This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier syste... See more...

Aliases for CES2 Gene

Aliases for CES2 Gene

  • Carboxylesterase 2 2 3 4 5
  • CE-2 2 3 4
  • ICE 2 3 4
  • Methylumbelliferyl-Acetate Deacetylase 2 3 4
  • Carboxylesterase 2 (Intestine, Liver) 2 3
  • Cocaine Esterase 3 4
  • EC 3.1.1.1 4 50
  • CES2A1 2 3
  • Intestinal Carboxylesterase; Liver Carboxylesterase-2 3
  • EC 3.1.1.84 4
  • EC 3.1.1.56 4
  • EC 3.1.1 50
  • PCE-2 3
  • HCE-2 4
  • CES2 5

External Ids for CES2 Gene

Previous GeneCards Identifiers for CES2 Gene

  • GC16P057662
  • GC16P067346
  • GC16P066703
  • GC16P066744
  • GC16P065525
  • GC16P066969
  • GC16P052842

Summaries for CES2 Gene

Entrez Gene Summary for CES2 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

GeneCards Summary for CES2 Gene

CES2 (Carboxylesterase 2) is a Protein Coding gene. Diseases associated with CES2 include Large Intestine Adenoma and Alveolar Echinococcosis. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Phase I biotransformations, non P450. Gene Ontology (GO) annotations related to this gene include hydrolase activity and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES1.

UniProtKB/Swiss-Prot Summary for CES2 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).

Gene Wiki entry for CES2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CES2 Gene

Genomics for CES2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for CES2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CES2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CES2

Top Transcription factor binding sites by QIAGEN in the CES2 gene promoter:
  • AML1a

Genomic Locations for CES2 Gene

Latest Assembly
chr16:66,934,444-66,945,096
(GRCh38/hg38)
Size:
10,653 bases
Orientation:
Plus strand

Previous Assembly
chr16:66,968,374-66,978,999
(GRCh37/hg19 by Entrez Gene)
Size:
10,626 bases
Orientation:
Plus strand

chr16:66,968,347-66,978,999
(GRCh37/hg19 by Ensembl)
Size:
10,653 bases
Orientation:
Plus strand

Genomic View for CES2 Gene

Genes around CES2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES2 Gene

Proteins for CES2 Gene

  • Protein details for CES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00748-EST2_HUMAN
    Recommended name:
    Cocaine esterase
    Protein Accession:
    O00748
    Secondary Accessions:
    • A0A024R6X1
    • A8K367
    • Q16859
    • Q5MAB8
    • Q7Z366
    • Q8IUP4
    • Q8TCP8

    Protein attributes for CES2 Gene

    Size:
    559 amino acids
    Molecular mass:
    61807 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • [Isoform 3]: Probably produced by alternative initiation of isoform 1. Does not contain a signal peptide. The biological function of the extra amino acids in the N-terminus remains to be determined.
    • [Isoform 4]: Probably produced by alternative initiation of isoform 2. Does not contain a signal peptide. The biological function of the extra amino acids in the N-terminus remains to be determined.

    Alternative splice isoforms for CES2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES2 Gene

Selected DME Specific Peptides for CES2 Gene

O00748:
  • AALRWVQ
  • AIMESGVA
  • PLGPLRF
  • GFFSTGD
  • FLGIPFA
  • YRLGVLGF
  • PVMVWIHGG

Post-translational modifications for CES2 Gene

Domains & Families for CES2 Gene

Gene Families for CES2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CES2 Gene

Suggested Antigen Peptide Sequences for CES2 Gene

GenScript: Design optimal peptide antigens:
  • Carboxylesterase 2 (EST2_HUMAN)
  • CES2 protein (Q4G0E9_HUMAN)
  • CES2 protein (Q6IPK9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00748

UniProtKB/Swiss-Prot:

EST2_HUMAN :
  • Belongs to the type-B carboxylesterase/lipase family.
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES2: view

