKQ9-CGB1_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta variant 1
    Protein Accession:
    A6NKQ9
    Secondary Accessions:
    • A4FVC8
    • A8MUK6

    Protein attributes for CGB1 Gene

    Size:
    187 amino acids
    Molecular mass:
    20468 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common ancestor of the anthropoid primates.

    Alternative splice isoforms for CGB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB1 Gene

Protein Expression for CGB1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CGB1 Gene

  • Glycosylation at Asn63 and Asn80
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB1 Gene

Domains & Families for CGB1 Gene

Gene Families for CGB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CGB1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CGB1 Gene

GenScript: Design optimal peptide antigens:
  • Chorionic gonadotropin beta subunit 1 (C7EA76_HUMAN)
  • Choriogonadotropin subunit beta variant 1 (CGB1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NKQ9

UniProtKB/Swiss-Prot:

CGB1_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB1: view

Function for CGB1 Gene

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  6. Cell Line

Gene Ontology (GO) - Molecular Function for CGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA,IMP 19523396
genes like me logo Genes that share ontologies with CGB1: view
genes like me logo Genes that share phenotypes with CGB1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB1 Gene

Localization for CGB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB1 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with CGB1: view

Pathways & Interactions for CGB1 Gene

PathCards logo

SuperPathways for CGB1 Gene

No Data Available

Interacting Proteins for CGB1 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000301407 A6NKQ9-CGB1_HUMAN for CGB1 Gene via STRING IID

GPS-Prot Interaction Network for CGB1

Gene Ontology (GO) - Biological Process for CGB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0009755 hormone-mediated signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with CGB1: view

No data available for Pathways by source and SIGNOR curated interactions for CGB1 Gene

Drugs & Compounds for CGB1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for CGB1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CGB1 Gene

2 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGB1

Alternative Splicing Database (ASD) splice patterns (SP) for CGB1 Gene

No ASD Table

Relevant External Links for CGB1 Gene

GeneLoc Exon Structure for
CGB1

Expression for CGB1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CGB1 Gene

mRNA expression in normal human tissues for CGB1 Gene
mRNA expression by GTEx for CGB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CGB1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CGB1

SOURCE GeneReport for Unigene cluster for CGB1 Gene:

Hs.659014

mRNA Expression by UniProt/SwissProt for CGB1 Gene:

A6NKQ9-CGB1_HUMAN
Tissue specificity: Expressed in placenta, testis and pituitary.
genes like me logo Genes that share expression patterns with CGB1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB1 Gene

Orthologs for CGB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
 Mammalia LHB 31
  • 60 (a)
 OneToMany
Cow
(Bos Taurus)
 Mammalia LHB 31
  • 60 (a)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Lhb 31
  • 58 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia LHB 31
  • 52 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 36 (a)
 OneToMany
Zebrafish
(Danio rerio)
 Actinopterygii lhb 31
  • 39 (a)
 OneToMany
Species where no ortholog for CGB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CGB1 Gene

ENSEMBL:
Gene Tree for CGB1 (if available)
TreeFam:
Gene Tree for CGB1 (if available)

Paralogs for CGB1 Gene

Paralogs for CGB1 Gene

(8) SIMAP similar genes for CGB1 Gene using alignment to 3 proteins:

  • CGB1_HUMAN
  • J3QT02_HUMAN
  • K7ELM3_HUMAN
genes like me logo Genes that share paralogs with CGB1: view

Variants for CGB1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CGB1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs35371968 - p.Pro185Ser

Additional dbSNP identifiers (rs#s) for CGB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CGB1 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
esv2718698 CNV deletion 23290073
nsv579907 CNV loss 21841781
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495
nsv978832 CNV duplication 23825009

Variation tolerance for CGB1 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.08; 80.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB1 Gene

Disorders for CGB1 Gene

Additional Disease Information for CGB1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for CGB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CGB1 Gene

Publications for CGB1 Gene

  1. Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. (PMID: 18048458) Rull K … Laan M (Molecular human reproduction 2008) 3 4
  2. The evolution and genomic landscape of CGB1 and CGB2 genes. (PMID: 17055150) Hallast P … Laan M (Molecular and cellular endocrinology 2007) 3 23
  3. Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays. (PMID: 11368883) Giovangrandi Y … Bièche I (Cancer letters 2001) 3 23
  4. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P … Boime I (The Journal of biological chemistry 1983) 2 3
  5. β-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway. (PMID: 30582718) Wu W … Guo X (Cell cycle (Georgetown, Tex.) 2019) 3

ExternalLinks

View latest publications for CGB1 gene in Mastermind

Products for CGB1 Gene

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