Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregatio... See more...

Aliases for CETN2 Gene

Aliases for CETN2 Gene

  • Centrin 2 2 3 5
  • CEN2 2 3 4
  • Centrin, EF-Hand Protein, 2 2 3
  • Centrin-2 3 4
  • CALT 3 4
  • Caltractin (20kD Calcium-Binding Protein) 3
  • Caltractin Isoform 1 4
  • CETN2 5

External Ids for CETN2 Gene

Previous HGNC Symbols for CETN2 Gene

  • CALT

Previous GeneCards Identifiers for CETN2 Gene

  • GC0XM146335
  • GC0XM148653
  • GC0XM149743
  • GC0XM150613
  • GC0XM151666
  • GC0XM151746
  • GC0XM151996

Summaries for CETN2 Gene

Entrez Gene Summary for CETN2 Gene

  • Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for CETN2 Gene

CETN2 (Centrin 2) is a Protein Coding gene. Diseases associated with CETN2 include Xeroderma Pigmentosum, Complementation Group C and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Organelle biogenesis and maintenance and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and microtubule binding. An important paralog of this gene is CETN1.

UniProtKB/Swiss-Prot Summary for CETN2 Gene

  • Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.
  • Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.
  • The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
  • As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.

Gene Wiki entry for CETN2 Gene

Additional gene information for CETN2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CETN2 Gene

Genomics for CETN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CETN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ152829 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -1.3 -1344 5 BRCA1 CEBPG SP1 CREB1 PRDM10 RFX1 FOS LARP7 DDX20 ZNF143 CETN2 NSDHL ZNF185 PNMA6A HSALNG0140722
GH0XJ153598 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 4.9 -768.5 -768544 4.2 ZNF692 LARP7 ZIC2 ZSCAN4 RBFOX2 POLR2A PATZ1 ZNF501 ZNF600 ZFX ENSG00000260081 CCNQ LOC105373383 ABCD1 BCAP31 KRT18P48 CETN2 lnc-DUSP9-3 ATP2B3
GH0XJ152893 Promoter/Enhancer 1.8 EPDnew FANTOM5 ENCODE CraniofacialAtlas dbSUPER 4.4 -65.2 -65165 5.3 TEAD4 KDM1A TARDBP SP2 ESR1 CTBP1 RCOR1 GABPA ESRRA POLR2A ZNF185 CETN2 HSALNG0140722 NSDHL
GH0XJ152816 Enhancer 0.6 Ensembl 0.4 +13.5 13543 0.4 CTCF REST RAD21 FOXJ2 NFIC SMC3 ZNF654 HNF4A NFE2 GATA2 HSALNG0140720 CETN2 lnc-NSDHL-1 MAGEA6
GH0XJ152819 Enhancer 0.5 Ensembl 0.4 +11.1 11056 1 CEBPB ZNF316 FOS BHLHE40 MAFK EMSY ZNF185 HSALNG0140720 CETN2 lnc-NSDHL-1 MAGEA6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CETN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CETN2

Top Transcription factor binding sites by QIAGEN in the CETN2 gene promoter:
  • Cart-1
  • CBF(2)
  • CUTL1
  • GCNF
  • GCNF-1
  • GCNF-2
  • NF-Y
  • Nkx2-2
  • STAT3

Genomic Locations for CETN2 Gene

Genomic Locations for CETN2 Gene
chrX:152,826,994-152,830,757
(GRCh38/hg38)
Size:
3,764 bases
Orientation:
Minus strand
chrX:151,995,517-151,999,321
(GRCh37/hg19)
Size:
3,805 bases
Orientation:
Minus strand

Genomic View for CETN2 Gene

Genes around CETN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CETN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CETN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CETN2 Gene

Proteins for CETN2 Gene

  • Protein details for CETN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41208-CETN2_HUMAN
    Recommended name:
    Centrin-2
    Protein Accession:
    P41208
    Secondary Accessions:
    • B2R4T4
    • Q53XW1

    Protein attributes for CETN2 Gene

    Size:
    172 amino acids
    Molecular mass:
    19738 Da
    Quaternary structure:
    • Monomer. Homooligomer (PubMed:15356003). Interacts with SFI1 (PubMed:16956364). Interacts with CCP110 (PubMed:16760425). Component of the XPC complex composed of XPC, RAD23B and CETN2 (PubMed:11279143, PubMed:15964821, PubMed:16533048, PubMed:16627479). Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least GANP, 2 copies of ENY2, PCID2, SEM1/DSS1, and either centrin CETN2 or centrin CETN3. The TREX-2 complex also associates with ALYREF/ALY and with the nucleoporin NUP153 (PubMed:22307388, PubMed:23591820).
    Miscellaneous:
    • Binds two moles of calcium per mole of protein.

    Three dimensional structures from OCA and Proteopedia for CETN2 Gene

neXtProt entry for CETN2 Gene

Post-translational modifications for CETN2 Gene

  • Ubiquitination at Lys111
  • Modification sites at PhosphoSitePlus

Other Protein References for CETN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Protein Products

  • Signalway Proteins for CETN2

No data available for DME Specific Peptides for CETN2 Gene

Domains & Families for CETN2 Gene

Gene Families for CETN2 Gene

Protein Domains for CETN2 Gene

Suggested Antigen Peptide Sequences for CETN2 Gene

GenScript: Design optimal peptide antigens:
  • Caltractin isoform 1 (CETN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41208

UniProtKB/Swiss-Prot:

CETN2_HUMAN :
  • Belongs to the centrin family.
Family:
  • Belongs to the centrin family.
genes like me logo Genes that share domains with CETN2: view

Function for CETN2 Gene

Molecular function for CETN2 Gene

UniProtKB/Swiss-Prot Function:
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.
UniProtKB/Swiss-Prot Function:
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.
UniProtKB/Swiss-Prot Function:
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
UniProtKB/Swiss-Prot Function:
As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores.

