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Aliases for CES4A Gene

Aliases for CES4A Gene

  • Carboxylesterase 4A 2 3 3 5
  • Carboxylesterase 8 (Putative) 2 3
  • CES8 3 4
  • Carboxylesterase 6 3
  • EC 3.1.1.- 4
  • CES6 3

External Ids for CES4A Gene

Previous HGNC Symbols for CES4A Gene

  • CES8

Previous GeneCards Identifiers for CES4A Gene

  • GC16P067023

Summaries for CES4A Gene

Entrez Gene Summary for CES4A Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES4A Gene

CES4A (Carboxylesterase 4A) is a Protein Coding gene. Among its related pathways are NRF2 pathway and the visual cycle I (vertebrates). Gene Ontology (GO) annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is CES1.

UniProtKB/Swiss-Prot for CES4A Gene

  • Probable carboxylesterase.

Additional gene information for CES4A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES4A Gene

Genomics for CES4A Gene

GeneHancer (GH) Regulatory Elements for CES4A Gene

Promoters and enhancers for CES4A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J066999 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 650.4 +12.0 12048 1.5 MXI1 KLF1 ZNF687 MAX ZNF121 ATF3 POLR2A VEZF1 KLF9 ZBTB33 CES4A ENSG00000260465 PIR35653 GC16P067006 GC16P066989
GH16J066988 Promoter/Enhancer 1.2 EPDnew dbSUPER 650.7 0.0 -19 0.1 DRAP1 TFAP4 FOXA2 SAP130 MAX ERF CEBPG KMT2B ZNF205 YY1 CES4A GC16P066989 CES3
GH16J066996 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.1 +8.5 8486 1.6 ELF3 FOXA2 MLX ZSCAN4 ZSCAN9 RARA YY1 SLC30A9 ZNF614 HSF1 E2F4 SLC12A4 ATP6V0D1 CES4A DYNC1LI2 CA7 CMTM4 HSF4 PIR35653 GC16P067006
GH16J066510 Enhancer 1.4 Ensembl ENCODE dbSUPER 4.5 -476.4 -476422 3.8 PKNOX1 FOXA2 ARID4B SIN3A ETS1 YY1 TCF12 ELK1 ATF7 FOS GC16M066512 PIR55233 PIR49300 BEAN1 TK2 BEAN1-AS1 CKLF CKLF-CMTM1 CMTM2 CES4A
GH16J066871 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 2.9 -114.7 -114749 5.1 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 ZNF213 NAE1 E2F4 CTCF CES2 CA7 EDC4 CENPT PLEKHG4 ZDHHC1 ACD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CES4A on UCSC Golden Path with GeneCards custom track

Genomic Locations for CES4A Gene

Genomic Locations for CES4A Gene
21,170 bases
Plus strand
21,170 bases
Plus strand

Genomic View for CES4A Gene

Genes around CES4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES4A Gene

Proteins for CES4A Gene

  • Protein details for CES4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxylesterase 4A
    Protein Accession:
    Secondary Accessions:
    • A8KAJ6
    • B7Z349
    • B7Z3L2
    • B7Z6R3
    • Q6UX55
    • Q8N9F4

    Protein attributes for CES4A Gene

    561 amino acids
    Molecular mass:
    63529 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88868.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=BAH12248.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CES4A Gene

neXtProt entry for CES4A Gene

Post-translational modifications for CES4A Gene

  • Glycosylation at posLast=388388, Asn276, and posLast=214214
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CES4A Gene

Domains & Families for CES4A Gene

Gene Families for CES4A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CES4A Gene

Suggested Antigen Peptide Sequences for CES4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES4A: view

Function for CES4A Gene

Molecular function for CES4A Gene

UniProtKB/Swiss-Prot Function:
Probable carboxylesterase.

