This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier syste... See more...

Aliases for CES1P1 Gene

Aliases for CES1P1 Gene

  • Carboxylesterase 1 Pseudogene 1 2 3 5
  • Carboxylesterase 4, Pseudogene 2 3
  • PCE-3 3 4
  • CES4 3 4
  • Inactive Carboxylesterase 1 Pseudogene 1 4
  • Putative Inactive Carboxylesterase 4 4
  • Carboxylesterase-Related Protein 3
  • Placental Carboxylesterase 3 4
  • Carboxylesterase 4-Like 2
  • CES1A2 3
  • CES1A3 3
  • CESR 3

External Ids for CES1P1 Gene

Previous HGNC Symbols for CES1P1 Gene

  • CES4

Summaries for CES1P1 Gene

Entrez Gene Summary for CES1P1 Gene

  • This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene does not encode a protein and the sequence is similar to the CES1 gene, so represents a pseudogene of the CES1 gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES1P1 Gene

CES1P1 (Carboxylesterase 1 Pseudogene 1) is a Pseudogene.

UniProtKB/Swiss-Prot Summary for CES1P1 Gene

Additional gene information for CES1P1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CES1P1 Gene

Genomics for CES1P1 Gene

GeneHancer (GH) Regulatory Elements for CES1P1 Gene

Promoters and enhancers for CES1P1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J055760 Promoter 0.9 Ensembl 539.5 +0.1 134 0.6 POLR2G TCF7 CEBPB SAP130 GABPB1 DRAP1 POLR2A ZNF511 ZGPAT RXRA CES1P1 lnc-SLC6A2-2 CES1 CES1P2 piR-39858-252
GH16J055761 Enhancer 0.2 Ensembl 533.3 +1.0 1035 0.8 CES1P1 lnc-SLC6A2-2 CES1 piR-39858-252
GH16J055752 Enhancer 0.8 ENCODE 31.5 -7.1 -7050 2.7 FOXA1 SKI NFRKB ZBTB26 TBX3 TAF9B NCOR1 ZNF282 FOXA2 ZNF316 CES1P1 CES1 lnc-SLC6A2-2 CES1P2
GH16J055832 Promoter/Enhancer 1.2 EPDnew ENCODE 13 +72.5 72532 1.3 POLR2G NCOR1 KDM6A TCF7 ZBTB25 TGIF2 SKI REST ZBTB26 TBX3 CES1 CES1P1 CES1P2 piR-39858-253
GH16J055773 Enhancer 0.7 Ensembl ENCODE 14.1 +13.7 13737 1.2 NFIC FOS ZNF189 NRF1 NFIB TAF1 POLR2A ZNF660 NR3C1 ZNF24 CES1P1 piR-39858-252
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CES1P1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CES1P1 Gene

Genomic Locations for CES1P1 Gene
33,395 bases
Plus strand
33,611 bases
Plus strand

Genomic View for CES1P1 Gene

Genes around CES1P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES1P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES1P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES1P1 Gene

Proteins for CES1P1 Gene

  • Protein details for CES1P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative inactive carboxylesterase 4
    Protein Accession:
    Secondary Accessions:
    • A2RRL8
    • B9ZVS2

    Protein attributes for CES1P1 Gene

    287 amino acids
    Molecular mass:
    30679 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF14185.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for CES1P1 Gene


neXtProt entry for CES1P1 Gene

Post-translational modifications for CES1P1 Gene

  • Glycosylation at Asn80

No data available for DME Specific Peptides for CES1P1 Gene

Domains & Families for CES1P1 Gene

Protein Domains for CES1P1 Gene

Suggested Antigen Peptide Sequences for CES1P1 Gene

GenScript: Design optimal peptide antigens:
  • Placental carboxylesterase 3 (CES1P_HUMAN)
  • Carboxylesterase 1A2 (Q5TKQ9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES1P1: view

No data available for Gene Families for CES1P1 Gene

Function for CES1P1 Gene

Molecular function for CES1P1 Gene

UniProtKB/Swiss-Prot Function:
Has no esterase activity.

Phenotypes From GWAS Catalog for CES1P1 Gene

genes like me logo Genes that share phenotypes with CES1P1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CES1P1 Gene

Localization for CES1P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES1P1 Gene


No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CES1P1 Gene

Pathways & Interactions for CES1P1 Gene

PathCards logo

SuperPathways for CES1P1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CES1P1 Gene


No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for CES1P1 Gene

Drugs & Compounds for CES1P1 Gene

(3) Drugs for CES1P1 Gene - From: DrugBank and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1594
Clopidogrel Approved Pharma P2Y12 receptor antagonist 909
1,1,1-TRIFLUORO-3-(OCTYLTHIO)ACETONE Experimental Pharma Target 0
genes like me logo Genes that share compounds with CES1P1: view

Transcripts for CES1P1 Gene

mRNA/cDNA for CES1P1 Gene

2 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES1P1 Gene

No ASD Table

Relevant External Links for CES1P1 Gene

GeneLoc Exon Structure for

Expression for CES1P1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CES1P1 Gene

mRNA differential expression in normal tissues according to GTEx for CES1P1 Gene

This gene is overexpressed in Liver (x25.4).

