This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier syste... See more...

Aliases for CES2 Gene

Aliases for CES2 Gene

  • Carboxylesterase 2 2 3 4 5
  • Methylumbelliferyl-Acetate Deacetylase 2 3 4
  • Carboxylesterase 2 (Intestine, Liver) 2 3
  • Cocaine Esterase 3 4
  • EC 3.1.1.1 4 52
  • CE-2 3 4
  • ICE 3 4
  • Intestinal Carboxylesterase; Liver Carboxylesterase-2 3
  • EC 3.1.1.84 4
  • EC 3.1.1.56 4
  • EC 3.1.1 52
  • CES2A1 3
  • PCE-2 3
  • HCE-2 4

External Ids for CES2 Gene

Previous GeneCards Identifiers for CES2 Gene

  • GC16P057662
  • GC16P067346
  • GC16P066703
  • GC16P066744
  • GC16P065525
  • GC16P066969
  • GC16P052842

Summaries for CES2 Gene

Entrez Gene Summary for CES2 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

GeneCards Summary for CES2 Gene

CES2 (Carboxylesterase 2) is a Protein Coding gene. Diseases associated with CES2 include North American Indian Childhood Cirrhosis and Large Intestine Adenoma. Among its related pathways are Cytochrome P450 - arranged by substrate type and Fluoropyrimidine Activity. Gene Ontology (GO) annotations related to this gene include hydrolase activity and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES1.

UniProtKB/Swiss-Prot Summary for CES2 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).

Gene Wiki entry for CES2 Gene

Additional gene information for CES2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CES2 Gene

Genomics for CES2 Gene

GeneHancer (GH) Regulatory Elements for CES2 Gene

Promoters and enhancers for CES2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J066932 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 510.4 +0.9 857 5 EP300 ZBTB40 ZNF217 SIN3A NRF1 TCF12 POLR2G SP1 GTF2E2 PHF8 CES2 CIAO2B NAE1 CES3 ENSG00000265408 lnc-FAM96B-3
GH16J066871 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 24.7 -60.6 -60604 5.1 CTCF ZSCAN5C NRF1 TCF12 MYC JUND FOS ZNF639 ZNF10 EP300 NAE1 CES2 E2F4 CA7 PLEKHG4 ZDHHC1 ENSG00000260465 CIAO2B FBXL8 CTCF
GH16J066879 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 24.3 -53.6 -53643 2.8 HNRNPK ZBTB40 SIN3A TCF12 NRF1 USF1 POLR2G SP1 PHF8 FOS PDP2 lnc-PDP2-3 CES2 B3GNT9 CTCF ENSG00000260465 CDH16 RRAD NAE1 ZDHHC1
GH16J066902 Enhancer 1.8 VISTA FANTOM5 ENCODE CraniofacialAtlas dbSUPER 24.8 -29.9 -29903 4.1 FOXK2 NCOR1 FOS ZNF10 ZIC2 KDM6A TCF7 ZBTB25 MYC CTBP1 CES2 KIAA0895L E2F4 NAE1 RRAD CIAO2B EDC4 CENPT CTCF EXOC3L1
GH16J066749 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 20.2 -183.2 -183244 3.2 RXRA EP300 CTCF SIN3A NRF1 MYC POLR2G GTF2E2 PHF8 ZFX DYNC1LI2 ENSG00000246777 CES2 TERB1 CA7 CDH16 RRAD CMTM3 NAE1 ENSG00000260558
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CES2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CES2

Top Transcription factor binding sites by QIAGEN in the CES2 gene promoter:
  • AML1a

Genomic Locations for CES2 Gene

Genomic Locations for CES2 Gene
chr16:66,934,444-66,945,096
(GRCh38/hg38)
Size:
10,653 bases
Orientation:
Plus strand
chr16:66,968,347-66,978,999
(GRCh37/hg19)
Size:
10,653 bases
Orientation:
Plus strand