Function for CES2 Gene

Molecular function for CES2 Gene

UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cocaine + H2O = benzoate + ecgonine methyl ester + H(+); Xref=Rhea:RHEA:27506, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16150, ChEBI:CHEBI:59908, ChEBI:CHEBI:60056; EC=3.1.1.84; Evidence={ECO:0000269|PubMed:9169443};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:9169443};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+); Xref=Rhea:RHEA:12208, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17224, ChEBI:CHEBI:17763, ChEBI:CHEBI:30089; EC=3.1.1.56; Evidence={ECO:0000269|PubMed:9169443};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence={ECO:0000269|PubMed:21049984};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2; Xref=Rhea:RHEA:48296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:90230, ChEBI:CHEBI:606564; Evidence={ECO:0000269|PubMed:21049984};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha; Xref=Rhea:RHEA:48300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57404, ChEBI:CHEBI:90233; Evidence={ECO:0000269|PubMed:21049984};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.39 mM for cocaine {ECO:0000269|PubMed:9169443}; KM=0.15 mM for 4-methylumbelliferyl acetate {ECO:0000269|PubMed:9169443}; KM=6.8 mM for heroin {ECO:0000269|PubMed:9169443}; KM=46 uM for 2-arachidonoylglycerol {ECO:0000269|PubMed:21049984}; KM=750 uM for prostaglandin E2 1-glyceryl ester {ECO:0000269|PubMed:21049984}; KM=35 uM for prostaglandin F2alpha 1-glyceryl ester {ECO:0000269|PubMed:21049984}; KM=0.13 mM for 6-monoacetylmorphine {ECO:0000269|PubMed:9169443}; Note=kcat is 43 min(-1), 49 min(-1), 150 min(-1) with 2-arachidonoylglycerol, prostaglandin F2alpha 1-glyceryl ester and prostaglandin E2 1-glyceryl ester as substrates, respectively. {ECO:0000269|PubMed:21049984};

Enzyme Numbers (IUBMB) for CES2 Gene

Phenotypes From GWAS Catalog for CES2 Gene

Gene Ontology (GO) - Molecular Function for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004771 sterol esterase activity IBA 21873635
GO:0004806 triglyceride lipase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0047374 methylumbelliferyl-acetate deacetylase activity IEA --
GO:0052689 carboxylic ester hydrolase activity TAS,IDA 21049984
genes like me logo Genes that share ontologies with CES2: view
genes like me logo Genes that share phenotypes with CES2: view

miRNA for CES2 Gene

miRTarBase miRNAs that target CES2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CES2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CES2 Gene

Localization for CES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CES2 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
plasma membrane 3
cytosol 3
nucleus 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA 21873635
GO:0005783 endoplasmic reticulum TAS 9144407
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with CES2: view

Pathways & Interactions for CES2 Gene

genes like me logo Genes that share pathways with CES2: view

Gene Ontology (GO) - Biological Process for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006693 prostaglandin metabolic process IDA 21049984
GO:0006805 xenobiotic metabolic process TAS --
GO:0009056 catabolic process TAS 9169443
GO:0016042 lipid catabolic process IBA 21873635
genes like me logo Genes that share ontologies with CES2: view

No data available for SIGNOR curated interactions for CES2 Gene

Drugs & Compounds for CES2 Gene

(22) Drugs for CES2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma Enzyme, substrate Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1504
Cocaine Approved, Illicit Pharma 616
Dabigatran etexilate Approved Pharma Enzyme, substrate 0
Filgotinib Approved, Investigational Pharma Enzyme, metabolizer 0
Mycophenolate mofetil Approved, Investigational Pharma Enzyme, substrate IMPDH inhibitor 0

