Aliases for CES2 Gene
External Ids for CES2 Gene
Previous GeneCards Identifiers for CES2 Gene
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
GeneCards Summary for CES2 Gene
CES2 (Carboxylesterase 2) is a Protein Coding gene. Diseases associated with CES2 include Large Intestine Adenoma and Alveolar Echinococcosis. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and Phase I biotransformations, non P450. Gene Ontology (GO) annotations related to this gene include hydrolase activity and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES1.
UniProtKB/Swiss-Prot Summary for CES2 Gene
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443). Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105). Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).