Genomic View for CES2 Gene

Genes around CES2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES2 Gene

Proteins for CES2 Gene

  • Protein details for CES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00748-EST2_HUMAN
    Recommended name:
    Cocaine esterase
    Protein Accession:
    O00748
    Secondary Accessions:
    • A0A024R6X1
    • A8K367
    • Q16859
    • Q5MAB8
    • Q7Z366
    • Q8IUP4
    • Q8TCP8

    Protein attributes for CES2 Gene

    Size:
    559 amino acids
    Molecular mass:
    61807 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • [Isoform 3]: Probably produced by alternative initiation of isoform 1. Does not contain a signal peptide. The biological function of the extra amino acids in the N-terminus remains to be determined.
    • [Isoform 4]: Probably produced by alternative initiation of isoform 2. Does not contain a signal peptide. The biological function of the extra amino acids in the N-terminus remains to be determined.

    Alternative splice isoforms for CES2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES2 Gene

Selected DME Specific Peptides for CES2 Gene

O00748:
  • AALRWVQ
  • AIMESGVA
  • PLGPLRF
  • GFFSTGD
  • FLGIPFA
  • YRLGVLGF
  • PVMVWIHGG

Post-translational modifications for CES2 Gene

Domains & Families for CES2 Gene

Gene Families for CES2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CES2 Gene

Suggested Antigen Peptide Sequences for CES2 Gene

GenScript: Design optimal peptide antigens:
  • Carboxylesterase 2 (EST2_HUMAN)
  • CES2 protein (Q4G0E9_HUMAN)
  • CES2 protein (Q6IPK9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00748

UniProtKB/Swiss-Prot:

EST2_HUMAN :
  • Belongs to the type-B carboxylesterase/lipase family.
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES2: view

Function for CES2 Gene

Molecular function for CES2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cocaine + H2O = benzoate + ecgonine methyl ester + H(+); Xref=Rhea:RHEA:27506, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:59908, ChEBI:CHEBI:60056; EC=3.1.1.84; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255 PROSITE-ProRule:PRU10039, ECO:0000269 PubMed:9169443};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+); Xref=Rhea:RHEA:12208, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17224, ChEBI:CHEBI:17763, ChEBI:CHEBI:30089; EC=3.1.1.56; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.39 mM for cocaine {ECO:0000269 PubMed:9169443}; KM=0.15 mM for 4-methylumbelliferyl acetate {ECO:0000269 PubMed:9169443}; KM=6.8 mM for heroin {ECO:0000269 PubMed:9169443}; KM=0.13 mM for 6-monoacetylmorphine {ECO:0000269 PubMed:9169443};

Enzyme Numbers (IUBMB) for CES2 Gene

Phenotypes From GWAS Catalog for CES2 Gene

Gene Ontology (GO) - Molecular Function for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0047374 methylumbelliferyl-acetate deacetylase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IDA,TAS 21049984
GO:0080030 methyl indole-3-acetate esterase activity IEA --
genes like me logo Genes that share ontologies with CES2: view
genes like me logo Genes that share phenotypes with CES2: view

Animal Model Products

CRISPR Products

miRNA for CES2 Gene

miRTarBase miRNAs that target CES2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CES2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CES2 Gene

Localization for CES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CES2 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
plasma membrane 3
cytosol 3
cytoskeleton 2
mitochondrion 2
nucleus 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum TAS 9144407
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with CES2: view

Pathways & Interactions for CES2 Gene

genes like me logo Genes that share pathways with CES2: view

Gene Ontology (GO) - Biological Process for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006693 prostaglandin metabolic process IDA 21049984
GO:0006805 xenobiotic metabolic process TAS --
GO:0009056 catabolic process TAS 9169443
genes like me logo Genes that share ontologies with CES2: view

