Aliases for CFL1 Gene
External Ids for CFL1 Gene
Previous HGNC Symbols for CFL1 Gene
Previous GeneCards Identifiers for CFL1 Gene
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
GeneCards Summary for CFL1 Gene
CFL1 (Cofilin 1) is a Protein Coding gene. Diseases associated with CFL1 include Smith-Lemli-Opitz Syndrome and Juvenile Nasopharyngeal Angiofibroma. Among its related pathways are G-protein signaling RAC1 in cellular process and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CFL2.
UniProtKB/Swiss-Prot Summary for CFL1 Gene
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).