Gene Ontology (GO) - Molecular Function for CETN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IBA,NAS 8248209
GO:0005515 protein binding IPI 16760425
GO:0008017 microtubule binding IEA --
GO:0031683 G-protein beta/gamma-subunit complex binding IEA --
GO:0032795 heterotrimeric G-protein binding IEA --
genes like me logo Genes that share ontologies with CETN2: view
genes like me logo Genes that share phenotypes with CETN2: view

Animal Models for CETN2 Gene

MGI Knock Outs for CETN2:

Animal Model Products

CRISPR Products

miRNA for CETN2 Gene

miRTarBase miRNAs that target CETN2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CETN2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CETN2 Gene

Localization for CETN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CETN2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus envelope. Nucleus, nuclear pore complex. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CETN2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CETN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005643 nuclear pore IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CETN2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CETN2 Gene

Pathways & Interactions for CETN2 Gene

genes like me logo Genes that share pathways with CETN2: view

Pathways by source for CETN2 Gene

1 Cell Signaling Technology pathway for CETN2 Gene

SIGNOR curated interactions for CETN2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CETN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle NAS 8248209
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with CETN2: view

Drugs & Compounds for CETN2 Gene

(1) Drugs for CETN2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 6556
genes like me logo Genes that share compounds with CETN2: view

Transcripts for CETN2 Gene

mRNA/cDNA for CETN2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CETN2

Alternative Splicing Database (ASD) splice patterns (SP) for CETN2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for CETN2 Gene

GeneLoc Exon Structure for
CETN2

Expression for CETN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CETN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CETN2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CETN2 Gene



Protein tissue co-expression partners for CETN2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CETN2

SOURCE GeneReport for Unigene cluster for CETN2 Gene:

Hs.82794

Evidence on tissue expression from TISSUES for CETN2 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Blood(4.4)
  • Lung(3.1)
  • Kidney(3)
  • Skin(2.6)
  • Intestine(2.4)
  • Eye(2.2)
  • Heart(2.1)
  • Muscle(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with CETN2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CETN2 Gene

Orthologs for CETN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CETN2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CETN2 30 31
  • 99.81 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia CETN2 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Cetn2 30 17 31
  • 90.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CETN2 30 31
  • 90.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Cetn2 30
  • 90.31 (n)
Dog
(Canis familiaris)
Mammalia CETN2 30 31
  • 90.12 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia CETN2 31
  • 46 (a)
OneToOne
Chicken
(Gallus gallus)
Aves CETN1 31
  • 84 (a)
ManyToMany
CETN2 30
  • 79.46 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 74 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia cetn1 30
  • 77.13 (n)
Str.6505 30
Zebrafish
(Danio rerio)
Actinopterygii cetn2 30 31
  • 81 (a)
OneToMany
LOC100006257 30
  • 70.54 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.838 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009260 30
  • 69.75 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG17493 30 31 32
  • 65.25 (n)
ManyToMany
CG31802 31
  • 56 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea B0563.7 31
  • 24 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC31 31
  • 55 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons CEN2 30
  • 67.35 (n)
Soybean
(Glycine max)
eudicotyledons Gma.1826 30
Rice
(Oryza sativa)
Liliopsida Os07g0618800 30
  • 61.57 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1446 30
Species where no ortholog for CETN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for CETN2 Gene

ENSEMBL:
Gene Tree for CETN2 (if available)
TreeFam:
Gene Tree for CETN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CETN2: view image

Paralogs for CETN2 Gene

(27) SIMAP similar genes for CETN2 Gene using alignment to 1 proteins:

  • CETN2_HUMAN

Pseudogenes.org Pseudogenes for CETN2 Gene

genes like me logo Genes that share paralogs with CETN2: view

Variants for CETN2 Gene

Additional dbSNP identifiers (rs#s) for CETN2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CETN2 Gene

Variant ID Type Subtype PubMed ID
esv25868 CNV gain 19812545
esv2758901 CNV gain 17122850
nsv470373 CNV gain 18288195

Variation tolerance for CETN2 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CETN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CETN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CETN2 Gene

Disorders for CETN2 Gene

MalaCards: The human disease database

(15) MalaCards diseases for CETN2 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search CETN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CETN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with CETN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CETN2 Gene

Publications for CETN2 Gene

  1. Binding of human centrin 2 to the centrosomal protein hSfi1. (PMID: 16956364) Martinez-Sanz J … Craescu CT (The FEBS journal 2006) 3 4 23
  2. Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair. (PMID: 16533048) Yang A … Craescu CT (Biochemistry 2006) 3 4 23
  3. The structure of the human centrin 2-xeroderma pigmentosum group C protein complex. (PMID: 16627479) Thompson JR … Kumar R (The Journal of biological chemistry 2006) 3 4 23
  4. The N-terminal domain of human centrin 2 has a closed structure, binds calcium with a very low affinity, and plays a role in the protein self-assembly. (PMID: 16411764) Yang A … Craescu CT (Biochemistry 2006) 3 4 23
  5. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. (PMID: 15964821) Nishi R … Hanaoka F (Molecular and cellular biology 2005) 3 4 23

Products for CETN2 Gene

  • Signalway Proteins for CETN2

Sources for CETN2 Gene