No data available for SIGNOR curated interactions for CES2 Gene

Drugs & Compounds for CES2 Gene

(21) Drugs for CES2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma Enzyme, substrate Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1353
Cocaine Approved, Illicit Pharma 592
Dabigatran etexilate Approved Pharma Enzyme, substrate 0
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 0
Prasugrel Approved Pharma Enzyme, substrate ADP receptor inhibitor 0

(13) Additional Compounds for CES2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Methylumbelliferyl acetate
  • 4-Methyl-7-acetyloxy coumarin
  • 7-(Acetyloxy)-4-methyl-2-benzopyrone
  • 7-(Acetyloxy)-4-methyl-2H-1-benzopyran-2-one
  • 7-Acetoxy-4-methylchromen-2-one
  • 7-Acetoxy-4-methylcoumarin
2747-05-9
1,4'-Bipiperidine-1'-carboxylic acid
  • [1,4'-Bipiperidine]-1'-carboxylic acid
  • [1,4'-Bipiperidine]-1'-carboxylate
  • 1,4'-Bipiperidine-1'-carboxylate
1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
71-41-0
4-Amino-1-piperidinecarboxylic acid
4-methylumbelliferone
  • 4-Methyl-7-hydroxycoumarin
  • 4-MU
  • 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran
  • 7-Hydroxy-4-methyl-2-oxo-3-chromene
  • 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one
genes like me logo Genes that share compounds with CES2: view

Transcripts for CES2 Gene

mRNA/cDNA for CES2 Gene

6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CES2

Alternative Splicing Database (ASD) splice patterns (SP) for CES2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - -
SP9: -

ExUns: 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CES2 Gene

GeneLoc Exon Structure for
CES2

Expression for CES2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CES2 Gene

mRNA differential expression in normal tissues according to GTEx for CES2 Gene

This gene is overexpressed in Liver (x5.4), Colon - Transverse (x5.2), Small Intestine - Terminal Ileum (x5.1), and Esophagus - Mucosa (x4.5).

Protein differential expression in normal tissues from HIPED for CES2 Gene

This gene is overexpressed in Liver (20.9) and Stomach (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CES2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CES2

SOURCE GeneReport for Unigene cluster for CES2 Gene:

Hs.282975

mRNA Expression by UniProt/SwissProt for CES2 Gene:

O00748-EST2_HUMAN
Tissue specificity: Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.

Evidence on tissue expression from TISSUES for CES2 Gene

  • Intestine(4.9)
  • Nervous system(4.9)
  • Liver(4.7)
  • Skin(4.4)
  • Kidney(3.1)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with CES2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CES2 Gene

Orthologs for CES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CES2 31 30
  • 97.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CES2 31 30
  • 80.01 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ces2h 30
  • 78.2 (n)
mouse
(Mus musculus)
Mammalia Ces2h 17 31 30
  • 77.78 (n)
Ces2e 31
  • 71 (a)
OneToMany
Ces2d-ps 31
  • 71 (a)
OneToMany
Ces2c 31
  • 71 (a)
OneToMany
Ces2b 31
  • 71 (a)
OneToMany
Ces2g 31
  • 69 (a)
OneToMany
Ces2a 31
  • 67 (a)
OneToMany
Ces2f 31
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CES2 31 30
  • 71.89 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 50 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ces3 31
  • 43 (a)
ManyToMany
ces2 31
  • 42 (a)
ManyToMany
si:ch211-93f2.1 31
  • 15 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta alpha-Est4 32
  • 40 (a)
CG8424 32
  • 31 (a)
alpha-Est7 32
  • 30 (a)
alpha-Est10 32
  • 30 (a)
alpha-Est2 32
  • 30 (a)
Jhe 32
  • 30 (a)
alpha-Est6 32
  • 29 (a)
Est-P 32
  • 29 (a)
clt 32
  • 29 (a)
CG5397 32
  • 29 (a)
alpha-Est1 32
  • 29 (a)
CG6414 32
  • 29 (a)
alpha-Est8 32
  • 29 (a)
Est-6 32
  • 28 (a)
CG9289 32
  • 28 (a)
CG7529 32
  • 28 (a)
CG10175 32
  • 28 (a)
alpha-Est9 32
  • 28 (a)
CG3841 32
  • 28 (a)
Glt 32
  • 27 (a)
CG12869 32
  • 27 (a)
CG4382 32
  • 26 (a)
CG9287 32
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea T07H6.1a 32
  • 39 (a)
B0238.13 32
  • 36 (a)
C52A10.2 32
  • 31 (a)
F13H6.3 32
  • 31 (a)
T02B5.3 32
  • 31 (a)
R173.3 32
  • 30 (a)
Y71H2AM.13 32
  • 29 (a)
F13H6.4 32
  • 29 (a)
K07C11.4 32
  • 28 (a)
B0238.7 32
  • 28 (a)
ges-1 32
  • 27 (a)
T28C12.4b 32
  • 27 (a)
T28C12.4a 32
  • 27 (a)
ZC376.2 32
  • 26 (a)
F55D10.3 32
  • 26 (a)
T02B5.1 32
  • 25 (a)
Species where no ortholog for CES2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CES2 Gene

