Aliases for CGAS Gene

Aliases for CGAS Gene

  • Cyclic GMP-AMP Synthase 2 3 4 5
  • Mab-21 Domain-Containing Protein 1 3 4
  • Mab-21 Domain Containing 1 2 3
  • 2'3'-CGAMP Synthase 3 4
  • CGAMP Synthase 3 4
  • C6orf150 3 4
  • MB21D1 3 4
  • H-CGAS 3 4
  • CGAS 4 5
  • Chromosome 6 Open Reading Frame 150 2
  • Protein MB21D1 3
  • EC 2.7.7.86 4

External Ids for CGAS Gene

Previous HGNC Symbols for CGAS Gene

  • C6orf150
  • MB21D1

Summaries for CGAS Gene

GeneCards Summary for CGAS Gene

CGAS (Cyclic GMP-AMP Synthase) is a Protein Coding gene. Diseases associated with CGAS include Herpes Simplex and Sting-Associated Vasculopathy With Onset In Infancy. Among its related pathways are Shigellosis and Cytosolic sensors of pathogen-associated DNA. An important paralog of this gene is ITPRIPL2.

UniProtKB/Swiss-Prot Summary for CGAS Gene

  • Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990, PubMed:29976794, PubMed:30799039). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Preferentially recognizes and binds curved long DNAs (PubMed:30007416). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less cyclic GMP-AMP (cGAMP), allowing a more fine-tuned response to pathogens (PubMed:30007416). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100). cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability (PubMed:28738408, PubMed:28759889). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (PubMed:28738408, PubMed:28759889). Acts as a suppressor of DNA repair in response to DNA damage: translocates to the nucleus following dephosphorylation at Tyr-215 and inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CGAS Gene

Genomics for CGAS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CGAS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CGAS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CGAS

Genomic Locations for CGAS Gene

Genomic Locations for CGAS Gene
chr6:73,413,515-73,452,297
(GRCh38/hg38)
Size:
38,783 bases
Orientation:
Minus strand
chr6:74,123,238-74,162,043
(GRCh37/hg19)
Size:
38,806 bases
Orientation:
Minus strand

Genomic View for CGAS Gene

Genes around CGAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGAS Gene

Proteins for CGAS Gene

  • Protein details for CGAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N884-CGAS_HUMAN
    Recommended name:
    Cyclic GMP-AMP synthase
    Protein Accession:
    Q8N884
    Secondary Accessions:
    • L0L2J9
    • Q14CV6
    • Q32NC9
    • Q5SWL0
    • Q5SWL1
    • Q96E45

    Protein attributes for CGAS Gene

    Size:
    522 amino acids
    Molecular mass:
    58814 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer in the absence of DNA (PubMed:28363908). Homodimer in presence of dsDNA: forms a 2:2 dimer with two enzymes binding to two DNA molecules (PubMed:30007416, PubMed:30799039). Interacts with PQBP1 (via WW domain) (PubMed:26046437). Interacts with TRIM14; this interaction stabilizes CGAS and promotes type I interferon production (PubMed:27666593). Interacts with ZCCHC3; promoting sensing of dsDNA by CGAS (PubMed:30135424). Interacts with PARP1; interaction takes place in the nucleus and prevents the formation of the PARP1-TIMELESS complex (PubMed:30356214).
    • (Microbial infection) Interacts with herpes virus 8/HHV-8 protein ORF52; this interaction inhibits cGAS enzymatic activity.
    • (Microbial infection) Interacts with herpes simplex virus 1 protein UL37; this interaction deaminates CGAS and inhibits its activation.
    • (Microbial infection) Interacts with cytomegalovirus protein UL31; this interaction promotes dissociation of DNA from CGAS, thereby inhibiting the enzymatic activity of CGAS.
    SequenceCaution:
    • Sequence=AAH12928.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGAS Gene

    Alternative splice isoforms for CGAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGAS Gene