(13) Additional Compounds for CES2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Methylumbelliferyl acetate
  • 4-Methyl-7-acetyloxy coumarin
  • 7-(Acetyloxy)-4-methyl-2-benzopyrone
  • 7-(Acetyloxy)-4-methyl-2H-1-benzopyran-2-one
  • 7-Acetoxy-4-methylchromen-2-one
  • 7-Acetoxy-4-methylcoumarin
2747-05-9
1,4'-Bipiperidine-1'-carboxylic acid
  • [1,4'-Bipiperidine]-1'-carboxylic acid
  • [1,4'-Bipiperidine]-1'-carboxylate
  • 1,4'-Bipiperidine-1'-carboxylate
1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Amyl alcohol, normal
  • Amylalkohol
71-41-0
4-Amino-1-piperidinecarboxylic acid
  • 4-Amino-1-piperidinecarboxylate
4-methylumbelliferone
  • 4-Methyl-7-hydroxycoumarin
  • 4-MU
  • 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran
  • 7-Hydroxy-4-methyl-2-oxo-3-chromene
  • 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one
genes like me logo Genes that share compounds with CES2: view

Transcripts for CES2 Gene

mRNA/cDNA for CES2 Gene

6 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CES2

Alternative Splicing Database (ASD) splice patterns (SP) for CES2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - -
SP9: -

ExUns: 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CES2 Gene

GeneLoc Exon Structure for
CES2

Expression for CES2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CES2 Gene

mRNA differential expression in normal tissues according to GTEx for CES2 Gene

This gene is overexpressed in Liver (x5.4), Colon - Transverse (x5.2), Small Intestine - Terminal Ileum (x5.1), and Esophagus - Mucosa (x4.5).

Protein differential expression in normal tissues from HIPED for CES2 Gene

This gene is overexpressed in Liver (20.9) and Stomach (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CES2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CES2

SOURCE GeneReport for Unigene cluster for CES2 Gene:

Hs.282975

mRNA Expression by UniProt/SwissProt for CES2 Gene:

O00748-EST2_HUMAN
Tissue specificity: Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.

Evidence on tissue expression from TISSUES for CES2 Gene

  • Nervous system(4.9)
  • Intestine(4.9)
  • Liver(4.7)
  • Skin(4.5)
  • Kidney(3.3)
  • Muscle(2.4)
  • Stomach(2.3)
  • Lung(2.3)
  • Heart(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with CES2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CES2 Gene

Orthologs for CES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia CES2 29 30
  • 97.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia CES2 29 30
  • 80.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ces2h 29
  • 78.2 (n)
Mouse
(Mus musculus)
Mammalia Ces2h 29 16 30
  • 77.78 (n)
OneToMany
Ces2e 30
  • 71 (a)
OneToMany
Ces2d-ps 30
  • 71 (a)
OneToMany
Ces2c 30
  • 71 (a)
OneToMany
Ces2b 30
  • 71 (a)
OneToMany
Ces2g 30
  • 69 (a)
OneToMany
Ces2a 30
  • 67 (a)
OneToMany
Ces2f 30
  • 64 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia CES2 29 30
  • 71.89 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 58 (a)
OneToMany
-- 30
  • 58 (a)
OneToMany
-- 30
  • 52 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 50 (a)
ManyToMany
-- 30
  • 49 (a)
ManyToMany
-- 30
  • 48 (a)
ManyToMany
-- 30
  • 48 (a)
ManyToMany
-- 30
  • 42 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ces3 30
  • 43 (a)
ManyToMany
ces2 30
  • 42 (a)
ManyToMany
si:ch211-93f2.1 30
  • 15 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta alpha-Est4 31
  • 40 (a)
CG8424 31
  • 31 (a)
alpha-Est10 31
  • 30 (a)
alpha-Est2 31
  • 30 (a)
alpha-Est7 31
  • 30 (a)
Jhe 31
  • 30 (a)
CG5397 31
  • 29 (a)
CG6414 31
  • 29 (a)
clt 31
  • 29 (a)
Est-P 31
  • 29 (a)
alpha-Est1 31
  • 29 (a)
alpha-Est6 31
  • 29 (a)
alpha-Est8 31
  • 29 (a)
CG10175 31
  • 28 (a)
CG3841 31
  • 28 (a)
CG7529 31
  • 28 (a)
Est-6 31
  • 28 (a)
alpha-Est9 31
  • 28 (a)
CG9289 31
  • 28 (a)
Glt 31
  • 27 (a)
CG12869 31
  • 27 (a)
CG4382 31
  • 26 (a)
CG9287 31
  • 26 (a)
Worm
(Caenorhabditis elegans)
Secernentea T07H6.1a 31
  • 39 (a)
B0238.13 31
  • 36 (a)
F13H6.3 31
  • 31 (a)
T02B5.3 31
  • 31 (a)
C52A10.2 31
  • 31 (a)
R173.3 31
  • 30 (a)
Y71H2AM.13 31
  • 29 (a)
F13H6.4 31
  • 29 (a)
B0238.7 31
  • 28 (a)
K07C11.4 31
  • 28 (a)
T28C12.4a 31
  • 27 (a)
T28C12.4b 31
  • 27 (a)
ges-1 31
  • 27 (a)
F55D10.3 31
  • 26 (a)
ZC376.2 31
  • 26 (a)
T02B5.1 31
  • 25 (a)
Species where no ortholog for CES2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for CES2 Gene

