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The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
CGA (Glycoprotein Hormones, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with CGA include Ectopic Pregnancy and Ovarian Hyperstimulation Syndrome. Among its related pathways are Integrin Pathway and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005179 | hormone activity | IEA,IMP | 11207219 |
GO:0005515 | protein binding | IPI | 11222739 |
GO:0016913 | follicle-stimulating hormone activity | IDA | 2494176 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | IBA,IDA | 2494176 |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0016914 | follicle-stimulating hormone complex | IDA | 2494176 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Metabolism of steroid hormones | ||
3 | Peptide hormone metabolism | ||
4 | Signaling by GPCR | ||
5 | Amine-derived hormones |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006357 | regulation of transcription by RNA polymerase II | TAS | -- |
GO:0006590 | thyroid hormone generation | IEA,IBA | 21873635 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0008284 | positive regulation of cell proliferation | NAS | 20613903 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
leucovorin | Approved | Pharma | 3692,1548 | |||
Cetuximab | Approved | Pharma | EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors | 869 | ||
Fluorouracil | Approved | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor | 2338 | ||
Levoleucovorin | Approved, Investigational | Pharma | 948 | |||
Folic acid | Approved, Vet_approved | Nutra | 4765 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Luteinizing hormone releasing hormone human acetate salt (LHRH) | 71447-49-9 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | CGA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | CGA 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | CGA 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Cga 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Cga 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | CGA 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | CGA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | CGA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | CGA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | cga 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | tsha-A 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | cga 30 31 |
|
OneToOne | |
Dr.13896 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11927 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1002835 | CNV | deletion | 20482838 |
esv2763585 | CNV | gain | 21179565 |
nsv5385 | CNV | deletion | 18451855 |
nsv604106 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ectopic pregnancy |
|
|
ovarian hyperstimulation syndrome |
|
|
ovarian disease |
|
|
triploidy |
|
|
ovarian remnant syndrome |
|
|