Post-translational modifications for CGAS Gene

  • Phosphorylation at Tyr-215 by BLK promotes cytosolic retention (PubMed:30356214). Translocates into the nucleus following dephosphorylation at Tyr-215 (PubMed:30356214).
  • (Microbial infection) Deamidated on 'Asn-210' by herpes simplex virus 1 protein UL37. This modification significantly reduces CGAS-dependent cGAMP production and innate immune signaling induced by dsDNA.
  • Polyglutamylated by TTLL6 at Glu-286, leading to impair DNA-binding activity. Monoglutamylated at Glu-314 by TTLL4, leading to impair the nucleotidyltransferase activity. Deglutamylated by AGBL5/CCP5 and AGBL6/CCP6.
  • Cleaved by CASP1 at Asp-140 and Asp-157 upon DNA virus infection; the cleavage impairs cGAMP production (PubMed:28314590). Also cleaved by the pyroptotic CASP4 and CASP5 during non-canonical inflammasome activation; they don't cut at the same sites than CASP1 (PubMed:28314590).
  • Acetylation at Lys-384, Lys-394 and Lys-414 inhibits the cyclic GMP-AMP synthase activity (PubMed:30799039). Deacetylated upon cytosolic DNA challenge such as viral infections (PubMed:30799039). Acetylation can be mediated by aspirin (acetylsalicylate) drug, which directly acetylates CGAS (PubMed:30799039). Acetylation by aspirin efficiently inhibits CGAS-mediated immune responses and is able to suppress self-DNA-induced autoimmunity (PubMed:30799039).
  • Ubiquitination at Lys347, Lys355, and Lys414
  • Modification sites at PhosphoSitePlus

Other Protein References for CGAS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGAS Gene

Domains & Families for CGAS Gene

Gene Families for CGAS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for CGAS Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CGAS Gene

GenScript: Design optimal peptide antigens:
  • Mab-21 domain-containing protein 1 (M21D1_HUMAN)
  • Chromosome 6 open reading frame 150 (Q14CV6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N884

UniProtKB/Swiss-Prot:

CGAS_HUMAN :
  • Lys-187 and Leu-195 residues are specific to human and destabilize the interactions with short DNA, shifting the specificity toward the detection of curved long DNAs (PubMed:30007416). Lys-187 and Leu-195 also restrain cGAMP production and, therefore, immune activation, allowing a more fine-tuned response to pathogens (PubMed:30007416).
  • Belongs to the mab-21 family.
Domain:
  • Lys-187 and Leu-195 residues are specific to human and destabilize the interactions with short DNA, shifting the specificity toward the detection of curved long DNAs (PubMed:30007416). Lys-187 and Leu-195 also restrain cGAMP production and, therefore, immune activation, allowing a more fine-tuned response to pathogens (PubMed:30007416).
  • The N-terminal part (1-160) binds unspecifically dsDNA and expand the binding and moving range of CGAS on dsDNA. Enhances the enzyme activity and activation of innate immune signaling upon cytosolic recognition of dsDNA (PubMed:28363908, PubMed:28214358). When the N-terminal part (1-160) is missing the protein bound to dsDNA homodimerizes (By similarity).
Family:
  • Belongs to the mab-21 family.
genes like me logo Genes that share domains with CGAS: view