ENSEMBL:
Gene Tree for CES2 (if available)
TreeFam:
Gene Tree for CES2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CES2: view image
Alliance of Genome Resources:
Additional Orthologs for CES2

Paralogs for CES2 Gene

Paralogs for CES2 Gene

(15) SIMAP similar genes for CES2 Gene using alignment to 7 proteins:

  • EST2_HUMAN
  • H3BUN5_HUMAN
  • J3QKN7_HUMAN
  • J3QLP1_HUMAN
  • J3QSC0_HUMAN
  • Q4G0E9_HUMAN
  • Q6IPK9_HUMAN

Pseudogenes.org Pseudogenes for CES2 Gene

genes like me logo Genes that share paralogs with CES2: view

Variants for CES2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CES2 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs140590822 Benign: not provided 66,941,809(+) G/A
NM_001365405.1(CES2):c.1098G>A (p.Glu366=)
SYNONYMOUS
rs546092904 Likely Benign: not provided 66,935,448(+) C/G
NM_003869.6(CES2):c.-188C>G
FIVE_PRIME_UTR
rs72547531 -- p.Arg34Trp
rs8192924 -- p.Arg206His

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for CES2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for CES2 Gene

Variant ID Type Subtype PubMed ID
dgv526e214 CNV gain 21293372
nsv572904 CNV loss 21841781
nsv827706 CNV loss 20364138

Variation tolerance for CES2 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CES2 Gene

Human Gene Mutation Database (HGMD)
CES2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CES2
Leiden Open Variation Database (LOVD)
CES2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES2 Gene

Disorders for CES2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CES2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
large intestine adenoma
  • adenoma of large intestine
alveolar echinococcosis
  • alveolococcosis
cystic echinococcosis
  • echinococcus granulosus
taeniasis
  • beef tapeworm infection
polycystic echinococcosis
  • human polycystic hydatid disease
- elite association - COSMIC cancer census association via MalaCards
Search CES2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for CES2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with CES2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CES2 Gene

Publications for CES2 Gene

  1. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. (PMID: 9169443) Pindel EV … Bosron WF (The Journal of biological chemistry 1997) 2 3 4 22
  2. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. (PMID: 9144407) Schwer H … Schmitz G (Biochemical and biophysical research communications 1997) 2 3 4 22
  3. Haplotypes and a novel defective allele of CES2 found in a Japanese population. (PMID: 17640957) Kim SR … Sawada J (Drug metabolism and disposition: the biological fate of chemicals 2007) 3 22 40
  4. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. (PMID: 15592324) Charasson V … Robert J (Clinical pharmacology and therapeutics 2004) 3 22 40
  5. Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). (PMID: 15618752) Kim SR … Sawada J (Drug metabolism and pharmacokinetics 2003) 3 4 22

Products for CES2 Gene

  • Boster Bio Antibodies for CES2
  • Boster Bio ELISA Kits for CES2

Sources for CES2 Gene