Aliases for CETP Gene
External Ids for CETP Gene
Previous GeneCards Identifiers for CETP Gene
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
GeneCards Summary for CETP Gene
CETP (Cholesteryl Ester Transfer Protein) is a Protein Coding gene. Diseases associated with CETP include Hyperalphalipoproteinemia 1 and Coronary Stenosis. Among its related pathways are Lipoprotein metabolism and Statin Pathway. Gene Ontology (GO) annotations related to this gene include lipid binding and lipid transporter activity. An important paralog of this gene is LBP.
UniProtKB/Swiss-Prot Summary for CETP Gene
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).
When glucose supplies are low, the body is able to draw upon lipids as an alternative energy source. Lipids are generally stored as triglycerides and the first step in lipid metabolism is the conversion to glycerol and fatty acids which then enter the Krebs cycle.