Function for CGAS Gene

Molecular function for CGAS Gene

UniProtKB/Swiss-Prot Function:
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990, PubMed:29976794, PubMed:30799039). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Preferentially recognizes and binds curved long DNAs (PubMed:30007416). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less cyclic GMP-AMP (cGAMP), allowing a more fine-tuned response to pathogens (PubMed:30007416). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100). cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability (PubMed:28738408, PubMed:28759889). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (PubMed:28738408, PubMed:28759889). Acts as a suppressor of DNA repair in response to DNA damage: translocates to the nucleus following dephosphorylation at Tyr-215 and inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + GTP = 2',3'-cGAMP + 2 diphosphate; Xref=Rhea:RHEA:42064, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:143093; EC=2.7.7.86; Evidence={ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:28934246, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30799039};.
UniProtKB/Swiss-Prot Induction:
By type I interferons.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=35 uM for ATP (with 1 mM GTP) {ECO:0000269|PubMed:28934246}; KM=30 uM for GTP (with 1 mM ATP) {ECO:0000269|PubMed:28934246};
UniProtKB/Swiss-Prot EnzymeRegulation:
The enzyme activity is strongly increased by double-stranded DNA, but not by single-stranded DNA or RNA (PubMed:23258413, PubMed:23707061, PubMed:26300263). Acetylation at Lys-384, Lys-394 and Lys-414 inhibits the cyclic GMP-AMP synthase activity (PubMed:30799039). Inhibited by aspirin (acetylsalicylate) drug, which acetylates CGAS (PubMed:30799039). The enzyme activity is impaired by the cleavage at Asp-140 and Asp-157 produced by CASP1 (PubMed:28314590). Strongly inhibited by compound PF-06928215, which is specific for human protein (PubMed:28934246, PubMed:30007416).

Enzyme Numbers (IUBMB) for CGAS Gene

Phenotypes From GWAS Catalog for CGAS Gene

Gene Ontology (GO) - Molecular Function for CGAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IEA,IDA 23258413
GO:0003682 chromatin binding IEA,IDA 28738408
GO:0003690 double-stranded DNA binding IEA,IDA 24077100
GO:0005515 protein binding IPI 26046437
genes like me logo Genes that share ontologies with CGAS: view
genes like me logo Genes that share phenotypes with CGAS: view

Animal Models for CGAS Gene

MGI Knock Outs for CGAS:
  • Cgas Cgas<tm1a(EUCOMM)Hmgu>
  • Cgas Cgas<tm1d(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGAS

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CGAS Gene

Localization for CGAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGAS Gene

Cell membrane. Peripheral membrane protein. Cytoplasm, cytosol. Nucleus. Note=In resting conditions, localizes at the cell membrane as a peripheral membrane protein by binding to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (PubMed:30827685). Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685). Following detection of double-stranded DNA (dsDNA), released from the cell membrane into the cytosol in order to signal (PubMed:30827685). Upon transfection with dsDNA forms punctate structures that co-localize with DNA and Beclin-1 (BECN1) (PubMed:26048138). Phosphorylation at Tyr-215 promotes cytosolic retention; translocates into the nucleus following dephosphorylation (PubMed:30356214). {ECO:0000269 PubMed:26048138, ECO:0000269 PubMed:30356214, ECO:0000269 PubMed:30827685}.
Note=(Microbial infection) Upon infection with virulent M.tuberculosis forms aggregates with dsDNA, non-virulent bacteria (without the ESX-1 locus) do not form these aggregates (PubMed:26048138). .

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGAS gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 3
endosome 3
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Centriolar satellite (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CGAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 29937271
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA,IDA 30827685
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CGAS: view

Pathways & Interactions for CGAS Gene

genes like me logo Genes that share pathways with CGAS: view

Gene Ontology (GO) - Biological Process for CGAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response IEA,IMP 23258413
GO:0002230 positive regulation of defense response to virus by host IBA,IMP 23258413
GO:0002376 immune system process IEA --
GO:0002637 regulation of immunoglobulin production IEA --
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with CGAS: view

No data available for SIGNOR curated interactions for CGAS Gene

Drugs & Compounds for CGAS Gene

(2) Drugs for CGAS Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(2) Additional Compounds for CGAS Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cyclic GMP-AMP
  • 3',5'-Cyclic GMP-AMP
  • c[g(3',5')PA(3',5')P]
  • Cyclic GMP-AMP
  • Cyclic guanosine monophosphate-adenosine monophosphate
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with CGAS: view

Transcripts for CGAS Gene

mRNA/cDNA for CGAS Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CGAS

Alternative Splicing Database (ASD) splice patterns (SP) for CGAS Gene

No ASD Table

Relevant External Links for CGAS Gene

GeneLoc Exon Structure for
CGAS

Expression for CGAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CGAS

mRNA Expression by UniProt/SwissProt for CGAS Gene:

Q8N884-CGAS_HUMAN
Tissue specificity: Expressed in the monocytic cell line THP1.

