Aliases for CFP Gene
External Ids for CFP Gene
Previous HGNC Symbols for CFP Gene
Previous GeneCards Identifiers for CFP Gene
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
GeneCards Summary for CFP Gene
CFP (Complement Factor Properdin) is a Protein Coding gene. Diseases associated with CFP include Properdin Deficiency, X-Linked and Properdin Deficiency. Among its related pathways are O-glycosylation of TSR domain-containing proteins and Diseases of glycosylation.
UniProtKB/Swiss-Prot Summary for CFP Gene
A positive regulator of the alternate pathway (AP) of complement (PubMed:20382442, PubMed:28264884). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:20382442, PubMed:28264884). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604).