Enzyme Numbers (IUBMB) for CES4A Gene

Gene Ontology (GO) - Molecular Function for CES4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004771 sterol esterase activity IBA --
GO:0004806 triglyceride lipase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with CES4A: view
genes like me logo Genes that share phenotypes with CES4A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CES4A

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CES4A Gene

Localization for CES4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES4A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CES4A gene
Compartment Confidence
extracellular 4
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
plasma membrane 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CES4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CES4A: view

Pathways & Interactions for CES4A Gene

genes like me logo Genes that share pathways with CES4A: view

Pathways by source for CES4A Gene

Interacting Proteins for CES4A Gene

Gene Ontology (GO) - Biological Process for CES4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016042 lipid catabolic process IBA --
genes like me logo Genes that share ontologies with CES4A: view

No data available for SIGNOR curated interactions for CES4A Gene

Drugs & Compounds for CES4A Gene

No Compound Related Data Available

Transcripts for CES4A Gene

Unigene Clusters for CES4A Gene

Carboxylesterase 4A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CES4A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES4A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4: - -

Relevant External Links for CES4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CES4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CES4A Gene

mRNA differential expression in normal tissues according to GTEx for CES4A Gene

This gene is overexpressed in Pituitary (x4.7).

Protein differential expression in normal tissues from HIPED for CES4A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CES4A Gene

Protein tissue co-expression partners for CES4A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CES4A Gene:


SOURCE GeneReport for Unigene cluster for CES4A Gene:


Evidence on tissue expression from TISSUES for CES4A Gene

  • Nervous system(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CES4A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CES4A Gene

Orthologs for CES4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CES4A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CES4A 34 33
  • 99.35 (n)
(Bos Taurus)
Mammalia CES4A 34 33
  • 83.41 (n)
(Rattus norvegicus)
Mammalia Ces4a 33
  • 77.24 (n)
(Mus musculus)
Mammalia Ces4a 16 34 33
  • 76.46 (n)
(Ornithorhynchus anatinus)
Mammalia CES4A 34
  • 61 (a)
(Monodelphis domestica)
Mammalia CES4A 34
  • 48 (a)
(Gallus gallus)
Aves -- 34
  • 35 (a)
-- 34
  • 35 (a)
(Danio rerio)
Actinopterygii ces3 34
  • 29 (a)
ces2 34
  • 28 (a)
si:ch211-93f2.1 34
  • 10 (a)
Species where no ortholog for CES4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CES4A Gene

Gene Tree for CES4A (if available)
Gene Tree for CES4A (if available)
Evolutionary constrained regions (ECRs) for CES4A: view image

Paralogs for CES4A Gene

Paralogs for CES4A Gene

(33) SIMAP similar genes for CES4A Gene using alignment to 5 proteins:

  • F5H5S4_HUMAN
  • I3L191_HUMAN
genes like me logo Genes that share paralogs with CES4A: view

Variants for CES4A Gene

Sequence variations from dbSNP and Humsavar for CES4A Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000845454 -- 66,990,061(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000947993 -- 66,994,093(+) T/A genic_upstream_transcript_variant, intron_variant
rs1001019954 -- 66,993,970(+) G/A genic_upstream_transcript_variant, intron_variant
rs1001111840 -- 67,000,214(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001120067 -- 67,003,513(+) A/G splice_acceptor_variant

Structural Variations from Database of Genomic Variants (DGV) for CES4A Gene

Variant ID Type Subtype PubMed ID
dgv526e214 CNV gain 21293372
nsv1840 CNV insertion 18451855
nsv509626 CNV insertion 20534489
nsv827706 CNV loss 20364138

Variation tolerance for CES4A Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CES4A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES4A Gene

Disorders for CES4A Gene

Additional Disease Information for CES4A

No disorders were found for CES4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES4A Gene

Publications for CES4A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes RS … Maltais LJ (Mammalian genome : official journal of the International Mammalian Genome Society 2010) 2 3 58
  3. Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes. (PMID: 17364878) Hosokawa M … Chiba K (Drug metabolism reviews 2007) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58

Products for CES4A Gene

Sources for CES4A Gene

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