Aliases for CES2 Gene
External Ids for CES2 Gene
Previous GeneCards Identifiers for CES2 Gene
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
GeneCards Summary for CES2 Gene
CES2 (Carboxylesterase 2) is a Protein Coding gene. Diseases associated with CES2 include Fiedler's Myocarditis and Sparganosis. Among its related pathways are Irinotecan Pathway and Phase I biotransformations, non P450. Gene Ontology (GO) annotations related to this gene include hydrolase activity and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES3.
UniProtKB/Swiss-Prot for CES2 Gene
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.