Protein differential expression in normal tissues from HIPED for CES1P1 Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CES1P1 Gene

Protein tissue co-expression partners for CES1P1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CES1P1

SOURCE GeneReport for Unigene cluster for CES1P1 Gene:


mRNA Expression by UniProt/SwissProt for CES1P1 Gene:

Tissue specificity: Expressed in placenta.
genes like me logo Genes that share expression patterns with CES1P1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CES1P1 Gene

Orthologs for CES1P1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CES1P1 Gene

Organism Taxonomy Gene Similarity Type Details
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.159 30
(Danio rerio)
Actinopterygii wufb66e04 30
Species where no ortholog for CES1P1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CES1P1 Gene

Gene Tree for CES1P1 (if available)
Gene Tree for CES1P1 (if available)

Paralogs for CES1P1 Gene

(14) SIMAP similar genes for CES1P1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CES1P1: view

No data available for Paralogs for CES1P1 Gene

Variants for CES1P1 Gene

Structural Variations from Database of Genomic Variants (DGV) for CES1P1 Gene

Variant ID Type Subtype PubMed ID
dgv122n111 CNV deletion 26073780
dgv15e197 OTHER inversion 19546169
dgv24e213 CNV gain 24956385
dgv2985n100 CNV loss 25217958
dgv2986n100 CNV gain+loss 25217958
dgv477n67 CNV loss 20364138
dgv496e199 CNV deletion 23128226
dgv5126n54 CNV loss 21841781
dgv5127n54 CNV loss 21841781
dgv5128n54 CNV gain+loss 21841781
dgv5129n54 CNV loss 21841781
dgv5130n54 CNV loss 21841781
dgv5131n54 CNV loss 21841781
dgv5132n54 CNV loss 21841781
dgv52e203 CNV gain+loss 21179565
dgv62e19 OTHER inversion 19470904
dgv831e212 CNV loss 25503493
dgv832e212 CNV loss 25503493
dgv833e212 CNV gain 25503493
dgv834e212 CNV gain 25503493
dgv835e212 CNV loss 25503493
dgv836e212 CNV gain 25503493
dgv837e212 CNV gain 25503493
dgv838e212 CNV loss 25503493
dgv839e212 CNV loss 25503493
esv1000115 CNV loss 20482838
esv1010290 OTHER inversion 20482838
esv21956 CNV loss 19812545
esv2421900 CNV deletion 20811451
esv2714505 CNV deletion 23290073
esv2758649 CNV gain 17122850
esv2936012 CNV deletion 24192839
esv32885 CNV gain+loss 17666407
esv3571298 CNV gain 25503493
esv3571320 CNV gain 25503493
esv3582227 CNV loss 25503493
esv3584713 CNV loss 24956385
esv3638685 CNV loss 21293372
esv3638686 CNV loss 21293372
esv3638687 CNV gain 21293372
esv9707 OTHER inversion 19470904
esv998750 OTHER inversion 20482838
nsv1056715 CNV loss 25217958
nsv1061214 CNV gain 25217958
nsv1061487 CNV gain 25217958
nsv1065976 CNV gain+loss 25217958
nsv1069947 CNV deletion 25765185
nsv1118354 CNV deletion 24896259
nsv147 OTHER inversion 15895083
nsv442723 CNV loss 18776908
nsv499134 OTHER inversion 21111241
nsv511560 CNV gain 21212237
nsv572632 CNV gain 21841781
nsv572635 CNV loss 21841781
nsv572636 CNV gain+loss 21841781
nsv7284 OTHER inversion 18451855
nsv819089 CNV loss 19587683
nsv827667 CNV loss 20364138
nsv9445 CNV loss 18304495
nsv977980 CNV duplication 23825009

Additional Variant Information for CES1P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) and Variation tolerance for CES1P1 Gene

Disorders for CES1P1 Gene

Additional Disease Information for CES1P1

No disorders were found for CES1P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES1P1 Gene

Publications for CES1P1 Gene

  1. Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. (PMID: 10452915) Yan B … Yang D (Placenta 1999) 2 3 4 23 54
  2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes RS … Maltais LJ (Mammalian genome : official journal of the International Mammalian Genome Society 2010) 2 3 54
  3. Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus. (PMID: 26871237) Sanford JC … Sadee W (Pharmacogenetics and genomics 2016) 3 54
  4. The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease. (PMID: 24535487) Xie C … Miao L (Pharmacogenetics and genomics 2014) 3 54
  5. Mutation-sensitive molecular switch method to detect CES1A2 mutation in the Chinese Han and Yao populations. (PMID: 21510813) Ding XL … Miao LY (Genetic testing and molecular biomarkers 2011) 3 54

Products for CES1P1 Gene

Sources for CES1P1 Gene