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Aliases for CFAP77 Gene

Aliases for CFAP77 Gene

  • Cilia And Flagella Associated Protein 77 2 3 5
  • C9orf171 3 4
  • Cilia- And Flagella-Associated Protein 77 3
  • Chromosome 9 Open Reading Frame 171 2

External Ids for CFAP77 Gene

Previous HGNC Symbols for CFAP77 Gene

  • C9orf171

Previous GeneCards Identifiers for CFAP77 Gene

  • GC09P132420
  • GC09P132428
  • GC09P132431
  • GC09P132434
  • GC09P132437
  • GC09P132440
  • GC09P132445

Summaries for CFAP77 Gene

GeneCards Summary for CFAP77 Gene

CFAP77 (Cilia And Flagella Associated Protein 77) is a Protein Coding gene.

Additional gene information for CFAP77 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP77 Gene

Genomics for CFAP77 Gene

GeneHancer (GH) Regulatory Elements for CFAP77 Gene

Promoters and enhancers for CFAP77 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J132409 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 +0.2 196 1 ZSCAN4 ARID4B KLF17 SIN3A BMI1 KLF14 ZNF2 KLF5 ZNF48 ZNF335 CFAP77 LOC105376304 RPL7A EEF1A1P5 MED22 SURF4 SETX GTF3C5
GH09J132411 Enhancer 0.8 ENCODE 650.7 +1.2 1226 0.2 RB1 ARID4B KLF17 SIN3A ZNF48 RAD21 ZNF335 GLIS2 ZNF213 ARID2 CFAP77 LOC105376304
GH09J131723 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.6 -677.7 -677729 17.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 RAPGEF1 POMT1 ENSG00000176868 CFAP77 FAM78A PRRC2B NTNG2 RN7SL328P
GH09J131743 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.9 -665.1 -665088 3.5 NCOA3 CEBPG CTBP1 GATA3 RCOR1 PRDM10 SMARCE1 STAT1 PHF21A HLF RAPGEF1 CFAP77 FAM78A EIF4A1P3
GH09J132531 Enhancer 0.4 FANTOM5 12.3 +121.9 121921 0.4 ZBTB8A ZIC2 CFAP77 SPACA9 AK8 BARHL1 RNU5D-2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CFAP77 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CFAP77 Gene

Genomic Locations for CFAP77 Gene
chr9:132,410,043-132,573,319
(GRCh38/hg38)
Size:
163,277 bases
Orientation:
Plus strand
chr9:135,285,430-135,448,704
(GRCh37/hg19)

Genomic View for CFAP77 Gene

Genes around CFAP77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP77 Gene

Proteins for CFAP77 Gene

  • Protein details for CFAP77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQR2-CFA77_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 77
    Protein Accession:
    Q6ZQR2
    Secondary Accessions:
    • Q147X1

    Protein attributes for CFAP77 Gene

    Size:
    320 amino acids
    Molecular mass:
    36499 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CFAP77 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP77 Gene

Post-translational modifications for CFAP77 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP77 Gene

No data available for DME Specific Peptides for CFAP77 Gene

Domains & Families for CFAP77 Gene

Gene Families for CFAP77 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CFAP77 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6ZQR2

UniProtKB/Swiss-Prot:

CFA77_HUMAN :
  • Belongs to the CFAP77 family.
Family:
  • Belongs to the CFAP77 family.
genes like me logo Genes that share domains with CFAP77: view

No data available for Suggested Antigen Peptide Sequences for CFAP77 Gene

Function for CFAP77 Gene

Phenotypes From GWAS Catalog for CFAP77 Gene

Gene Ontology (GO) - Molecular Function for CFAP77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CFAP77: view
genes like me logo Genes that share phenotypes with CFAP77: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP77 Gene

Localization for CFAP77 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP77 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFAP77 gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CFAP77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CFAP77: view

Pathways & Interactions for CFAP77 Gene

SuperPathways for CFAP77 Gene

No Data Available

Interacting Proteins for CFAP77 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343290%0d%0a9606.ENSP00000382982%0d%0a
Selected Interacting proteins: Q6ZQR2-CFA77_HUMAN ENSP00000343290 for CFAP77 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for CFAP77 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP77 Gene