ENSEMBL:
Gene Tree for CES2 (if available)
TreeFam:
Gene Tree for CES2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CES2: view image

Paralogs for CES2 Gene

Paralogs for CES2 Gene

(15) SIMAP similar genes for CES2 Gene using alignment to 7 proteins:

  • EST2_HUMAN
  • H3BUN5_HUMAN
  • J3QKN7_HUMAN
  • J3QLP1_HUMAN
  • J3QSC0_HUMAN
  • Q4G0E9_HUMAN
  • Q6IPK9_HUMAN

Pseudogenes.org Pseudogenes for CES2 Gene

genes like me logo Genes that share paralogs with CES2: view

Variants for CES2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CES2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
711525 Benign: not provided 66,941,809(+) G/A SYNONYMOUS_VARIANT
726481 Likely Benign: not provided 66,935,448(+) C/G FIVE_PRIME_UTR_VARIANT
rs72547531 - p.Arg34Trp
rs8192924 - p.Arg206His

Additional dbSNP identifiers (rs#s) for CES2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CES2 Gene

Variant ID Type Subtype PubMed ID
dgv526e214 CNV gain 21293372
nsv572904 CNV loss 21841781
nsv827706 CNV loss 20364138

Variation tolerance for CES2 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CES2 Gene

Human Gene Mutation Database (HGMD)
CES2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CES2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES2 Gene

Disorders for CES2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for CES2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
north american indian childhood cirrhosis
  • naic
large intestine adenoma
  • adenoma of large intestine
alveolar echinococcosis
  • alveolococcosis
cystic echinococcosis
  • echinococcus granulosus
cataract 1, multiple types
  • ctrct1
- elite association - COSMIC cancer census association via MalaCards
Search CES2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CES2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with CES2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CES2 Gene

Publications for CES2 Gene

  1. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. (PMID: 9169443) Pindel EV … Bosron WF (The Journal of biological chemistry 1997) 2 3 4 23 54
  2. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. (PMID: 9144407) Schwer H … Schmitz G (Biochemical and biophysical research communications 1997) 2 3 4 23 54
  3. Haplotypes and a novel defective allele of CES2 found in a Japanese population. (PMID: 17640957) Kim SR … Sawada J (Drug metabolism and disposition: the biological fate of chemicals 2007) 3 23 41 54
  4. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. (PMID: 15592324) Charasson V … Robert J (Clinical pharmacology and therapeutics 2004) 3 23 41 54
  5. Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). (PMID: 15618752) Kim SR … Sawada J (Drug metabolism and pharmacokinetics 2003) 3 4 23 54

Products for CES2 Gene

  • Signalway ELISA kits for CES2
  • Signalway Proteins for CES2

Sources for CES2 Gene