Evidence on tissue expression from TISSUES for CGAS Gene

  • Spleen(4.6)
  • Nervous system(4.5)
  • Skin(3)
  • Blood(2.9)
  • Lymph node(2.9)
  • Bone marrow(2.4)
  • Kidney(2.4)
  • Intestine(2.3)
  • Liver(2.3)
  • Heart(2.2)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with CGAS: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGAS Gene

Orthologs for CGAS Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGAS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MB21D1 30 31
  • 98.79 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MB21D1 30 31
  • 75.15 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mb21d1 30 31
  • 73.8 (n)
OneToOne
Cgas 17
Rat
(Rattus norvegicus)
Mammalia Mb21d1 30
  • 69.63 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MB21D1 31
  • 61 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MB21D1 31
  • 60 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MB21D1 31
  • 51 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MB21D1 30 31
  • 59.81 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MB21D1 31
  • 40 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488048 30
  • 50.23 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC557043 30
  • 48.68 (n)
mb21d1 31
  • 38 (a)
OneToOne
Species where no ortholog for CGAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for CGAS Gene

ENSEMBL:
Gene Tree for CGAS (if available)
TreeFam:
Gene Tree for CGAS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CGAS: view image

Paralogs for CGAS Gene

genes like me logo Genes that share paralogs with CGAS: view

Variants for CGAS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CGAS Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
773470 Likely Benign: not provided 73,452,132(-) G/C MISSENSE_VARIANT
rs749545076 Not Provided: not provided 73,451,915(-) C/CTG FRAMESHIFT_VARIANT
rs610913 - p.Pro261His
rs9352000 - p.Thr35Asn

Additional dbSNP identifiers (rs#s) for CGAS Gene

Structural Variations from Database of Genomic Variants (DGV) for CGAS Gene

Variant ID Type Subtype PubMed ID
esv1755651 CNV deletion 17803354
esv2264885 CNV deletion 18987734
esv2461232 CNV deletion 19546169
esv2665458 CNV deletion 23128226
esv2732293 CNV deletion 23290073
esv3539974 CNV deletion 23714750
esv3609510 CNV loss 21293372
esv4605 CNV loss 18987735
esv6440 CNV loss 19470904
nsv1074410 CNV deletion 25765185
nsv1140666 CNV deletion 24896259
nsv1151530 CNV deletion 26484159
nsv830693 CNV loss 17160897
nsv957546 CNV deletion 24416366

Variation tolerance for CGAS Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CGAS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGAS Gene

Disorders for CGAS Gene

MalaCards: The human disease database

(19) MalaCards diseases for CGAS Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
sting-associated vasculopathy with onset in infancy
  • sting-associated vasculopathy, infantile-onset
cyclothymic disorder
  • affective personality disorder
separation anxiety disorder
  • separation anxiety disorder of childhood
cytomegalovirus infection
  • cytomegalovirus infections
- elite association - COSMIC cancer census association via MalaCards
Search CGAS in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with CGAS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGAS Gene

Publications for CGAS Gene

  1. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. (PMID: 23258413) Sun L … Chen ZJ (Science (New York, N.Y.) 2013) 2 3 4
  2. Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity. (PMID: 30799039) Dai J … Li T (Cell 2019) 3 4
  3. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. (PMID: 30827685) Barnett KC … Kagan JC (Cell 2019) 3 4
  4. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. (PMID: 30356214) Liu H … Ge B (Nature 2018) 3 4
  5. Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion. (PMID: 29937271) Huang ZF … Wang YY (Cell host & microbe 2018) 3 4

Products for CGAS Gene

  • Signalway Proteins for CGAS

Sources for CGAS Gene