Drugs & Compounds for CFAP77 Gene

No Compound Related Data Available

Transcripts for CFAP77 Gene

mRNA/cDNA for CFAP77 Gene

(8) Selected AceView cDNA sequences:
(5) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP77 Gene

No ASD Table

Relevant External Links for CFAP77 Gene

GeneLoc Exon Structure for
CFAP77
ECgene alternative splicing isoforms for
CFAP77

Expression for CFAP77 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CFAP77 Gene

Orthologs for CFAP77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFAP77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9orf171 34
  • 100 (a)
OneToOne
C9H9orf171 33
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia C11H9orf171 33
  • 89.91 (n)
C9orf171 34
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf171 33
  • 89.24 (n)
C9orf171 34
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700101E01Rik 34 33
  • 84.97 (n)
OneToOne
Cfap77 16
rat
(Rattus norvegicus)
Mammalia RGD1564114 33
  • 83.86 (n)
oppossum
(Monodelphis domestica)
Mammalia C9orf171 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf171 34
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9ORF171 33
  • 61.95 (n)
C9orf171 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491608 33
  • 59.04 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-215c18.4 33
  • 50.21 (n)
C5H9orf171 34
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4401 34
  • 42 (a)
OneToOne
Species where no ortholog for CFAP77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP77 Gene

ENSEMBL:
Gene Tree for CFAP77 (if available)
TreeFam:
Gene Tree for CFAP77 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CFAP77: view image

Paralogs for CFAP77 Gene

No data available for Paralogs for CFAP77 Gene

Variants for CFAP77 Gene

Sequence variations from dbSNP and Humsavar for CFAP77 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs149346027 A colorectal cancer sample 132,499,482(+) C/G/T coding_sequence_variant, missense_variant
rs1000010499 -- 132,454,529(+) A/C/G intron_variant
rs1000011306 -- 132,545,932(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000046007 -- 132,414,582(+) A/G intron_variant
rs1000071376 -- 132,457,994(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CFAP77 Gene

Variant ID Type Subtype PubMed ID
dgv1383e199 CNV deletion 23128226
dgv4153n106 CNV deletion 24896259
esv1000676 CNV deletion 20482838
esv1002280 CNV deletion 20482838
esv1509495 CNV deletion 17803354
esv1524647 CNV insertion 17803354
esv2070104 CNV deletion 18987734
esv2664760 CNV deletion 23128226
esv2667814 CNV deletion 23128226
esv2739131 CNV deletion 23290073
esv2739132 CNV deletion 23290073
esv2739133 CNV deletion 23290073
esv2739134 CNV deletion 23290073
esv2739135 CNV deletion 23290073
esv2739136 CNV deletion 23290073
esv3371 CNV loss 18987735
esv3545548 CNV deletion 23714750
esv3545549 CNV deletion 23714750
esv3545550 CNV deletion 23714750
esv3545551 CNV deletion 23714750
esv3573406 CNV loss 25503493
esv3621913 CNV loss 21293372
esv3621916 CNV loss 21293372
esv5190 CNV loss 18987735
esv5887 CNV loss 19470904
nsv1040162 CNV gain 25217958
nsv1124485 CNV deletion 24896259
nsv1139374 CNV deletion 24896259
nsv1141036 CNV deletion 24896259
nsv1146630 CNV deletion 26484159
nsv415449 CNV deletion 16902084
nsv415812 CNV deletion 16902084
nsv416344 CNV deletion 16902084
nsv516741 CNV loss 19592680
nsv520491 CNV gain 19592680
nsv6741 CNV deletion 18451855
nsv6744 CNV insertion 18451855

Variation tolerance for CFAP77 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.92; 89.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CFAP77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFAP77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFAP77 Gene

Disorders for CFAP77 Gene

No disorders were found for CFAP77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP77 Gene

Publications for CFAP77 Gene

  1. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. (PMID: 25169055) Lindskog C … Micke P (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for CFAP77 Gene

Sources for CFAP77 Gene

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